Works matching AU Lesyk, Roman

Results: 102

Synthesis of potential antiviral agents among chromeno[4',3':4,5]thiopyrano[2,3-d][1,3]thiazole-5-carboxylates.

Published in:

Ukrainian Biochemical Journal, 2016, v. 88, p. 76

By:

Zelisko, Nataliya;
Lesyk, Roman

Publication type:

Article

Putative anticancer potential of novel 4-thiazolidinone derivatives: toxicity towards rat C6 glioma cells and correlation of general toxicity with balance of free radical oxidation in rats.

Published in:

Ukrainian Biochemical Journal, 2016, v. 88, p. 59

By:

Коbylinska, Lesya;
Panchuk, Rostyslav;
Boiko, Nataliya;
Grytsyna, Iryna;
Klyuchivska, Olga;
Biletska, Liliya;
Lesyk, Roman;
Zimenkovsky, Borys;
Stoika, Rostyslav

Publication type:

Article

Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 2, p. 26, doi. 10.3390/scipharm91020026

By:

Demchenko, Sergii;
Lesyk, Roman;
Yadlovskyi, Oleh;
Holota, Serhii;
Yarmoluk, Sergii;
Tsyhankov, Sergii;
Demchenko, Anatolii

Publication type:

Article

3-[5-(1 H -Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 1, p. 13, doi. 10.3390/scipharm91010013

By:

Konechnyi, Yulian;
Lozynskyi, Andrii;
Ivasechko, Iryna;
Dumych, Tetiana;
Paryzhak, Solomiya;
Hrushka, Oksana;
Partyka, Ulyana;
Pasichnyuk, Iryna;
Khylyuk, Dmytro;
Lesyk, Roman

Publication type:

Article

Detailing the Ten Main Professional Roles of a Pharmacist to Provide the Scope of Professional Functions.

Published in:

Scientia Pharmaceutica, 2023, v. 91, n. 1, p. 5, doi. 10.3390/scipharm91010005

By:

Kremin, Yuliia;
Lesyk, Lilia;
Lesyk, Roman;
Levytska, Oksana;
Hromovyk, Bohdan

Publication type:

Article

Evaluation of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent.

Published in:

Scientia Pharmaceutica, 2022, v. 90, n. 3, p. 56, doi. 10.3390/scipharm90030056

By:

Mishchenko, Mariia;
Shtrygol', Sergiy;
Lozynskyi, Andrii;
Hoidyk, Mykhailo;
Khyluk, Dmytro;
Gorbach, Tatyana;
Lesyk, Roman

Publication type:

Article

Compounding in Ukraine: Assessment of the Risks for the Ointment's Quality by the FMECA Method.

Published in:

Scientia Pharmaceutica, 2022, v. 90, n. 2, p. N.PAG, doi. 10.3390/scipharm90020025

By:

Savchenko, Lesia;
Pidpruzhnykov, Yuri;
Lesyk, Roman;
Ivanauskas, Liudas;
Kotvitska, Alla;
Georgiyants, Victoriya

Publication type:

Article

Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 4, p. 1, doi. 10.3390/scipharm89040052

By:

Lozynskyi, Andrii;
Konechnyi, Yulian;
Senkiv, Julia;
Yushyn, Ihor;
Khyluk, Dmytro;
Karpenko, Olexandr;
Shepeta, Yulia;
Lesyk, Roman

Publication type:

Article

Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 2, p. 1, doi. 10.3390/scipharm89020028

By:

Mykhailenko, Olha;
Ivanauskas, Liudas;
Bezruk, Ivan;
Sidorenko, Lyudmila;
Lesyk, Roman;
Georgiyants, Victoriya

Publication type:

Article

Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues.

Published in:

Scientia Pharmaceutica, 2021, v. 89, n. 2, p. 1, doi. 10.3390/scipharm89020022

By:

Mishchenko, Mariia;
Shtrygol, Sergiy;
Lozynskyi, Andrii;
Khomyak, Semen;
Novikov, Volodymyr;
Karpenko, Olexandr;
Holota, Serhii;
Lesyk, Roman

Publication type:

Article

Biodistribution and Anticancer Characteristics of Les-3833, A Novel 4-thiazolidinone-Based Lead Compound.

