Terpene Derivatives as a Potential Agent against Antimicrobial Resistance (AMR) Pathogens.

Mahizan, Nik Amirah; Yang, Shun-Kai; Moo, Chew-Li; Song, Adelene Ai-Lian; Chong, Chou-Min; Chong, Chun-Wie; Abushelaibi, Aisha; Lim, Swee-Hua Erin; Lai, Kok-Song; Avato, Pinarosa

The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed.

METABOLITES; ESSENTIAL oils; TERPENES; PATHOGENIC bacteria; ANTI-infective agents; PATHOGENIC microorganisms

Molecules, 2019, Vol 24, Issue 14, p2631

1420-3049

Academic Journal

10.3390/molecules24142631