Results
Title

S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells.

Authors

Mosca, Laura; Pagano, Martina; Pecoraro, Annalisa; Borzacchiello, Luigi; Mele, Luigi; Cacciapuoti, Giovanna; Porcelli, Marina; Russo, Giulia; Russo, Annapina

Abstract

Purpose: In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53. Results: In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. In particular, we demonstrated that S-adenosyl-l-methionine causes cell cycle arrest at the S phase; inhibits autophagy; augments reactive oxygen species; and induces apoptosis in these cancer cells. Conclusions: Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes.

Subjects

DRUG resistance in cancer cells; DRUG resistance; CANCER cells; COLON cancer; CELL cycle; P53 antioncogene

Publication

International Journal of Molecular Sciences, 2021, Vol 22, Issue 1, p103

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms22010103