Works matching DE "TETRAHYDROFOLATE dehydrogenase"

Results: 528

Comprehensive analysis of molecular markers linked to antimalarial drug resistance in Plasmodium falciparum in Northern, Northeastern and Eastern Uganda.

Published in:

Malaria Journal, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12936-025-05439-x

By:

Olupot-Olupot, Peter;
Paasi, George;
Katairo, Thomas;
Alunyo, Jimmy Patrick;
Nakiyemba, Alice;
Ocen, Gilbert Gilibrays;
Pande, Stephen;
Alaroker, Florance;
Okiror, William;
Ocen, Emmaluel;
Oula, Alex;
Okalebo, Charles Benard;
Paul, Ongodia;
Amorut, Denis;
Tukwasibwe, Stephen;
Ndidde, Susan Nabadda;
Sewanyana, Isaac;
Nsobya, Samuel L.

Publication type:

Article

Efficient Searches in Protein Sequence Space Through AI-Driven Iterative Learning.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 10, p. 4741, doi. 10.3390/ijms26104741

By:

Suárez-Martín, Ignacio;
Risso, Valeria A.;
Romero-Zaliz, Rocío;
Sanchez-Ruiz, Jose M.

Publication type:

Article

Divergent evolution of protein conformational dynamics in dihydrofolate reductase.

Published in:

Nature Structural & Molecular Biology, 2013, v. 20, n. 11, p. 1243, doi. 10.1038/nsmb.2676

By:

Bhabha, Gira;
Ekiert, Damian C;
Jennewein, Madeleine;
Zmasek, Christian M;
Tuttle, Lisa M;
Kroon, Gerard;
Dyson, H Jane;
Godzik, Adam;
Wilson, Ian A;
Wright, Peter E

Publication type:

Article

A paternal effect of MTHFR SNPs on gametes and embryos should not be overlooked: case reports.

Published in:

Journal of Assisted Reproduction & Genetics, 2019, v. 36, n. 7, p. 1351, doi. 10.1007/s10815-019-01488-9

By:

Jacquesson-Fournols, Laetitia;
Alvarez, Silvia;
Cohen, Marc;
Clement, Patrice;
Menezo, Yves

Publication type:

Article

Cover Feature: Thermal Adaptation of Enzymes: Impacts of Conformational Shifts on Catalytic Activation Energy and Optimum Temperature (Chem. Eur. J. 44/2020).

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 44, p. 9657, doi. 10.1002/chem.202003018

By:

Maffucci, Irene;
Laage, Damien;
Sterpone, Fabio;
Stirnemann, Guillaume

Publication type:

Article

Thermal Adaptation of Enzymes: Impacts of Conformational Shifts on Catalytic Activation Energy and Optimum Temperature.

Published in:

Chemistry - A European Journal, 2020, v. 26, n. 44, p. 10045, doi. 10.1002/chem.202001973

By:

Maffucci, Irene;
Laage, Damien;
Sterpone, Fabio;
Stirnemann, Guillaume

Publication type:

Article

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Published in:

Angewandte Chemie, 2015, v. 127, n. 31, p. 9144, doi. 10.1002/ange.201503968

By:

Luk, Louis Y. P.;
Ruiz-Pernía, J. Javier;
Adesina, Aduragbemi S.;
Loveridge, E. Joel;
Tuñón, Iñaki;
Moliner, Vincent;
Allemann, Rudolf K.

Publication type:

Article

Cell-Mediated Assembly of Phototherapeutics.

Published in:

Angewandte Chemie, 2014, v. 126, n. 41, p. 11125, doi. 10.1002/ange.201406216

By:

Smith, Weston J.;
Oien, Nathan P.;
Hughes, Robert M.;
Marvin, Christina M.;
Rodgers, Zachary L.;
Lee, Junghyun;
Lawrence, David S.

Publication type:

Article

SpyTag/SpyCatcher Cyclization Confers Resilience to Boiling on a Mesophilic Enzyme.

Published in:

Angewandte Chemie, 2014, v. 126, n. 24, p. 6215, doi. 10.1002/ange.201402519

By:

Schoene, Christopher;
Fierer, Jacob O.;
Bennett, S. Paul;
Howarth, Mark

Publication type:

Article

Effect and Mechanism of Cotrimoxazole Against Talaromyces marneffei in vitro.

