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- Title
Nitric Oxide Donors and Selective Carbonic Anhydrase Inhibitors: A Dual Pharmacological Approach for the Treatment of Glaucoma, Cancer and Osteoporosis.
- Authors
Carradori, Simone; Mollica, Adriano; De Monte, Celeste; Granese, Arianna; Supuran, Claudiu T.
- Abstract
Due to the recognized biological role of nitric oxide (NO) donating derivatives and of selective inhibitors of specific human carbonic anhydrase isoforms (CA, EC 4.2.1.1), promising compounds having an aromatic/heterocyclic primary sulfonamide and functionalized with NO-releasing moieties have been designed. These bifunctional agents have been tested in vitro and in vivo to assess their dual pharmacological activity. According to the encouraging results they could be proposed for the treatment of angle-open glaucoma, cancer regression and osteoporosis, in which both NO and CA activities are involved.
- Subjects
NITRIC oxide; CARBONIC anhydrase inhibitors; GLAUCOMA treatment; CANCER treatment; OSTEOPOROSIS treatment; PHARMACOLOGY
- Publication
Molecules, 2015, Vol 20, Issue 4, p5667
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules20045667