We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases.
- Authors
Tae Woo Jung; Kyung Mook Choi
- Abstract
The endoplasmic reticulum (ER) is the principal organelle responsible for correct protein folding, a step in protein synthesis that is critical for the functional conformation of proteins. ER stress is a primary feature of secretory cells and is involved in the pathogenesis of numerous human diseases, such as certain neurodegenerative and cardiometabolic disorders. The unfolded protein response (UPR) is a defense mechanism to attenuate ER stress and maintain the homeostasis of the organism. Two major degradation systems, including the proteasome and autophagy, are involved in this defense system. If ER stress overwhelms the capacity of the cell's defense mechanisms, apoptotic death may result. This review is focused on the various pharmacological modulators that can protect cells from damage induced by ER stress. The possible mechanisms for cytoprotection are also discussed.
- Subjects
PHARMACOLOGY; ENDOPLASMIC reticulum; PROTEIN synthesis; SECRETION; HOMEOSTASIS; PROTEASOMES
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 2, p192
- ISSN
1661-6596
- Publication type
Academic Journal
- DOI
10.3390/ijms17020192