Published in:

Mycopathologia, 2022, v. 187, n. 5/6, p. 579, doi. 10.1007/s11046-022-00673-2

By:

Chen, Jie;
Chen, Rongfeng;
Wei, Wudi;
Qin, Fengxiang;
Chen, Xiu;
He, Jinhao;
Zhang, Hong;
Wang, Gang;
Shi, Minjuan;
Qin, Tongxue;
Liao, Yinlu;
Wu, Yuting;
Lu, Beibei;
Tao, Xing;
Ye, Li;
Liang, Hao;
Jiang, Junjun

Publication type:

Article

Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 92, n. 4, p. 779, doi. 10.1007/s00253-011-3475-0

By:

Jeon, Min;
Yu, Da;
Lee, Gyun

Publication type:

Article

Carriage of Mutant Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Plasmodium falciparum Isolates Recovered from Pregnant Women with Asymptomatic Infection in Lagos, Nigeria.

Published in:

Medical Principles & Practice, 2015, v. 24, n. 5, p. 436, doi. 10.1159/000430987

By:

Iwalokun, Bamidele abiodun;
Iwalokun, Senapon O.;
adebodun, Victor;
Balogun, Modinat

Publication type:

Article

MODELING OF NEW POTENTIAL INHIBITORS OF DIHYDROFOLATE REDUCTASE BASED ON 1,3,4-TH I AD I AZ OLE AMIDOALKYL DERIVATIVES.

Published in:

Issues of Chemistry & Chemical Technology / Voprosy Khimii & Khimicheskoi Tekhnologii, 2023, n. 5, p. 91, doi. 10.32434/0321-4095-2023-150-5-91-97

By:

Pavlova, V. V.;
Zadorotftnii, P. V.;
Kiselev, V. V.;
Kharchenko, A. V.;
Okhtina, O. V.

Publication type:

Article

Pralatrexate represses the resistance of HCC cells to molecular targeted agents via the miRNA-34a/Notch pathway.

Published in:

Discover Oncology, 2024, v. 15, n. 1, p. 1, doi. 10.1007/s12672-024-01572-2

By:

Jin, Yang;
Liu, Qiming;
Sun, Baisheng;
Li, Xiaokang;
Wu, Jiahao;
Lin, Zhiyuan;
Ma, Yan;
Jia, Haijiang

Publication type:

Article

Phytochemical, Antimicrobial, Antioxidant, and In Vitro Cytotoxicity Evaluation of Echinops erinaceus Kit Tan.

Published in:

Separations (2297-8739), 2022, v. 9, n. 12, p. 447, doi. 10.3390/separations9120447

By:

Sweilam, Sherouk Hussein;
Abdel Bar, Fatma M.;
Foudah, Ahmed I.;
Alqarni, Mohammed H.;
Elattal, Nouran A.;
El-Gindi, Omayma D.;
El-Sherei, Moshera M.;
Abdel-Sattar, Essam

Publication type:

Article

Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03384-y

By:

Krucinska, Jolanta;
Lombardo, Michael N.;
Erlandsen, Heidi;
Estrada, Alexavier;
Si, Debjani;
Viswanathan, Kishore;
Wright, Dennis L.

Publication type:

Article

The aminosalicylate - folate connection.

Published in:

Drug Metabolism Reviews, 2024, v. 56, n. 1, p. 80, doi. 10.1080/03602532.2024.2303507

By:

London, Robert E.

Publication type:

Article

Taurine and enzymatically modified isoquercitrin protected against methotrexate‐induced deteriorations in the conductivity and rhythmicity of the heart in rats: Antioxidant, anti‐inflammatory, and histological architecture approach.

Published in:

Journal of Applied Toxicology, 2024, v. 44, n. 12, p. 1924, doi. 10.1002/jat.4682

By:

Mahmoud, Marwa M.;
El‐Batran, Seham A.;
Hegazy, Rehab;
El‐Sayed, Wael M.

Publication type:

Article

In Silico Study Probes Potential Inhibitors of Human Dihydrofolate Reductase for Cancer Therapeutics.

Published in:

Journal of Clinical Medicine, 2019, v. 8, n. 2, p. 233, doi. 10.3390/jcm8020233

By:

Rana, Rabia Mukhtar;
Rampogu, Shailima;
Zeb, Amir;
Son, Minky;
Park, Chanin;
Lee, Gihwan;
Yoon, Sanghwa;
Baek, Ayoung;
Parameswaran, Sarvanan;
Park, Seok Ju;
Lee, Keun Woo

Publication type:

Article

Chemical Composition, In Silico Investigations and Evaluation of Antifungal, Antibacterial, Insecticidal and Repellent Activities of Eucalyptus camaldulensis Dehn. Leaf Essential Oil from ALGERIA.

