Title: Gypmacrophin A, a Rare Pentacyclic Sesterterpenoid, Together with Three Depsides, Functioned as New Chemical Evidence for Gypsoplaca macrophylla (Zahlbr.) Timdal Identification.
Authors: Yuan-Fei Zhou; Hai-Xia Shi; Kun Hu; Jian-Wei Tang; Xing-Ren Li; Xue Du; Han-Dong Sun; Li-Song Wang; Jian-Xin Pu
Abstract: The phytochemical investigation on 1 g of materials from Gypsoplaca macrophylla (Zahlbr.) Timdal resulted in the discovery of gypmacrophin A, a rare pentacyclic sesterterpenoid; brialmontin III, a new polysubstituted depside and two known ones, brialmontins I and II. The structure and absolute configurations of gypmacrophin A were elucidated by spectroscopic analyses and computational methods. Gypmacrophin A showed weak inhibition of AchE with an IC50 value of 32.03 µM. The four compounds provided new chemical evidence for G. macrophylla identification.
Subjects: PHYTOCHEMICALS; DEPSIDES; ESTERS; ORGANIC compounds; COMMON witch hazel
Publication: Molecules, 2017, Vol 22, Issue 10, p1675
ISSN: 1420-3049
Publication type: Academic Journal
DOI: 10.3390/molecules22101675

Gypmacrophin A, a Rare Pentacyclic Sesterterpenoid, Together with Three Depsides, Functioned as New Chemical Evidence for Gypsoplaca macrophylla (Zahlbr.) Timdal Identification.

Yuan-Fei Zhou; Hai-Xia Shi; Kun Hu; Jian-Wei Tang; Xing-Ren Li; Xue Du; Han-Dong Sun; Li-Song Wang; Jian-Xin Pu