Long COVID among Brazilian Adults and Elders 12 Months after Hospital Discharge: A Population-Based Cohort Study.

Salci, Maria Aparecida; Carreira, Lígia; Oliveira, Natan Nascimento; Pereira, Natan David; Covre, Eduardo Rocha; Pesce, Giovanna Brichi; Oliveira, Rosana Rosseto; Höring, Carla Franciele; Baccon, Wanessa Cristina; Puente Alcaraz, Jesús; Santos, Giovana Alves; Bolsoni, Ludmila Lopes Maciel; Gutiérrez Carmona, Andrés; Vissoci, João Ricardo Nickenig; Facchini, Luiz Augusto; Laranjeira, Carlos

The persistence of symptoms for more than three months following infection with severe acute respiratory syndrome coronavirus 2 is referred to as "Long COVID". To gain a deeper understanding of the etiology and long-term progression of symptoms, this study aims to analyze the prevalence of Long COVID and its associated factors in a cohort of Brazilian adults and elders, twelve months after hospital discharge. An observational, prospective, and follow-up study was performed with a cohort of adults and older adults diagnosed with COVID-19 in 2020 in the State of Paraná, Brazil. Twelve months after hospital discharge, patients answered a phone questionnaire about the persistence of symptoms after three levels of exposure to COVID-19's acute phase (ambulatory, medical ward, and intensive care unit). According to the characteristics of participants, the prevalence of Long COVID-19 was calculated, and logistic regression analyses were conducted. We analyzed data from 1822 participants (980 adults [≥18–<60 years] and 842 older people [≥60 years]) across three exposure levels. The overall Long COVID prevalence was 64.2%. Long COVID was observed in 646 adults (55%; of which 326 were women) and 523 older people (45%; of which 284 were women). Females had a higher prevalence of long-term symptoms (52%) compared with men. The most common post-COVID-19 conditions in the 12-month follow-up were neurological (49.8%), followed by musculoskeletal (35.1%) and persistent respiratory symptoms (26.5%). Male individuals were less likely to develop Long COVID (aOR = 0.50). Other determinants were also considered risky, such as the presence of comorbidities (aOR = 1.41). Being an adult and having been hospitalized was associated with the development of Long COVID. The risk of developing Long COVID was twice as high for ward patients (aOR = 2.53) and three times as high for ICU patients (aOR = 3.56) when compared to non-hospitalized patients. Presenting clinical manifestations of digestive (aOR = 1.56), endocrine (aOR = 2.14), cutaneous (aOR = 2.51), musculoskeletal (aOR = 2.76) and psychological systems (aOR = 1.66) made adults more likely to develop Long COVID. Long COVID was present in a large proportion of people affected by the SARS-CoV-2 infection. Presence of Long COVID symptoms displayed a dose–response relationship with the level of disease exposure, with a greater prevalence of symptoms associated with the severe form in the acute period.

BRAZIL; RESEARCH funding; POST-acute COVID-19 syndrome; SCIENTIFIC observation; QUESTIONNAIRES; OUTPATIENT medical care; LOGISTIC regression analysis; HOSPITAL care; DISCHARGE planning; DESCRIPTIVE statistics; RELATIVE medical risk; MULTIVARIATE analysis; LONGITUDINAL method; ODDS ratio; TELEPHONES; INTENSIVE care units; RESEARCH methodology; COMPARATIVE studies; DATA analysis software; CONFIDENCE intervals; SOCIODEMOGRAPHIC factors; DISEASE progression; PATIENT aftercare; COMORBIDITY; SYMPTOMS; ADULTS; OLD age

Healthcare (2227-9032), 2024, Vol 12, Issue 14, p1443

2227-9032

Academic Journal

10.3390/healthcare12141443