Published in:

Plants (2223-7747), 2024, v. 13, n. 22, p. 3229, doi. 10.3390/plants13223229

By:

Barboucha, Ghozlane;
Rahim, Noureddine;
Boulebd, Houssem;
Bramki, Amina;
Andolfi, Anna;
Salvatore, Maria Michela;
Masi, Marco

Publication type:

Article

Evaluating the Functional Pore Size of Chloroplast TOC and TIC Protein Translocons: Import of Folded Proteins.

Published in:

Plant Cell, 2018, v. 30, n. 9, p. 2161, doi. 10.1105/tpc.18.00427

By:

Ganesan, Iniyan;
Shi, Lan-Xin;
Labs, Mathias;
Theg, Steven M.

Publication type:

Article

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.

Published in:

Plant Cell, 2017, v. 29, n. 11, p. 2831, doi. 10.1105/tpc.17.00433

By:

Gorelova, Vera;
Lepeleire, Jolien De;
Daele, Jeroen Van;
Pluim, Dick;
Meï, Coline;
Cuypers, Ann;
Leroux, Olivier;
Rébeillé, Fabrice;
Schellens, Jan H.M.;
Blancquaert, Dieter;
Stove, Christophe P.;
Straeten, Dominique Van Der

Publication type:

Article

Folate Metabolism Linked to Redox Balance in Arabidopsis.

Published in:

Plant Cell, 2017, v. 29, n. 11, p. 2682, doi. 10.1105/tpc.17.00766

By:

Farquharson, Kathleen L.

Publication type:

Article

Determination of thymidine phosphorylase expression level facilitates recurrence risk stratification in stage II/III colorectal cancer following adjuvant chemotherapy with oral fluoropyrimidines.

Published in:

Oncology Letters, 2019, v. 17, n. 6, p. 5267

By:

Kugimiya, Naruji;
Harada, Eijiro;
Suehiro, Yuki;
Suga, Atsushi;
Takemoto, Yoshihiro;
Hamano, Kimikazu

Publication type:

Article

Clinical efficacy and mechanism of Pralatrexate combined with Palbociclib Isethionate in treatment of bladder cancer patients.

Published in:

Oncology Letters, 2019, v. 17, n. 1, p. 201

By:

Wang, Xiaobin;
Wang, Huihan;
Song, Yongsheng

Publication type:

Article

Overexpression of dihydrofolate reductase is a factor of poor survival in acute lymphoblastic leukemia.

Published in:

Oncology Letters, 2018, v. 15, n. 6, p. 8405, doi. 10.3892/ol.2018.8429

By:

Organista-Nava, Jorge;
Gómez-Gómez, Yazmín;
Illades-Aguiar, BerENice;
Rivera-Ramírez, Ana Bertha;
Saavedra-Herrera, Mónica Virginia;
Leyva-Vázquez, Marco Antonio

Publication type:

Article

DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells.

Published in:

Oncology Letters, 2017, v. 14, n. 1, p. 171, doi. 10.3892/ol.2017.6132

By:

YU‑HSIEN LEE;
HUI‑WEN YANG;
LI‑CHIU YANG;
MING‑YI LU;
LO‑LIN TSAI;
YU‑FENG HUANG;
FANG‑WEI HU;
MING‑YUNG CHOU;
CHENG‑CHIA YU;
SHUN‑FA YANG

Publication type:

Article

Low androgen status inhibits erectile function by inducing eNOS uncoupling in rat corpus cavernosum.

Published in:

Andrology, 2020, v. 8, n. 6, p. 1875, doi. 10.1111/andr.12844

By:

Xiong, Wenju;
Kong, Xiangjun;
Jiang, Jun;
Yang, Zhihui;
Jiang, Rui

Publication type:

Article

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.

Published in:

Metabolites (2218-1989), 2023, v. 13, n. 2, p. 151, doi. 10.3390/metabo13020151

By:

Brown, Jennifer I.;
Wang, Peng;
Wong, Alan Y. L.;
Petrova, Boryana;
Persaud, Rosanne;
Soukhtehzari, Sepideh;
Lopez McDonald, Melanie;
Hanke, Danielle;
Christensen, Josephine;
Iliev, Petar;
Wang, Weiyuan;
Everton, Daniel K.;
Williams, Karla C.;
Frank, David A.;
Kanarek, Naama;
Page, Brent D. G.

