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- Title
Heterocyclic-2-carboxylic Acid (3-Cyano-1,4-di-Noxidequinoxalin-2-yl)amide Derivatives as Hits for the Development of Neglected Disease Drugs.
- Authors
Ancizu, Saioa; Moreno, Elsa; Torres, Enrique; Burguete, Asunción; Pérez-Silanes, Silvia; Benítez, Diego; Villar, Raquel; Solano, Beatriz; Marín, Adoración; Aldana, Ignacio; Cerecetto, Hugo; González, Mercedes; Monge, Antonio
- Abstract
Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order as the anti-chagasic drug, nifurtimox.
- Subjects
CARBOXYLIC acids; TUBERCULOSIS treatment; CHAGAS' disease treatment; QUINOXALINES; RIFAMPIN; MYCOBACTERIUM tuberculosis; TRYPANOSOMA cruzi; MYCOBACTERIAL diseases; THERAPEUTICS
- Publication
Molecules, 2009, Vol 14, Issue 6, p2256
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules14062256