Works matching DE "DNA alkylation"

Results: 123

Photoinduced DNA Interstrand Cross‐Linking by 1,1′‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 16, p. 5215, doi. 10.1002/chem.202005064

By:

Fan, Heli;
Sun, Huabing;
Zhang, Qi;
Peng, Xiaohua

Publication type:

Article

Evaluation of the DNA Alkylation Properties of a Chlorambucil‐Conjugated Cyclic Pyrrole‐Imidazole Polyamide.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 8, p. 2782, doi. 10.1002/chem.202004421

By:

Hirose, Yuki;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

DNA Alkylation of the RUNX‐Binding Sequence by CBI–PI Polyamide Conjugates**.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 64, p. 14639, doi. 10.1002/chem.202002166

By:

Maeda, Rina;
Ito, Shinji;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

Photo-Cross-Linking Probes for Trapping G-Quadruplex DNA.

Published in:

Angewandte Chemie, 2014, v. 126, n. 4, p. 1012, doi. 10.1002/ange.201307413

By:

Verga, Daniela;
Hamon, Florian;
Poyer, Florent;
Bombard, Sophie;
Teulade ‐ Fichou, Marie ‐ Paule

Publication type:

Article

Transcriptional outcome of telomere signalling.

Published in:

Nature Reviews Genetics, 2014, v. 15, n. 7, p. 491, doi. 10.1038/nrg3743

By:

Ye, Jing;
Renault, Valérie M.;
Jamet, Karine;
Gilson, Eric

Publication type:

Article

A systematic review on multipotent carcinogenic agent, N‐nitrosodiethylamine (NDEA), its major risk assessment, and precautions.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 8, p. 1108, doi. 10.1002/jat.4574

By:

Janmeda, Pracheta;
Jain, Divya;
Chaudhary, Priya;
Meena, Mukesh;
Singh, Devendra

Publication type:

Article

The Mechanism of Action of Cyclophosphamide and Its Consequences for the Development of a New Generation of Oxazaphosphorine Cytostatics.

Published in:

Scientia Pharmaceutica, 2020, v. 88, n. 4, p. 1, doi. 10.3390/scipharm88040042

By:

Voelcker, Georg

Publication type:

Article

Synthesis of DOHNAA, a Mycobacterium tuberculosis Cholesterol CD Ring Catabolite and FadD3 Substrate.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 27, p. 6075, doi. 10.1002/ejoc.201500698

By:

Stubbing, Louise A.;
Lott, J. Shaun;
Dawes, Stephanie S.;
Furkert, Daniel P.;
Brimble, Margaret A.

Publication type:

Article

Synthesis and DNA-Damaging Properties of Cisplatin-N-Mustard Conjugates.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 12, p. 2654, doi. 10.1002/ejoc.201500144

By:

Schiesser, Stefan;
Hackner, Benjamin;
Vrabel, Milan;
Beck, Wolfgang;
Carell, Thomas

Publication type:

Article

Interdependent Sequence Selectivity and Diastereoselectivity in the Alkylation of DNA by Decarbamoylmitomycin C.

Published in:

Chemistry - A European Journal, 2018, v. 24, n. 50, p. 13278, doi. 10.1002/chem.201802038

By:

Aguilar, William;
Paz, Manuel M.;
Vargas, Anayatzinc;
Zheng, Maggie;
Cheng, Shu‐yuan;
Champeil, Elise

Publication type:

Article

4,5-Dihydro-1,2,3-oxadiazole: A Very Elusive Key Intermediate in Various Important Chemical Transformations.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 43, p. 15092, doi. 10.1002/chem.201502326

By:

Banert, Klaus;
Singh, Neeraj;
Fiedler, Benjamin;
Friedrich, Joachim;
Korb, Marcus;
Lang, Heinrich

Publication type:

Article

In Memoriam: Maria Ciaramella (1958–2018).

Published in:

2019

By:

Perugino, Giuseppe;
Valenti, Anna;
Cobucci-Ponzano, Beatrice;
Moracci, Marco;
Rossi, Mosè

Publication type:

Announcement

Erratum to: A novel thermostable protein-tag: optimization of the Sulfolobus solfataricus DNA-alkyl-transferase by protein engineering.

Published in:

2016

By:

Vettone, Antonella;
Serpe, Mario;
Hidalgo, Aurelio;
Berenguer, José;
Monaco, Giovanni;
Valenti, Anna;
Rossi, Mosé;
Ciaramella, Maria;
Perugino, Giuseppe

Publication type:

Erratum

Versatile cell-based assay for measuring DNA alkylation damage and its repair.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-97523-w

By:

Li, Yong;
Mao, Peng;
Basenko, Evelina Y.;
Lewis, Zachary;
Smerdon, Michael J.;
Czaja, Wioletta

Publication type:

Article

Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1415266

By:

Göller, Andreas H.;
Johanssen, Sandra;
Zalewski, Adam;
Ziegler, Verena

Publication type:

Article

Shiga Toxin 1, as DNA Repair Inhibitor, Synergistically Potentiates the Activity of the Anticancer Drug, Mafosfamide, on Raji Cells.