Publication type:

Article

Folate Related Pathway Gene Analysis Reveals a Novel Metabolic Variant Associated with Alzheimer's Disease with a Change in Metabolic Profile.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 6, p. 475, doi. 10.3390/metabo12060475

By:

Miyan, Jaleel;
Buttercase, Charlotte;
Beswick, Emma;
Miyan, Salma;
Moshkdanian, Ghazaleh;
Naz, Naila

Publication type:

Article

Folic acid restricts SARS-CoV-2 invasion by methylating ACE2.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.980903

By:

Yuanzhou Zhang;
Yechun Pang;
Baiyin Xu;
Xingshi Chen;
Shunshun Liang;
Jingying Hu;
Xiaoying Luo

Publication type:

Article

Editorial: Intraspecies variability in apicomplexan parasites: epidemiology, traits and virulence.

Published in:

Frontiers in Cellular & Infection Microbiology, 2024, p. 1, doi. 10.3389/fcimb.2024.1497043

By:

Arranz-Solís, David;
Mukhopadhyay, Debanjan

Publication type:

Article

In vitro and in silico evaluation of antibacterial activities of different solvent extracts made from Sisymbrium irio L. seeds.

Published in:

Journal of Applied & Natural Science, 2024, v. 16, n. 3, p. 1344, doi. 10.31018/jans.v16i3.5802

By:

Tiwari, Madhurima;
Bhargava, Prachi

Publication type:

Article

Virtual screening and molecular dynamics simulation studies to predict the binding of Sisymbrium irio L. derived phytochemicals against Staphylococcus aureus dihydrofolate reductase (DHFR).

Published in:

Journal of Applied & Natural Science, 2022, v. 14, n. 4, p. 1297, doi. 10.31018/jans.v14i4.3641

By:

Tiwari, Madhurima;
Gupta, Sunita;
Bhargava, Prachi

Publication type:

Article

Standardization of virtual-screening and post-processing protocols relevant to in-silico drug discovery.

Published in:

3 Biotech, 2018, v. 8, n. 12, p. 1, doi. 10.1007/s13205-018-1523-5

By:

Gupta, Sunita;
Lynn, Andrew M.;
Gupta, Vibha

Publication type:

Article

Two‐ and Three‐dimensional Quantitative Structure‐activity Relationship Models Based on Conformer Structures.

Published in:

Molecular Informatics, 2021, v. 40, n. 3, p. 1, doi. 10.1002/minf.202000123

By:

Nitta, Fumika;
Kaneko, Hiromasa

Publication type:

Article

Initiator-Directed Transcription: Fission Yeast Nmtl Initiator Directs Preinitiation Complex Formation and Transcriptional Initiation.

Published in:

Genes, 2022, v. 13, n. 2, p. 256, doi. 10.3390/genes13020256

By:

Rojas, Diego A.;
Urbina, Fabiola;
Valenzuela-Pérez, Lucía;
Leiva, Lorenzo;
Miralles, Vicente J.;
Maldonado, Edio

Publication type:

Article

Genetic Variations Associated with Drug Resistance Markers in Asymptomatic Plasmodium falciparum Infections in Myanmar.

Published in:

Genes, 2019, v. 10, n. 9, p. 692, doi. 10.3390/genes10090692

By:

Zhao, Yan;
Liu, Ziling;
Soe, Myat Thu;
Wang, Lin;
Soe, Than Naing;
Wei, Huanping;
Than, Aye;
Aung, Pyae Linn;
Li, Yuling;
Zhang, Xuexing;
Hu, Yubing;
Wei, Haichao;
Zhang, Yangminghui;
Burgess, Jessica;
Siddiqui, Faiza A.;
Menezes, Lynette;
Wang, Qinghui;
Kyaw, Myat Phone;
Cao, Yaming;
Cui, Liwang

Publication type:

Article

Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Osteosarcoma in a Mexican Population.

Published in:

Pediatric Reports, 2024, v. 16, n. 3, p. 786, doi. 10.3390/pediatric16030066

By:

Enriquez-Maldonado, Irma G.;
Montes-Galindo, Daniel A.;
Ortiz-Lopez, Rocio;
Ojeda-Ibarra, Jesus;
Martinez-Fierro, Margarita L.;
Rodriguez-Sanchez, Iram P.;
Rojas-Martinez, Augusto;
Zavala-Pompa, Angel;
Sanchez-Ramirez, Carmen Alicia;
Hernandez-Rangel, Alejandra E.;
Sanchez-Meza, Karmina;
Garza-Veloz, Idalia;
Rodriguez-Hernandez, Alejandrina;
Delgado-Enciso, Ivan

Publication type:

Article

Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives.

