We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411.
- Authors
Chen, Yi; Cai, Jian; Xia, Ziwei; Chen, Chunmei; Liu, Yonghong; Jayasinghe, Lalith; Wang, Xueni; Zhou, Xuefeng
- Abstract
Three new polyketides, including three ester derivatives (1, 3, and 5) and a new natural product, which was a benzoquinone derivative, embelin A (4), together with nine known ones (2 and 6–13), were isolated from the mangrove-derived fungus Penicillium sp. SCSIO 41411. Their structures were determined by detailed NMR and MS spectroscopic analyses. The X-ray single-crystal diffraction analysis of 4 was described for the first time. Compound 9 displayed obvious inhibition against PDE4 with an inhibitory ratio of 40.78% at 10 μM. Compound 12 showed DPPH radical scavenging activity, with an EC50 of 16.21 µg/mL, compared to the positive control (ascorbic acid, EC50, 11.22 µg/mL). Furthermore, compound 4 exhibited cytotoxicity against PC-3 and LNCaP with IC50 values of 18.69 and 31.62 µM, respectively.
- Subjects
ESTER derivatives; CYTOTOXINS; VITAMIN C; NATURAL products; BENZOQUINONES; POLYKETIDES
- Publication
Marine Drugs, 2024, Vol 22, Issue 9, p384
- ISSN
1660-3397
- Publication type
Academic Journal
- DOI
10.3390/md22090384