miRNA in Ischemic Heart Disease and Its Potential as Biomarkers: A Comprehensive Review.

Kong, Amanda Shen-Yee; Lai, Kok-Song; Lim, Swee-Hua Erin; Sivalingam, Sivakumar; Loh, Jiun-Yan; Maran, Sathiya

Ischemic heart disease (IHD) constitutes the leading global cause of mortality and morbidity. Although significant progress has been achieved in the diagnosis, treatment, and prognosis of IHD, more robust diagnostic biomarkers and therapeutic interventions are still needed to circumvent the increasing incidence of IHD. MicroRNAs (miRNAs) are critical regulators of cardiovascular function and are involved in various facets of cardiovascular biology. While the knowledge of the role of miRNAs in IHD as diagnostic biomarkers has improved, research emphasis on how miRNAs can be effectively used for diagnosis and prognosis of IHD is crucial. This review provides an overview of the biology, therapeutic and diagnostic potential, as well as the caveats of using miRNAs in IHD based on existing research.

MYOCARDIAL ischemia; CORONARY disease; MICRORNA; BIOMARKERS

International Journal of Molecular Sciences, 2022, Vol 23, Issue 16, p9001

1661-6596

Academic Journal

10.3390/ijms23169001