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- Title
Cheminformatic Identification of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibitors: A Comparative Study of SMILES-Based Supervised Machine Learning Models.
- Authors
Lai, Conan Hong-Lun; Kwok, Alex Pak Ki; Wong, Kwong-Cheong
- Abstract
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) repairs damages in DNA induced by abortive topoisomerase 1 activity; however, maintenance of genetic integrity may sustain cellular division of neoplastic cells. It follows that Tdp1-targeting chemical inhibitors could synergize well with existing chemotherapy drugs to deny cancer growth; therefore, identification of Tdp1 inhibitors may advance precision medicine in oncology.
- Publication
Journal of personalized medicine, 2024, Vol 14, Issue 9
- ISSN
2075-4426
- Publication type
Journal Article
- DOI
10.3390/jpm14090981