We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents.
- Authors
Gil, Ana; Pabón, Adriana; Galiano, Silvia; Burguete, Asunción; Pérez-Silanes, Silvia; Deharo, Eric; Monge, Antonio; Aldana, Ignacio
- Abstract
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
- Subjects
MALARIA treatment; QUINOXALINES; HETEROCYCLIC compounds; PLASMODIUM falciparum; CARBONYL compounds
- Publication
Molecules, 2014, Vol 19, Issue 2, p2166
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules19022166