Results
Title

Potential Effects of Chrysin on MDA-MB-231 Cells.

Authors

Teh Ban Hong; Rahumatullah, Anizah; Yogarajah, Thaneswary; Ahmad, Maimunah; Khoo Boon Yin

Abstract

This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 μM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.

Subjects

GROWTH factors; BREAST cancer; CYTOPLASM; LIPIDS; APOPTOSIS; CELL death; CELL proliferation; PHYTOCHEMICALS; OXIDATION

Publication

International Journal of Molecular Sciences, 2010, Vol 11, Issue 3, p1057

ISSN

1661-6596

Publication type

Academic Journal

DOI

10.3390/ijms11031057