Results
Title

MYC in Brain Development and Cancer.

Authors

Zaytseva, Olga; Kim, Nan-hee; Quinn, Leonie M.

Abstract

The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC's capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC's roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.

Subjects

NEURAL development; BRAIN tumors; NEURAL stem cells; ANIMAL development; NERVOUS system

Publication

International Journal of Molecular Sciences, 2020, Vol 21, Issue 20, p7742

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms21207742