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Title

Causes and Mechanisms of Hematopoietic Stem Cell Aging.

Authors

Lee, Jungwoon; Jung, Haiyoung; Yoon, Suk Ran; Choi, Inpyo

Abstract

Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells throughout the lifetime of an organism. Recent reports have suggested that HSCs are susceptible to age-related stress and gradually lose their self-renewal and regeneration capacity with aging. HSC aging is driven by cell-intrinsic and -extrinsic factors that result in the disruption of the immune system. Thus, the study of HSC aging is important to our understanding of age-related immune diseases and can also provide potential strategies to improve quality of life in the elderly. In this review, we delineate our understanding of the phenotypes, causes, and molecular mechanisms involved in HSC aging.

Subjects

OLDER people; BLOOD diseases; HEMATOPOIETIC stem cells; IMMUNE system; BLOOD cells; PHENOTYPES

Publication

International Journal of Molecular Sciences, 2019, Vol 20, Issue 6, p1272

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms20061272