Results
Title

Sugar Containing Compounds and Biological Activities of Lagochilus setulosus.

Authors

Akramov, Davlat Kh.; Mamadalieva, Nilufar Z.; Porzel, Andrea; Hussain, Hidayat; Dube, Mthandazo; Akhmedov, Akbar; Altyar, Ahmed E.; Ashour, Mohamed L.; Wessjohann, Ludger A.; Morana, Alessandra; Squillaci, Giuseppe

Abstract

Phytochemical investigation of the methanolic extract obtained from the aerial parts of Lagochilus setulosus (Lamiaceae) afforded the new compound 1-methoxy-3-O-β-glucopyranosyl-α-l-oliose (1) together with five known glycosides, namely sitosterol-3-O-β-glucoside (2), stigmasterol-3-O-β-glucoside (3), pinitol (4), 6β-hydroxyl-7-epi-loganin (5), and chlorotuberoside (6). The structures of these compounds were elucidated by extensive spectroscopic analyses, especially HR-MS, 1D and 2D NMR spectroscopy. The in vitro cytotoxic activity of the methanolic extract and the isolated compounds was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and crystal violet (CV) staining assays. In addition, the antifungal activities of the components were evaluated against Botrytis cinerea, Septoria tritici, and Phytophthora infestans. The anthelmintic potential was determined against Caenorhabditis elegans nematodes. Neither the extract nor the isolated compounds showed promising activity in all the bioassays.

Subjects

GLYCOSIDES; GENTIAN violet; CAENORHABDITIS elegans; NUCLEAR magnetic resonance spectroscopy; PHYTOPHTHORA infestans; BOTRYTIS cinerea; SUGAR

Publication

Molecules, 2021, Vol 26, Issue 6, p1755

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules26061755