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- Title
Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences.
- Authors
So-hyeon Hong; Kyung Mook Choi
- Abstract
The prevalence of sarcopenic obesity is increasing worldwide, particularly amongst aging populations. Insulin resistance is the core mechanism of sarcopenic obesity and is also associated with variable cardiometabolic diseases such as cardiovascular disease, type 2 diabetes mellitus, and non-alcoholic fatty liver disease. Fat accumulation in muscle tissue promotes a proinflammatory cascade and oxidative stress, leading to mitochondrial dysfunction, impaired insulin signaling, and muscle atrophy. To compound the problem, decreased muscle mass aggravates insulin resistance. In addition, the crosstalk between myokines and adipokines leads to negative feedback, which in turn aggravates sarcopenic obesity and insulin resistance. In this review, we focus on the molecular mechanisms linking sarcopenic obesity and insulin resistance with various biological pathways. We also discuss the impact and mechanism of sarcopenic obesity and insulin resistance on cardiometabolic disease.
- Subjects
INSULIN resistance; TYPE 2 diabetes; FATTY liver; ADIPOKINES; OBESITY; INSULIN; HEART metabolism disorders
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 2, p1
- ISSN
1661-6596
- Publication type
Review
- DOI
10.3390/ijms21020494