Published in:

Scientia Pharmaceutica, 2020, v. 88, n. 2, p. 1, doi. 10.3390/scipharm88020018

By:

Kobylinska, Lesya;
Lozynskii, Andrii;
Lesyk, Roman;
Stoika, Rostyslav;
Vari, Sandor G.

Publication type:

Article

Isothiochromenothiazoles--A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei.

Published in:

Scientia Pharmaceutica, 2018, v. 86, n. 4, p. 1, doi. 10.3390/scipharm86040047

By:

Kryshchyshyn, Anna;
Kaminskyy, Danylo;
Nektegayev, Igor;
Grellier, Philippe;
Lesyk, Roman

Publication type:

Article

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy.

Published in:

Scientia Pharmaceutica, 2017, v. 85, n. 4, p. 1, doi. 10.3390/scipharm85040035

By:

Sklyarova, Yulia;
Fomenko, Iryna;
Lozynska, Iryna;
Lozynskyi, Andrii;
Lesyk, Roman;
Sklyarov, Alexandr

Publication type:

Article

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.

Published in:

Scientia Pharmaceutica, 2018, v. 86, n. 2, p. 1, doi. 10.3390/scipharm86020026

By:

Kryshchyshyn, Anna;
Roman, Olexandra;
Lozynskyi, Andrii;
Lesyk, Roman

Publication type:

Article

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides.

Published in:

Scientia Pharmaceutica, 2014, v. 82, n. 4, p. 723, doi. 10.3797/scipharm.1408-05

By:

LOZYNSKYI, Andrii;
ZIMENKOVSKY, Borys;
LESYK, Roman

Publication type:

Article

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides.

Published in:

Scientia Pharmaceutica, 2014, v. 82, n. 4, p. 723, doi. 10.3797/scipharm.1408-05

By:

LOZYNSKYI, Andrii;
ZIMENKOVSKY, Borys;
LESYK, Roman

Publication type:

Article

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety.

Published in:

Scientia Pharmaceutica, 2013, v. 81, n. 2, p. 423, doi. 10.3797/scipharm.1301-13

By:

ATAMANYUK, Dmytro;
ZIMENKOVSKY, Borys;
ATAMANYUK, Vasyl;
NEKTEGAYEV, Ihor;
LESYK, Roman

Publication type:

Article

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents.

Published in:

Scientia Pharmaceutica, 2012, v. 80, n. 3, p. 509, doi. 10.3797/scipharm.1204-02

By:

Kryshchyshyn, Anna;
Atamanyuk, Dmytro;
Lesyk, Roman

Publication type:

Article

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates.

Published in:

Scientia Pharmaceutica, 2011, v. 79, n. 4, p. 763, doi. 10.3797/scipharm.1109-14

By:

Kaminskyy, Danylo;
Khyluk, Dmytro;
Vasylenko, Olexandr;
Zaprutko, Lucjusz;
Lesyk, Roman

Publication type:

Article

5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3- d ][1,3]thiazole Core.

Published in:

Synthetic Communications, 2014, v. 44, n. 2, p. 237, doi. 10.1080/00397911.2013.800552

By:

Atamanyuk, Dmytro;
Zimenkovsky, Borys;
Atamanyuk, Vasyl;
Lesyk, Roman

Publication type:

Article

Cyclocondensation of Thioamides and Haloacetic Acid Derivatives Provides Only 4-Thiazolidinones; Isomeric 5-Thiazolidinones Were Not observed.

Published in:

Synthetic Communications, 2014, v. 44, n. 2, p. 231, doi. 10.1080/00397911.2013.800551

By:

Kaminskyy, Danylo;
Gzella, AndrzejK.;
Lesyk, Roman

Publication type:

Article

Manganic encephalopathy due to "ephedrone" abuse.

Published in:

2007

By:

Sanotsky, Yanush;
Lesyk, Roman;
Fedoryshyn, Lyudmyla;
Komnatska, Iryna;
Matviyenko, Yuriy;
Fahn, Stanley

Publication type:

journal article

Human Healthcare and Its Pharmacy Component from a Safety Point of View.

