Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.

van Tienhoven, Ximena A.; Ruiz de Chávez Gascón, Jimena; Cano-Herrera, Gabriela; Sarkis Nehme, José Antonio; Souroujon Torun, Ariela A.; Bautista Gonzalez, Maria Fernanda; Esparza Salazar, Felipe; Sierra Brozon, Ana; Rivera Rosas, Eder Gabriel; Carbajal Ocampo, Dante; Cabrera Carranco, Ramiro

Vitamin D (VD) is a fat-soluble steroid hormone with essential physiological functions beyond calcium and bone metabolism. In recent years, its role in women's reproductive health has gained attention, influencing ovarian function, follicular development, endometrial receptivity, and steroid hormone regulation. VD deficiency has been linked to reproductive disorders such as polycystic ovarian syndrome (PCOS), endometriosis, and infertility. Studies indicate that up to 40–50% of healthy pregnant women have insufficient VD levels, which may contribute to adverse pregnancy outcomes and reduced fertility. With growing evidence connecting VD to reproductive health, this review examines its molecular and endocrine mechanisms in fertility, endometriosis, and PCOS. It explores VD's therapeutic potential and its implications for improving clinical approaches and future research in reproductive medicine. Maintaining adequate VD levels is crucial for ovarian function, immune modulation in reproductive tissues, and overall fertility. Its deficiency is associated with insulin resistance, hormonal imbalances, and inflammatory processes, which contribute to reproductive pathophysiology. Establishing reference values for VD in reproductive medicine is essential for optimizing fertility treatments and improving clinical outcomes. This review synthesizes current research on VD's role in reproductive health and highlights the need for further investigation into its therapeutic applications.

VITAMIN D; HORMONE regulation; WOMEN'S health; PREGNANCY outcomes; BONE metabolism

International Journal of Molecular Sciences, 2025, Vol 26, Issue 5, p2256

1661-6596

Academic Journal

10.3390/ijms26052256