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Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.
Published in:
Angewandte Chemie International Edition, 2016, v. 55, n. 5, p. 1719, doi. 10.1002/anie.201508755
By:
- Zhu, Rong;
- Sinwel, Doris;
- Hasenhuetl, Peter S.;
- Saha, Kusumika;
- Kumar, Vivek;
- Zhang, Peng;
- Rankl, Christian;
- Holy, Marion;
- Sucic, Sonja;
- Kudlacek, Oliver;
- Karner, Andreas;
- Sandtner, Walter;
- Stockner, Thomas;
- Gruber, Hermann J.;
- Freissmuth, Michael;
- Hauck Newman, Amy;
- Sitte, Harald H.;
- Hinterdorfer, Peter
Publication type:
Article
Anomalous Dopamine Release Associated with a Human Dopamine Transporter Coding Variant.
Published in:
Journal of Neuroscience, 2008, v. 28, n. 28, p. 7040, doi. 10.1523/JNEUROSCI.0473-08.2008
By:
- Mazei-Robison, Michelle S.;
- Bowton, Erica;
- Holy, Marion;
- Schmudermaier, Martin;
- Freissmuth, Michael;
- Sitte, Harald H.;
- Galli, Aurelio;
- Blakely, Randy D.
Publication type:
Article
A Novel and Selective Dopamine Transporter Inhibitor, (S) -MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions.
Published in:
Biomolecules (2218-273X), 2022, v. 12, n. 7, p. N.PAG, doi. 10.3390/biom12070881
By:
- Kouhnavardi, Shima;
- Ecevitoglu, Alev;
- Dragačević, Vladimir;
- Sanna, Fabrizio;
- Arias-Sandoval, Edgar;
- Kalaba, Predrag;
- Kirchhofer, Michael;
- Lubec, Jana;
- Niello, Marco;
- Holy, Marion;
- Zehl, Martin;
- Pillwein, Matthias;
- Wackerlig, Judith;
- Murau, Rita;
- Mohrmann, Andrea;
- Beard, Kathryn R.;
- Sitte, Harald H.;
- Urban, Ernst;
- Sagheddu, Claudia;
- Pistis, Marco
Publication type:
Article
Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.
Published in:
PLoS Neglected Tropical Diseases, 2018, v. 12, n. 4, p. 1, doi. 10.1371/journal.pntd.0006428
By:
- Hamali, Bulut;
- Pichler, Sandra;
- Wischnitzki, Elisabeth;
- Schicker, Klaus;
- Burger, Melanie;
- Holy, Marion;
- Jaentsch, Kathrin;
- Molin, Martina;
- Sehr, Eva Maria;
- Kudlacek, Oliver;
- Freissmuth, Michael
Publication type:
Article
The synthetic cathinones, butylone and pentylone, are stimulants that act as dopamine transporter blockers but 5-HT transporter substrates.
Published in:
Psychopharmacology, 2019, v. 236, n. 3, p. 953, doi. 10.1007/s00213-018-5075-5
By:
- Saha, Kusumika;
- Li, Yang;
- Holy, Marion;
- Lehner, Kurt R.;
- Bukhari, Mohammad O.;
- Partilla, John S.;
- Sandtner, Walter;
- Sitte, Harald H.;
- Baumann, Michael H.
Publication type:
Article
Structural basis of organic cation transporter-3 inhibition.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34284-8
By:
- Khanppnavar, Basavraj;
- Maier, Julian;
- Herborg, Freja;
- Gradisch, Ralph;
- Lazzarin, Erika;
- Luethi, Dino;
- Yang, Jae-Won;
- Qi, Chao;
- Holy, Marion;
- Jäntsch, Kathrin;
- Kudlacek, Oliver;
- Schicker, Klaus;
- Werge, Thomas;
- Gether, Ulrik;
- Stockner, Thomas;
- Korkhov, Volodymyr M.;
- Sitte, Harald H.