Published in:

Pharmacy, 2024, v. 12, n. 2, p. 64, doi. 10.3390/pharmacy12020064

By:

Tkachenko, Natalia;
Pankevych, Ostap;
Mahanova, Tamara;
Hromovyk, Bohdan;
Lesyk, Roman;
Lesyk, Lilia

Publication type:

Article

A New 4-Thiazolidinone Derivative (Les-6490) as a Gut Microbiota Modulator: Antimicrobial and Prebiotic Perspectives.

Published in:

Antibiotics (2079-6382), 2024, v. 13, n. 4, p. 291, doi. 10.3390/antibiotics13040291

By:

Konechnyi, Yulian;
Rumynska, Tetyana;
Yushyn, Ihor;
Holota, Serhii;
Turkina, Vira;
Ryviuk Rydel, Mariana;
Sękowska, Alicja;
Salyha, Yuriy;
Korniychuk, Olena;
Lesyk, Roman

Publication type:

Article

Proton tautomerism and stereoisomerism in 5‐[(dimethylamino)methylidene]‐4‐[3/4‐(trifluoromethylphenyl)amino]‐1,3‐thiazol‐2(5H)‐ones: synthesis, crystal structure and spectroscopic studies.

Published in:

Acta Crystallographica Section C: Structural Chemistry, 2023, v. 79, n. 11, p. 480, doi. 10.1107/S2053229623009087

By:

Pyrih, Andrii;
Łapiński, Andrzej;
Zięba, Sylwia;
Mizera, Adam;
Lesyk, Roman;
Gzella, Andrzej K.;
Jaskolski, Mariusz

Publication type:

Article

Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives.

Published in:

Acta Crystallographica Section C: Structural Chemistry, 2014, v. 70, n. 8, p. 812, doi. 10.1107/S2053229614015162

By:

Gzella, Andrzej K.;
Kowiel, Marcin;
Suseł, Aneta;
Wojtyra, Magdalena N.;
Lesyk, Roman

Publication type:

Article

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells.

Published in:

Croatian Medical Journal, 2017, v. 58, n. 2, p. 150, doi. 10.3325/cmj.2017.58.150

By:

Kobylinska, Lesya I.;
Klyuchivska, Olga Yu.;
Grytsyna, Iryna I.;
Finiuk, Natalia;
Panchuk, Rostyslav R.;
Starykovych, Marina O.;
Lehka, Lilya;
Lesyk, Roman B.;
Zimenkovsky, Borys S.;
Stoika, Rostyslav S.

Publication type:

Article

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms.

Published in:

Croatian Medical Journal, 2017, v. 58, n. 2, p. 129, doi. 10.3325/cmj.2017.58.129

By:

Finiuk, Nataliya;
Boiko, Nataliya;
Klyuchivska, Olga;
Kobylinska, Lesya;
Kril, Iryna;
Zimenkovsky, Borys;
Lesyk, Roman;
Stoika, Rostyslav

Publication type:

Article

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats.

Published in:

Croatian Medical Journal, 2016, v. 57, n. 2, p. 151, doi. 10.3325/cmj.2016.57.151

By:

Kobylinska, Lesya I.;
Boiko, Nataliya M.;
Panchuk, Rostyslav R.;
Grytsyna, Iryna I.;
Klyuchivska, Olga Yu.;
Biletska, Liliya P.;
Lesyk, Roman B.;
Zimenkovsky, Borys S.;
Stoika, Rostyslav S.

Publication type:

Article

Changes in Energy Consumption, Economic Growth and Aspirations for Energy Independence: Sectoral Analysis of Uses of Natural Gas in Ukrainian Economy.

Published in:

Energies (19961073), 2019, v. 12, n. 24, p. 4724, doi. 10.3390/en12244724

By:

Yemelyanov, Olexandr;
Symak, Anastasiya;
Petrushka, Tetyana;
Zahoretska, Olena;
Kusiy, Myroslava;
Lesyk, Roman;
Lesyk, Lilia

Publication type:

Article

Evaluation of the Adaptability of the Ukrainian Economy to Changes in Prices for Energy Carriers and to Energy Market Risks.

Published in:

Energies (19961073), 2018, v. 11, n. 12, p. 3529, doi. 10.3390/en11123529

By:

Yemelyanov, Olexandr;
Symak, Anastasiya;
Petrushka, Tetyana;
Lesyk, Roman;
Lesyk, Lilia

Publication type:

Article

PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production.

