Compared with the traditional granular catalyst, a mesh-type structured CuZn-based catalyst prepared by the self-growth ordered nanoporous carrier γ-Al2O3/Al can adapt to the MSR reaction system with high flux, strong mass transfer and heat transfer, and can promote the practical process. In this study, the kinetic experiment using a CuZn-based structured catalyst was carried out, and a nonlinear single-rate PL model was established. Based on this, a 3D theoretical model of the MSR reformer was drawn in COMSOL Multiphysics. By changing the stacking form and mesh shape of the catalyst to construct the flow channel, the chemical reaction process, heat transfer process, and mass transfer process of the CuZn structured catalyst in the reformer under different flow channels are further simulated, which provides a theoretical basis for studying the enhancement of the MSR reaction and the development of a supporting micro hydrogen production system.