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- Title
Regulation of Hematopoietic Stem Cell Fate and Malignancy.
- Authors
Cho, Hee Jun; Lee, Jungwoon; Yoon, Suk Ran; Lee, Hee Gu; Jung, Haiyoung
- Abstract
The regulation of hematopoietic stem cell (HSC) fate decision, whether they keep quiescence, self-renew, or differentiate into blood lineage cells, is critical for maintaining the immune system throughout one's lifetime. As HSCs are exposed to age-related stress, they gradually lose their self-renewal and regenerative capacity. Recently, many reports have implicated signaling pathways in the regulation of HSC fate determination and malignancies under aging stress or pathophysiological conditions. In this review, we focus on the current understanding of signaling pathways that regulate HSC fate including quiescence, self-renewal, and differentiation during aging, and additionally introduce pharmacological approaches to rescue defects of HSC fate determination or hematopoietic malignancies by kinase signaling pathways.
- Subjects
HEMATOPOIETIC stem cells; HEMATOLOGIC malignancies; BLOOD cells
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 13, p4780
- ISSN
1661-6596
- Publication type
Academic Journal
- DOI
10.3390/ijms21134780