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- Title
A Photo-Enzymatic Cascade to Transform Racemic Alcohols into Enantiomerically Pure Amines.
- Authors
Gacs, Jenő; Zhang, Wuyuan; Knaus, Tanja; Mutti, Francesco G.; Arends, Isabel W.C.E.; Hollmann, Frank
- Abstract
The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω-transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade.
- Subjects
ENANTIOMERIC purity; ALIPHATIC compounds; AMINES; ALCOHOL; KETONES
- Publication
Catalysts (2073-4344), 2019, Vol 9, Issue 4, p305
- ISSN
2073-4344
- Publication type
Academic Journal
- DOI
10.3390/catal9040305