Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages.

Szliszka, Ewelina; Skaba, Dariusz; Czuba, Zenon P.; Krol, Wojciech

Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS IFN-γ- or PMA- stimulated RAW264.7 macrophages.

FLAVONOIDS; COUMARINS; PSORALEA; LEGUMES; OXYGEN

Molecules, 2011, Vol 16, Issue 5, p3701

1420-3049

Academic Journal

10.3390/molecules16053701