Published in:

Toxins, 2013, v. 5, n. 2, p. 431, doi. 10.3390/toxins5020431

By:

Brigotti, Maurizio;
Arfilli, Valentina;
Carnicelli, Domenica;
Rocchi, Laura;
Calcabrini, Cinzia;
Ricci, Francesca;
Pagliaro, Pasqualepaolo;
Tazzari, Pier Luigi;
Alfieri, Roberta R.;
Petronini, Pier Giorgio;
Sestili, Piero

Publication type:

Article

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Published in:

Science Signaling, 2019, v. 12, n. 568, p. N.PAG, doi. 10.1126/scisignal.aau9216

By:

Allocca, Mariacarmela;
Corrigan, Joshua J.;
Mazumder, Aprotim;
Fake, Kimberly R.;
Samson, Leona D.

Publication type:

Article

Effect of Natural and Semisynthetic Pseudoguianolides on the Stability of NF-κB:DNA Complex Studied by Agarose Gel Electrophoresis.

Published in:

PLoS ONE, 2015, v. 10, n. 1, p. 1, doi. 10.1371/journal.pone.0115819

By:

Villagomez, Rodrigo;
Hatti-Kaul, Rajni;
Sterner, Olov;
Almanza, Giovanna;
Linares-Pastén, Javier A.

Publication type:

Article

Stable Cellular Senescence Is Associated with Persistent DDR Activation.

Published in:

PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0110969

By:

Fumagalli, Marzia;
Rossiello, Francesca;
Mondello, Chiara;
d’Adda di Fagagna, Fabrizio

Publication type:

Article

Analysis of the Tolerance to DNA Alkylating Damage in MEC1 and RAD53 Checkpoint Mutants of Saccharomyces cerevisiae.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081108

By:

Gallego-Sánchez, Alfonso;
Ufano, Sandra;
Andrés, Sonia;
Bueno, Avelino

Publication type:

Article

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0076198

By:

Mielecki, Damian;
Saumaa, Signe;
Wrzesiński, Michał;
Maciejewska, Agnieszka M.;
Żuchniewicz, Karolina;
Sikora, Anna;
Piwowarski, Jan;
Nieminuszczy, Jadwiga;
Kivisaar, Maia;
Grzesiuk, Elżbieta

Publication type:

Article

ALKBH1 Is Dispensable for Abasic Site Cleavage during Base Excision Repair and Class Switch Recombination.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0067403

By:

Müller, Tina A.;
Yu, Kefei;
Hausinger, Robert P.;
Meek, Katheryn

Publication type:

Article

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047978

By:

Éthier, Chantal;
Tardif, Maxime;
Arul, Laura;
Poirier, Guy G.

Publication type:

Article

Cover Feature: Understanding the Alkylation Mechanism of 3‐Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions (Eur. J. Org. Chem. 44/2021).

Published in:

European Journal of Organic Chemistry, 2021, v. 2021, n. 44, p. 5896, doi. 10.1002/ejoc.202101371

By:

Helbing, Tim;
Georg, Mats;
Stöhr, Fabian;
Carraro, Caterina;
Becker, Jonathan;
Gatto, Barbara;
Göttlich, Richard

Publication type:

Article

Understanding the Alkylation Mechanism of 3‐Chloropiperidines – NMR Kinetic Studies and Isolation of Bicyclic Aziridinium Ions.

Published in:

European Journal of Organic Chemistry, 2021, v. 2021, n. 44, p. 5905, doi. 10.1002/ejoc.202101072

By:

Helbing, Tim;
Georg, Mats;
Stöhr, Fabian;
Carraro, Caterina;
Becker, Jonathan;
Gatto, Barbara;
Göttlich, Richard

Publication type:

Article

Synthesis of 2‐Chloro‐3‐amino indenone derivatives and their evaluation as inhibitors of DNA dealkylation repair.

Published in:

Chemical Biology & Drug Design, 2021, v. 97, n. 6, p. 1170, doi. 10.1111/cbdd.13839

By:

Nigam, Richa;
Raveendra Babu, Kaki;
Ghosh, Topi;
Kumari, Bhavini;
Das, Prolay;
Anindya, Roy;
Ahmed Khan, Faiz

Publication type:

Article

Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF‐7 and K562 cancer cells.

