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- Title
New Quinoxaline Derivatives as Potential MT<sub>1</sub> and MT<sub>2</sub> Receptor Ligands.
- Authors
Ancizu, Saioa; Castrillo, Nerea; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Delagrange, Philippe; Caignard, Daniel-Henry; Galiano, Silvia
- Abstract
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.
- Subjects
QUINOXALINES; LIGANDS (Biochemistry); MELATONIN; SLEEP disorders; DRUG receptors; METHOXY group
- Publication
Molecules, 2012, Vol 17, Issue 7, p7737
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules17077737