Title: Harnessing Synthetic Lethal Interactions for Personalized Medicine.
Authors: Shieh, Grace S.
Abstract: Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill cancer cells but leave normal cells intact. The applicability of translating this concept into clinics has been demonstrated by three drugs that have been approved by the FDA to target PARP for tumors bearing mutations in BRCA1/2. This article reviews applications of the SL concept to translational cancer medicine over the past five years. Topics are (1) exploiting the SL concept for drug combinations to circumvent tumor resistance, (2) using synthetic lethality to identify prognostic and predictive biomarkers, (3) applying SL interactions to stratify patients for targeted and immunotherapy, and (4) discussions on challenges and future directions.
Subjects: UNITED States. Food & Drug Administration; INDIVIDUALIZED medicine; CANCER genes; PROGNOSIS; TRANSLATIONAL research; POLY(ADP-ribose) polymerase
Publication: Journal of Personalized Medicine, 2022, Vol 12, Issue 1, p98
ISSN: 2075-4426
Publication type: Academic Journal
DOI: 10.3390/jpm12010098

Harnessing Synthetic Lethal Interactions for Personalized Medicine.

Shieh, Grace S.