Results
Title

MicroRNAs in Hepatocellular Carcinoma Pathogenesis: Insights into Mechanisms and Therapeutic Opportunities.

Authors

Mahboobnia, Khadijeh; Beveridge, Dianne J.; Yeoh, George C.; Kabir, Tasnuva D.; Leedman, Peter J.

Abstract

Hepatocellular carcinoma (HCC) presents a significant global health burden, with alarming statistics revealing its rising incidence and high mortality rates. Despite advances in medical care, HCC treatment remains challenging due to late-stage diagnosis, limited effective therapeutic options, tumor heterogeneity, and drug resistance. MicroRNAs (miRNAs) have attracted substantial attention as key regulators of HCC pathogenesis. These small non-coding RNA molecules play pivotal roles in modulating gene expression, implicated in various cellular processes relevant to cancer development. Understanding the intricate network of miRNA-mediated molecular pathways in HCC is essential for unraveling the complex mechanisms underlying hepatocarcinogenesis and developing novel therapeutic approaches. This manuscript aims to provide a comprehensive review of recent experimental and clinical discoveries regarding the complex role of miRNAs in influencing the key hallmarks of HCC, as well as their promising clinical utility as potential therapeutic targets.

Subjects

NON-coding RNA; MEDICAL care; HEPATOCELLULAR carcinoma; THERAPEUTICS; DRUG delivery systems

Publication

International Journal of Molecular Sciences, 2024, Vol 25, Issue 17, p9393

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms25179393