Title: Eunicellin-Based Diterpenoids, Hirsutalins N-R, from the Formosan Soft Coral Cladiella hirsuta.
Authors: Huang, Tzu-Zin; Chen, Bo-Wei; Huang, Chiung-Yao; Hwang, Tsong-Long; Dai, Chang-Feng; Sheu, Jyh-Horng
Abstract: New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
Subjects: ALCYONACEA; METABOLITE analysis; SPECTROSCOPIC imaging; CANCER cells; SUPEROXIDES; NEUTROPHILS
Publication: Marine Drugs, 2014, Vol 12, Issue 9, p2446
ISSN: 1660-3397
Publication type: Academic Journal
DOI: 10.3390/md12052446

Eunicellin-Based Diterpenoids, Hirsutalins N-R, from the Formosan Soft Coral Cladiella hirsuta.

Huang, Tzu-Zin; Chen, Bo-Wei; Huang, Chiung-Yao; Hwang, Tsong-Long; Dai, Chang-Feng; Sheu, Jyh-Horng