Published in:

Chemical Biology & Drug Design, 2018, v. 92, n. 6, p. 2022, doi. 10.1111/cbdd.13374

By:

Cheng, Shu‐Yuan;
Vargas, Anayatzinc;
Lee, Ji‐Young;
Clement, Cristina C.;
Champeil, Elise

Publication type:

Article

Synthesis and Antiviral Properties of Spirocyclic [1,2,3]-Triazolooxazine Nucleosides.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 37, p. 11685, doi. 10.1002/chem.201403560

By:

Dell'Isola, Antonio;
McLachlan, Matthew M. W.;
Neuman, Benjamin W.;
Al ‐ Mullah, Hawaa M. N.;
Binks, Alexander W. D.;
Elvidge, Warren;
Shankland, Kenneth;
Cobb, Alexander J. A.

Publication type:

Article

Aromatic Nitrogen Mustard-Based Prodrugs: Activity, Selectivity, and the Mechanism of DNA Cross-Linking.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 24, p. 7410, doi. 10.1002/chem.201400090

By:

Chen, Wenbing;
Han, Yanyan;
Peng, Xiaohua

Publication type:

Article

Sequence-Specific DNA Alkylation Targeting for Kras Codon 13 Mutation by Pyrrole–Imidazole Polyamide seco-CBI Conjugates.

Published in:

Chemistry - A European Journal, 2014, v. 20, n. 5, p. 1310, doi. 10.1002/chem.201303295

By:

Taylor, Rhys Dylan;
Asamitsu, Sefan;
Takenaka, Tomohiro;
Yamamoto, Makoto;
Hashiya, Kaori;
Kawamoto, Yusuke;
Bando, Toshikazu;
Nagase, Hiroki;
Sugiyama, Hiroshi

Publication type:

Article

Hydrogen Bonding or Stacking Interactions in Differentiating Duplex Stability in Oligonucleotides Containing Synthetic Nucleoside Probes for Alkylated DNA.

Published in:

Chemistry - A European Journal, 2013, v. 19, n. 33, p. 11062, doi. 10.1002/chem.201204593

By:

Gahlon, Hailey L.;
Sturla, Shana J.

Publication type:

Article

Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2.

Published in:

Magnetic Resonance in Chemistry, 2017, v. 55, n. 2, p. 128, doi. 10.1002/mrc.4508

By:

Naumczuk, Beata;
Kawęcki, Robert;
Bocian, Wojciech;
Bednarek, Elżbieta;
Sitkowski, Jerzy;
Kozerski, Lech

Publication type:

Article

Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.

Published in:

Archives of Toxicology, 2019, v. 93, n. 2, p. 559, doi. 10.1007/s00204-018-2355-0

By:

Kraus, Alexander;
McKeague, Maureen;
Seiwert, Nina;
Nagel, Georg;
Geisen, Susanne M.;
Ziegler, Nathalie;
Trantakis, Ioannis A.;
Kaina, Bernd;
Thomas, Adam D.;
Sturla, Shana J.;
Fahrer, Jörg

Publication type:

Article

An evidence-based review of the genotoxic and reproductive effects of sulfur mustard.

Published in:

Archives of Toxicology, 2017, v. 91, n. 3, p. 1143, doi. 10.1007/s00204-016-1911-8

By:

Khan, Fazlullah;
Niaz, Kamal;
Ismail Hassan, Fatima;
Abdollahi, Mohammad

Publication type:

Article

Mutagenicity and toxicity of the DNA alkylation carcinogens 1, 2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium.

Published in:

Mutagenesis, 1996, v. 11, n. 3, p. 241, doi. 10.1093/mutage/11.3.241

By:

Wei, Xiao;
Nowak, Malgorzata;
Laferte, Suzanne;
Fontanie, Treena

Publication type:

Article

Analysis of DNA alkylation damage and repair in mammalian cells by the comet assay.

Published in:

Mutagenesis, 1996, v. 11, n. 2, p. 169, doi. 10.1093/mutage/11.2.169

By:

Fortini, P.;
Raspaglio, G.;
Falchi, M.;
Dogliotti, E.

Publication type:

Article

Regulation of the DNA damage response by ubiquitin conjugation.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00098

By:

Brinkmann, Kerstin;
Schell, Michael;
Hoppe, Thorsten;
Kashkar, Hamid

Publication type:

Article

DDR-mediated crosstalk between DNA-damaged cells and their microenvironment.

Published in:

Frontiers in Genetics, 2015, v. 6, p. 1, doi. 10.3389/fgene.2015.00094

By:

Malaquin, Nicolas;
Carrier-Leclerc, Audrey;
Dessureault, Mireille;
Rodier, Francis

Publication type:

Article

Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea.

