Title: Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review.
Authors: Zare, Afshin; Salehpour, Aria; Khoradmehr, Arezoo; Bakhshalizadeh, Shabnam; Najafzadeh, Vahid; Almasi-Turk, Sahar; Mahdipour, Mahdi; Shirazi, Reza; Tamadon, Amin
Abstract: More research is being conducted on myocardial cell treatments utilizing stem cell lines that can develop into cardiomyocytes. All of the forms of cardiac illnesses have shown to be quite amenable to treatments using embryonic (ESCs) and induced pluripotent stem cells (iPSCs). In the present study, we reviewed the differentiation of these cell types into cardiomyocytes from an epigenetic standpoint. We also provided a miRNA network that is devoted to the epigenetic commitment of stem cells toward cardiomyocyte cells and related diseases, such as congenital heart defects, comprehensively. Histone acetylation, methylation, DNA alterations, N6-methyladenosine (m6a) RNA methylation, and cardiac mitochondrial mutations are explored as potential tools for precise stem cell differentiation.
Subjects: EMBRYONIC stem cells; PLURIPOTENT stem cells; CONGENITAL heart disease; RNA methylation; EPIGENETICS; STEM cells
Publication: Life (2075-1729), 2023, Vol 13, Issue 2, p569
ISSN: 2075-1729
Publication type: Academic Journal
DOI: 10.3390/life13020569

Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review.

Zare, Afshin; Salehpour, Aria; Khoradmehr, Arezoo; Bakhshalizadeh, Shabnam; Najafzadeh, Vahid; Almasi-Turk, Sahar; Mahdipour, Mahdi; Shirazi, Reza; Tamadon, Amin