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Title

Histone Lysine Methylation and Neurodevelopmental Disorders.

Authors

Jeong-Hoon Kim; Jang Ho Lee; Im-Soon Lee; Sung Bae Lee; Kyoung Sang Cho

Abstract

Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases.

Subjects

HISTONE demethylases; ESSENTIAL amino acids; HIGH-lysine diet; EPIGENETICS; LYSINE derivatives

Publication

International Journal of Molecular Sciences, 2017, Vol 18, Issue 7, p1404

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms18071404