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- Title
Potential Effects of Chrysin on MDA-MB-231 Cells.
- Authors
Teh Ban Hong; Rahumatullah, Anizah; Yogarajah, Thaneswary; Ahmad, Maimunah; Khoo Boon Yin
- Abstract
This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 μM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
- Subjects
GROWTH factors; BREAST cancer; CYTOPLASM; LIPIDS; APOPTOSIS; CELL death; CELL proliferation; PHYTOCHEMICALS; OXIDATION
- Publication
International Journal of Molecular Sciences, 2010, Vol 11, Issue 3, p1057
- ISSN
1661-6596
- Publication type
Academic Journal
- DOI
10.3390/ijms11031057