Published in:

Scientia Pharmaceutica, 2017, v. 85, n. 4, p. 1, doi. 10.3390/scipharm85040037

By:

Kulatee, Suriyawut;
Toochinda, Pisanu;
Suksangpanomrung, Anotai;
Lawtrakul, Luckhana

Publication type:

Article

Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208850

By:

Sodolescu, Andreea;
Dian, Cyril;
Terradot, Laurent;
Bouzhir-Sima, Latifa;
Lestini, Roxane;
Myllykallio, Hannu;
Skouloubris, Stéphane;
Liebl, Ursula

Publication type:

Article

Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana.

Published in:

PLoS ONE, 2018, v. 13, n. 9, p. 1, doi. 10.1371/journal.pone.0204871

By:

Osei, Musah;
Ansah, Felix;
Matrevi, Sena A.;
Asante, Kwaku P.;
Awandare, Gordon A.;
Quashie, Neils B.;
Duah, Nancy O.

Publication type:

Article

pH plays a role in the mode of action of trimethoprim on Escherichia coli.

Published in:

PLoS ONE, 2018, v. 13, n. 7, p. 1, doi. 10.1371/journal.pone.0200272

By:

AlRabiah, Haitham;
Allwood, J. William;
Correa, Elon;
Xu, Yun;
Goodacre, Royston

Publication type:

Article

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.

Published in:

PLoS ONE, 2018, v. 13, n. 5, p. 1, doi. 10.1371/journal.pone.0197173

By:

Tobias, Andrew M.;
Toska, Dea;
Lange, Keith;
Eck, Tyler;
Bhat, Rohit;
Janson, Cheryl A.;
Rotella, David P.;
Gubler, Ueli;
Goodey, Nina M.

Publication type:

Article

Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population.

Published in:

Middle East Fertility Society Journal, 2025, v. 30, n. 1, p. 1, doi. 10.1186/s43043-025-00223-y

By:

Bousnane, Nour El Houda;
Abu Alhaija, Abed Alkarem;
Labed, Housna;
Fizazi, Anissa;
Dahmani, Chahinez Amira;
Fouad Sadiq, May

Publication type:

Article

Is methotrexate effective and safe in patients with psoriatic arthritis? A Cochrane Review summary with commentary.

Published in:

International Journal of Rheumatic Diseases, 2021, v. 24, n. 1, p. 132, doi. 10.1111/1756-185X.13988

By:

Grubišić, Frane

Publication type:

Article

Low-dose and high-dose methotrexate are two different drugs in practical terms.

Published in:

International Journal of Rheumatic Diseases, 2010, v. 13, n. 4, p. 288, doi. 10.1111/j.1756-185X.2010.01564.x

By:

MALAVIYA, Anand N.;
SHARMA, Amit;
AGARWAL, Divya;
KAPOOR, Sanjiv;
GARG, Shriram;
SAWHNEY, Sujata

Publication type:

Article

Biosynthesis of L‐5‐methyltetrahydrofolate by genetically engineered Escherichia coli.

Published in:

Microbial Biotechnology, 2022, v. 15, n. 11, p. 2758, doi. 10.1111/1751-7915.14139

By:

Wang, Yubo;
Zhang, Meng;
Li, Lexin;
Yi, Jihong;
Liang, Jiyu;
Wang, Shuning;
Xu, Ping

Publication type:

Article

Class 1 and class 2 integrons in multidrug-resistant gram-negative bacteria isolated from the Salmon River, British Columbia.

Published in:

Canadian Journal of Microbiology, 2011, v. 57, n. 6, p. 460, doi. 10.1139/w11-029

By:

Xu, Hai;
Broersma, Klaas;
Miao, Vivian;
Davies, Julian

Publication type:

Article

Recent Cutting‐Edge Designing Strategies for Mtb‐DHFR Inhibitors as Antitubercular Agents.

Published in:

Chemical Biology & Drug Design, 2024, v. 104, n. 6, p. 1, doi. 10.1111/cbdd.70027

By:

Sonawane, Nitin Govind;
Thakur, Amrita;
Pillai, Anil Kumar Sasidharan;
Sharma, Ajay;
Gunjal, Amol Pandurang;
Sharma, Kalicharan

Publication type:

Article