Published in:

International Journal of Nanomedicine, 2024, v. 19, p. 14021, doi. 10.2147/IJN.S479137

By:

Tulinska, Jana;
Kobylinska, Lesya;
Mikusova, Miroslava Lehotska;
Babincova, Julia;
Mitina, Natalia;
Rollerova, Eva;
Liskova, Aurelia;
Madrova, Nikola;
Alacova, Radka;
Zaichenko, Alexander;
Lesyk, Roman;
Horvathova, Mira;
Szabova, Michaela;
Lukan, Norbert;
Vari, Sandor

Publication type:

Article

Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one.

Published in:

Journal of Molecular Modeling, 2014, v. 20, n. 8, p. 1, doi. 10.1007/s00894-014-2366-6

By:

Nowaczyk, Alicja;
Fijałkowski, Łukasz;
Kowiel, Marcin;
Gzella, Andrzej;
Horishny, Volodymyr;
Lesyk, Roman

Publication type:

Article

Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro- and enterotoxicity on the stress model in rats.

Published in:

Minerva Biotechnology & Biomolecular Research, 2021, v. 33, n. 2, p. 117, doi. 10.23736/S2724-542X.21.02758-9

By:

FOMENKO, Iryna;
LOZYNSKA, Iryna;
BONDARCHUK, Tetyana;
DENYSENKO, Natalia;
LESYK, Roman;
SKLYAROV, Alexander

Publication type:

Article

ENZYMATIC OXIDATION OF THIAZOLIDINES IN THE PRESENCE OF CYCLODEXTRINS: EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE REACTANTS AND PRODUCTS.

Published in:

Acta Chemica Iaşi, 2024, v. 32, n. 2, p. 101, doi. 10.47743/achi-2024-2-0007

By:

Antonyuk, Volodymyr O.;
Manko, Nazar O.;
Panchak, Lidiia V.;
Bilyy, Rostyslav O.;
Bila, Halina I.;
Antonyuk, Lidiia Ya.;
Ghiarasim, Razvan;
Rotaru, Alexandru V.;
Lesyk, Roman B.

Publication type:

Article

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine.

Published in:

Nanomaterials (2079-4991), 2023, v. 13, n. 9, p. 1531, doi. 10.3390/nano13091531

By:

Sysak, Stepan;
Czarczynska-Goslinska, Beata;
Szyk, Piotr;
Koczorowski, Tomasz;
Mlynarczyk, Dariusz T.;
Szczolko, Wojciech;
Lesyk, Roman;
Goslinski, Tomasz

Publication type:

Article

L-3. Design and development of new thiazolidinone-based drug-like molecules.

Published in:

Biopolymers & Cell, 2019, v. 35, n. 3, p. 222, doi. 10.7124/bc.0009EC

By:

Lesyk, Roman;
Kaminskyy, Danylo;
Kryshchyshyn, Anna

Publication type:

Article

Recent developments with rhodanine as a scaffold for drug discovery.

Published in:

Expert Opinion on Drug Discovery, 2017, v. 12, n. 12, p. 1233, doi. 10.1080/17460441.2017.1388370

By:

Kaminskyy, Danylo;
Kryshchyshyn, Anna;
Lesyk, Roman

Publication type:

Article

Synthesis and anticancer activity of novel thiopyrano[2,3-d]thiazole-based compounds containing norbornane moiety.

Published in:

Journal of Sulfur Chemistry, 2008, v. 29, n. 2, p. 151, doi. 10.1080/17415990801911723

By:

Atamanyuk, Dmytro;
Zimenkovsky, Borys;
Lesyk, Roman

Publication type:

Article

Introducing bromine in the molecular structure as a good strategy to the drug design.

Published in:

Journal of Medical Science, 2024, v. 93, n. 3, p. 227, doi. 10.20883/medical.e1128

By:

Potapskyi, Eduard;
Kustrzyńska, Karolina;
Łażewski, Dawid;
Skupin-Mrugalska, Paulina;
Lesyk, Roman

Publication type:

Article

Drug design: 4-thiazolidinones applications. Part 2. Pharmacological profiles.

Published in:

Journal of Medical Science, 2020, v. 89, n. 2, p. 1, doi. 10.20883/medical.e407

By:

Lesyk, Roman

Publication type:

Article

Drug design: 4-thiazolidinones applications. Part 1. Synthetic routes to the drug-like molecules.

