Results
Title

Regulation of Hematopoietic Stem Cell Fate and Malignancy.

Authors

Cho, Hee Jun; Lee, Jungwoon; Yoon, Suk Ran; Lee, Hee Gu; Jung, Haiyoung

Abstract

The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one's lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. In this review, we focus on the current understanding of signaling pathways that regulate HSC fate including quiescence, self-renewal, and differentiation during aging, and additionally introduce pharmacological approaches to rescue defects of HSC fate determination or hematopoietic malignancies by kinase signaling pathways.

Subjects

HEMATOPOIETIC stem cells; HEMATOLOGIC malignancies; BLOOD cells

Publication

International Journal of Molecular Sciences, 2020, Vol 21, Issue 13, p4780

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms21134780