Published in:

Genes & Environment, 2019, v. 41, n. 1, p. 1, doi. 10.1186/s41021-019-0137-4

By:

Inami, Keiko;
Asada, Yoshihisa;
Harada, Takumi;
Okayama, Yuta;
Usui, Noriko;
Mochizuki, Masataka

Publication type:

Article

Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli.

Published in:

Genes & Environment, 2019, v. 41, n. 1, p. N.PAG, doi. 10.1186/s41021-019-0123-x

By:

Yamada, Yoko;
Watanabe, Shinji;
Okamoto, Keinosuke;
Arimoto, Sakae;
Takahashi, Eizo;
Negishi, Kazuo;
Negishi, Tomoe

Publication type:

Article

Study of the Physiological Alterations Induced by Cisplatin in Miceandthe Possible Protective Role of Green Tea.

Published in:

International Journal of Pharmacy & Life Sciences, 2018, v. 9, n. 2, p. 5722

By:

Mohamed, Idriss H.

Publication type:

Article

ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration.

Published in:

Cell & Bioscience, 2024, v. 14, n. 1, p. 1, doi. 10.1186/s13578-024-01264-y

By:

Lei, Yu;
Zhan, Enyu;
Chen, Chao;
Hu, Yaoquan;
Lv, Zhengpin;
He, Qicong;
Wang, Xuenan;
Li, Xingguo;
Zhang, Fan

Publication type:

Article

Sequence-Specific DNA Alkylation by Tandem Py-Im Polyamide Conjugates.

Published in:

Chemistry - An Asian Journal, 2014, v. 9, n. 9, p. 2527, doi. 10.1002/asia.201402331

By:

Taylor, Rhys Dylan;
Kawamoto, Yusuke;
Hashiya, Kaori;
Bando, Toshikazu;
Sugiyama, Hiroshi

Publication type:

Article

In silico profiling and structural insights of zinc metal ion on O6-methylguanine methyl transferase and its interactions using molecular dynamics approach.

Published in:

Journal of Molecular Modeling, 2021, v. 27, n. 2, p. 1, doi. 10.1007/s00894-020-04631-x

By:

Gharouni, Marzieh;
Mosaddeghi, Hamid;
Mehrzad, Jamshid;
Es-haghi, Ali;
Motavalizadehkakhky, Alireza

Publication type:

Article

Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study.

Published in:

Journal of Molecular Modeling, 2013, v. 19, n. 1, p. 383, doi. 10.1007/s00894-012-1557-2

By:

Senthilnathan, Dhurairajan;
Kalaiselvan, Anbarasan;
Venuvanalingam, Ponnambalam

Publication type:

Article

Preclinical bioavailability-bioequivalence and toxico-kinetic profile of stable succinc acid cocrystal of temozolomide.

Published in:

Current Science (00113891), 2015, v. 108, n. 6, p. 1097

By:

Sravani, Edula;
Mannava, M. K. Chaitanya;
Kaur, Damandeep;
Annapurna, B. R.;
Khan, Ronaq Ali;
Suresh, Kuthuru;
Mittapalli, Sudhir;
Nangia, Ashwini;
Kumar, B. Dinesh

Publication type:

Article

Introducing AOP Reports: Collaborative review and publication of adverse outcome pathways.

Published in:

Environmental & Molecular Mutagenesis, 2022, v. 63, n. 3, p. 116, doi. 10.1002/em.22481

By:

O'Brien, Jason M.;
Yauk, Carole L.

Publication type:

Article

Development of the adverse outcome pathway 'alkylation of DNA in male premeiotic germ cells leading to heritable mutations' using the OECD's users' handbook supplement.

Published in:

Environmental & Molecular Mutagenesis, 2015, v. 56, n. 9, p. 724, doi. 10.1002/em.21954

By:

Yauk, Carole L.;
Lambert, Iain B.;
Meek, M.E. (Bette);
Douglas, George R.;
Marchetti, Francesco

Publication type:

Article

The NuA4 Complex Promotes Translesion Synthesis (TLS)-Mediated DNA Damage Tolerance.

Published in:

Genetics, 2015, v. 199, n. 4, p. 1065, doi. 10.1534/genetics.115.174490

By:

Renaud-Young, Margaret;
Lloyd, David C.;
Chatfield-Reed, Kate;
George, Iain;
Chua, Gordon;
Cobb, Jennifer

Publication type:

Article

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53.

Published in:

Scientific Reports, 2015, p. 15798, doi. 10.1038/srep15798

By:

Shin, Hyeon-Jun;
Kwon, Hyuk-Kwon;
Lee, Jae-Hyeok;
Gui, Xiangai;
Achek, Asma;
Kim, Jae-Ho;
Choi, Sangdun

Publication type:

Article