We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Oleuropein and Cancer Chemoprevention: The Link is Hot.
- Authors
Farooqi, Ammad Ahmad; Fayyaz, Sundas; Sanches Silva, Ana; Sureda, Antoni; Nabavi, Seyed Fazel; Mocan, Andrei; Nabavi, Seyed Mohammad; Bishayee, Anupam
- Abstract
Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed.
- Subjects
CHEMOPREVENTION; PHENOLS; ANTICARCINOGENIC agents; ANTINEOPLASTIC agents; CANCER treatment
- Publication
Molecules, 2017, Vol 22, Issue 5, p705
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules22050705