Publication type:
Article
Structural basis of organic cation transporter-3 inhibition.
Published in:
Nature Communications, 2022, v. 13, p. 1, doi. 10.1038/s41467-022-34284-8
By:
- Khanppnavar, Basavraj;
- Maier, Julian;
- Herborg, Freja;
- Gradisch, Ralph;
- Lazzarin, Erika;
- Luethi, Dino;
- Yang, Jae-Won;
- Qi, Chao;
- Holy, Marion;
- Jäntsch, Kathrin;
- Kudlacek, Oliver;
- Schicker, Klaus;
- Werge, Thomas;
- Gether, Ulrik;
- Stockner, Thomas;
- Korkhov, Volodymyr M.;
- Sitte, Harald H.
Publication type:
Article
Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2008, v. 378, n. 3, p. 323, doi. 10.1007/s00210-008-0293-8
By:
- Steiner, Ilka;
- Errhalt, Peter;
- Kubesch, Klaus;
- Hubner, Marianne;
- Holy, Marion;
- Bauer, Martin;
- Müller, Markus;
- Hinterberger, Sabine;
- Widmann, Rudolf;
- Mascher, Daniel;
- Freissmuth, Michael;
- Kneussl, Meinhard
Publication type:
Article
'Second-Generation' Mephedrone Analogs, 4-MEC and 4-MePPP, Differentially Affect Monoamine Transporter Function.
Published in:
Neuropsychopharmacology, 2015, v. 40, n. 6, p. 1321, doi. 10.1038/npp.2014.325
By:
- Saha, Kusumika;
- Partilla, John S;
- Lehner, Kurt R;
- Seddik, Amir;
- Stockner, Thomas;
- Holy, Marion;
- Sandtner, Walter;
- Ecker, Gerhard F;
- Sitte, Harald H;
- Baumann, Michael H
Publication type:
Article
Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive 'Bath Salts' Products.
Published in:
Neuropsychopharmacology, 2013, v. 38, n. 4, p. 552, doi. 10.1038/npp.2012.204
By:
- Baumann, Michael H;
- Partilla, John S;
- Lehner, Kurt R;
- Thorndike, Eric B;
- Hoffman, Alexander F;
- Holy, Marion;
- Rothman, Richard B;
- Goldberg, Steven R;
- Lupica, Carl R;
- Sitte, Harald H;
- Brandt, Simon D;
- Tella, Srihari R;
- Cozzi, Nicholas V;
- Schindler, Charles W
Publication type:
Article
Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2023, v. 133, n. 5, p. 535, doi. 10.1111/bcpt.13940
By:
- Brugnoli, Francesca R.;
- Holy, Marion;
- Niello, Marco;
- Maier, Julian;
- Hanreich, Marcus;
- Menzel, Mario;
- Haberler, Matthias;
- Zulus, Niklas;
- Pickl, Thomas;
- Ivanova, Christa;
- Muiznieks, Lisa D.;
- Garlan, Benjamin;
- Sitte, Harald H.
Publication type:
Article
Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2020.00673
By:
- Ilic, Marija;
- Maier, Julian;
- Holy, Marion;
- Jaentsch, Kathrin;
- Liechti, Matthias E.;
- Lubec, Gert;
- Baumann, Michael H.;
- Sitte, Harald H.;
- Luethi, Dino
Publication type:
Article
Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.749429
By:
- Nadal-Gratacós, Nuria;
- Alberto-Silva, Ana Sofia;
- Rodríguez-Soler, Míriam;
- Urquizu, Edurne;
- Espinosa-Velasco, Maria;
- Jäntsch, Kathrin;
- Holy, Marion;
- Batllori, Xavier;
- Berzosa, Xavier;
- Pubill, David;
- Camarasa, Jordi;
- Sitte, Harald H.;
- Escubedo, Elena;
- López-Arnau, Raúl
Publication type:
Article
Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro.
