Results
Title

Ionic Liquid-Based Ultrasonic-Assisted Extraction to Analyze Seven Compounds in Psoralea Fructus Coupled with HPLC.

Authors

Shi, Mengjun; Zhang, Juanjuan; Liu, Cunyu; Cui, Yiping; Li, Changqin; Liu, Zhenhua; Kang, Wenyi

Abstract

Psoralea Fructus is widely used in traditional Chinese medicine (TCM), and the content of psoralen, isopsoralen, neobavaisoflavone, bavachin, psoralidin, isobavachalcone, and bavachinin A is the main quality control index of Psoralea Fructus because of its clinical effects. Thus, a fast and environmentally-benign extraction method of seven compounds in Psoralea Fructus is necessary. In this work, an ionic liquid-based ultrasonic-assisted method (ILUAE) for the extraction of seven compounds from Psoralea Fructus was proposed. Several ILs of different types and parameters, including the concentration of ILs, concentration of ethanol (EtOH), solid–liquid ratio, particle size, ultrasonic time, centrifugal speed, and ultrasonic power, were optimized by the Placket–Burman (PB) design and Box–Behnken response surface analysis. Under this optimal condition, the total extraction yield of the seven compounds in Psoralea Fructus was 18.90 mg/g, and significantly greater than the conventional 75% EtOH solvent extraction.

Subjects

IONIC liquids; PSORALEA; HIGH performance liquid chromatography; NANOPARTICLES; CRYSTAL structure

Publication

Molecules, 2019, Vol 24, Issue 9, p1699

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules24091699