Published in:
Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.654061
By:
- Niello, Marco;
- Cintulová, Daniela;
- Raithmayr, Philip;
- Holy, Marion;
- Jäntsch, Kathrin;
- Colas, Claire;
- Ecker, Gerhard F.;
- Sitte, Harald H.;
- Mihovilovic, Marko D.
Publication type:
Article
Amphetamine actions rely on the availability of phosphatidylinositol-4,5-bisphosphate.
Published in:
2011
By:
- Buchmayer, Florian;
- Schicker, Klaus;
- Stübiger, Gerald;
- Hamilton, Peter J;
- Geier, Petra;
- Jurik, Andreas;
- Weissensteiner, René;
- Steinkellner, Thomas;
- Matthies, Heinrich J;
- Montgomery, Therese;
- Winkler, Marie-Therese;
- Yang, Jae-Won;
- Holy, Marion;
- Ecker, Gerhard F;
- Galli, Aurelio;
- Bochkov, Valery;
- Boehm, Stefan;
- Sitte, Harald H
Publication type:
Abstract
Selective serotonin reuptake inhibitors: a new modality for the treatment of lymphoma/leukaemia?
Published in:
BMC Pharmacology, 2007, v. 7, p. 1, doi. 10.1186/1471-2210-7-S2-A8
By:
- Schuster, Christian;
- Fernbach, Nora;
- Rix, Uwe;
- Superti-Furga, Giulio;
- Holy, Marion;
- Freissmuth, Michael;
- Sitte, Harald H.;
- Sexl, Veronika
Publication type:
Article
Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.
Published in:
Molecular Informatics, 2017, v. 36, n. 5/6, p. n/a, doi. 10.1002/minf.201600094
By:
- Seddik, Amir;
- Geerke, Daan P.;
- Stockner, Thomas;
- Holy, Marion;
- Kudlacek, Oliver;
- Cozzi, Nicholas V.;
- Ruoho, Arnold E.;
- Sitte, Harald H.;
- Ecker, Gerhard F.
Publication type:
Article
Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.
Published in:
Angewandte Chemie, 2016, v. 128, n. 5, p. 1751, doi. 10.1002/ange.201508755
By:
- Zhu, Rong;
- Sinwel, Doris;
- Hasenhuetl, Peter S.;
- Saha, Kusumika;
- Kumar, Vivek;
- Zhang, Peng;
- Rankl, Christian;
- Holy, Marion;
- Sucic, Sonja;
- Kudlacek, Oliver;
- Karner, Andreas;
- Sandtner, Walter;
- Stockner, Thomas;
- Gruber, Hermann J.;
- Freissmuth, Michael;
- Newman, Amy Hauck;
- Sitte, Harald H.;
- Hinterdorfer, Peter
Publication type:
Article
Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling.
Published in:
Molecular Informatics, 2013, v. 32, n. 5/6, p. 409, doi. 10.1002/minf.201300013
By:
- Seddik, Amir;
- Holy, Marion;
- Weissensteiner, René;
- Zdrazil, Barbara;
- Sitte, Harald H.;
- Ecker, Gerhard F.
Publication type:
Article
<sup>68</sup>Ga‐Labelled Tropane Analogues for the Visualization of the Dopaminergic System.
Published in:
ChemMedChem, 2021, v. 16, n. 5, p. 804, doi. 10.1002/cmdc.202000820
By:
- Häseli, Sascha;
- Holy, Marion;
- Joksch, Markus;
- Bergner, Carina;
- Wree, Andreas;
- Kurth, Jens;
- Cankaya, Aylin;
- Piel, Markus;
- Krause, Bernd J.;
- Sitte, Harald H.;
- Rösch, Frank
Publication type:
Article
Ethanol Inhibits Dopamine Uptake and Augments Rewarding Effects of Cocaine via Organic Cation Transporter 3.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R5274
By:
- Clauss, Nikki J.;
- Owens, W. A.;
- Vitela, Melissa;
- Bowman, Melodi A.;
- Mayer, Felix P.;
- Schmid, Diethart;
- Holy, Marion;
- Sitte, Harrold H.;
- Gould, Geogianna G.;
- Koek, Wouter;
- Daws, Lynette C.
Publication type:
Article
N, N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents.
Published in:
Journal of Neurochemistry, 2008, v. 105, n. 5, p. 1770, doi. 10.1111/j.1471-4159.2008.05272.x
By:
- Gobbi, Marco;
- Funicello, Marcella;
- Gerstbrein, Klaus;
- Holy, Marion;
- Moya, Pablo R.;
- Sotomayor, Ramón;
- Forray, María Inés;
- Gysling, Katia;
- Paluzzi, Silvio;
- Bonanno, Giambattista;
- Reyes-Parada, Miguel;
- Sitte, Harald H.;
- Mennini, Tiziana
Publication type:
Article
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 7, p. 3107, doi. 10.1172/JCI73778
By:
- Hansen, Freja H.;
- Skjørringe, Tina;
- Yasmeen, Saiqa;
- Arends, Natascha V.;
- Sahai, Michelle A.;
- Erreger, Kevin;
- Andreassen, Thorvald F.;
- Holy, Marion;
- Hamilton, Peter J.;
- Neergheen, Viruna;
- Karlsborg, Merete;
- Newman, Amy H.;
- Pope, Simon;
- Heales, Simon J. R.;
- Friberg, Lars;
- Law, Ian;
- Pinborg, Lars H.;
- Sitte, Harald H.;
- Loland, Claus;
- Lei Shi
Publication type:
Article
Phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) facilitates norepinephrine transporter dimerization and modulates substrate efflux.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04210-1
By:
- Luethi, Dino;
- Maier, Julian;
- Rudin, Deborah;
- Szöllősi, Dániel;
- Angenoorth, Thomas J. F.;
- Stankovic, Stevan;
- Schittmayer, Matthias;
- Burger, Isabella;
- Yang, Jae-Won;
- Jaentsch, Kathrin;
- Holy, Marion;
- Das, Anand Kant;
- Brameshuber, Mario;
- Camacho-Hernandez, Gisela Andrea;
- Casiraghi, Andrea;
- Newman, Amy Hauck;
- Kudlacek, Oliver;
- Birner-Gruenberger, Ruth;
- Stockner, Thomas;
- Schütz, Gerhard J.
Publication type:
Article
Cell-Based Radiotracer Binding and Uptake Inhibition Assays: A Comparison of In Vitro Methods to Assess the Potency of Drugs That Target Monoamine Transporters.
Published in:
Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00673
By:
- Ilic, Marija;
- Holy, Marion;
- Jaentsch, Kathrin;
- Liechti, Matthias E.;
- Lubec, Gert;
- Baumann, Michael H.;
- Sitte, Harald H.;
- Luethi, Dino
Publication type:
Article
A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System.
Published in:
Frontiers in Behavioral Neuroscience, 2016, p. 1, doi. 10.3389/fnbeh.2016.000
By:
- Aher, Yogesh D.;
- Subramaniyan, Saraswathi;
- Shanmugasundaram, Bharanidharan;
- Sase, Ajinkya;
- Saroja, Sivaprakasam R.;
- Holy, Marion;
- Höger, Harald;
- Beryozkina, Tetyana;
- Sitte, Harald H.;
- Leban, Johann J.;
- Lubec, Gert
Publication type:
Article
Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 12995, doi. 10.3390/ijms222312995
By:
- Angenoorth, Thomas J. F.;
- Stankovic, Stevan;
- Niello, Marco;
- Holy, Marion;
- Brandt, Simon D.;
- Sitte, Harald H.;
- Maier, Julian
Publication type:
Article

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