Published in:

Journal of Medical Science, 2020, v. 89, n. 1, p. 1, doi. 10.20883/medical.406

By:

Lesyk, Roman

Publication type:

Article

The Proapoptotic Action of Pyrrolidinedione–Thiazolidinone Hybrids towards Human Breast Carcinoma Cells Does Not Depend on Their Genotype.

Published in:

Cancers, 2024, v. 16, n. 16, p. 2924, doi. 10.3390/cancers16162924

By:

Finiuk, Nataliya;
Kozak, Yuliia;
Gornowicz, Agnieszka;
Czarnomysy, Robert;
Tynecka, Marlena;
Holota, Serhii;
Moniuszko, Marcin;
Stoika, Rostyslav;
Lesyk, Roman;
Bielawski, Krzysztof;
Bielawska, Anna

Publication type:

Article

Evaluation of thiopyrano[2,3‐d]thiazole derivatives as potential anticonvulsant agents.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 10, p. 1, doi. 10.1002/ardp.202400357

By:

Davydov, Eduard;
Hoidyk, Mykhailo;
Shtrygol', Sergiy;
Karkhut, Andriy;
Polovkovych, Svyatoslav;
Klyuchivska, Olga;
Karpenko, Olexandr;
Lesyk, Roman;
Holota, Serhii

Publication type:

Article

Anticancer 5‐arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones as tubulin inhibitors.

Published in:

Archiv der Pharmazie, 2022, v. 355, n. 12, p. 1, doi. 10.1002/ardp.202200419

By:

Rehulka, Jiri;
Subtelna, Ivanna;
Kryshchyshyn‐Dylevych, Anna;
Cherniienko, Alina;
Ivanova, Aleksandra;
Matveieva, Mariia;
Polishchuk, Pavel;
Gurska, Sona;
Hajduch, Marian;
Zagrijtschuk, Oleh;
Dzubak, Petr;
Lesyk, Roman

Publication type:

Article

5‐Arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones with selective inhibitory activity against some leukemia cell lines.

Published in:

Archiv der Pharmazie, 2021, v. 354, n. 4, p. 1, doi. 10.1002/ardp.202000342

By:

Subtelna, Ivanna;
Kryshchyshyn‐Dylevych, Anna;
Jia, Ruochen;
Lelyukh, Maryan;
Ringler, Anna;
Kubicek, Stefan;
Zagrijtschuk, Oleh;
Kralovics, Robert;
Lesyk, Roman

Publication type:

Article

Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates.

Published in:

Archiv der Pharmazie, 2011, v. 344, n. 8, p. 514, doi. 10.1002/ardp.201100055

By:

Havrylyuk, Dmytro;
Kovach, Natalya;
Zimenkovsky, Borys;
Vasylenko, Olexandr;
Lesyk, Roman

Publication type:

Article

Trastuzumab Potentiates Antitumor Activity of Thiopyrano[2,3- d ]Thiazole Derivative in AGS Gastric Cancer Cells.

Published in:

Molecules, 2024, v. 29, n. 21, p. 5117, doi. 10.3390/molecules29215117

By:

Roszczenko, Piotr;
Szewczyk-Roszczenko, Olga Klaudia;
Gornowicz, Agnieszka;
Czarnomysy, Robert;
Lozynskyi, Andrii;
Bielawski, Krzysztof;
Lesyk, Roman;
Bielawska, Anna

Publication type:

Article

Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs.

Published in:

Molecules, 2024, v. 29, n. 2, p. 346, doi. 10.3390/molecules29020346

By:

Janowska, Sara;
Holota, Serhii;
Lesyk, Roman;
Wujec, Monika

Publication type:

Article

1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3- d ]thiazoles as Potential Biologically Active Compounds.

Published in:

Molecules, 2022, v. 27, n. 21, p. 7575, doi. 10.3390/molecules27217575

By:

Lozynskyi, Andrii;
Senkiv, Julia;
Ivasechko, Iryna;
Finiuk, Nataliya;
Klyuchivska, Olga;
Kashchak, Nataliya;
Lesyk, Danylo;
Karkhut, Andriy;
Polovkovych, Svyatoslav;
Levytska, Oksana;
Karpenko, Olexandr;
Boshkayeva, Assyl;
Sayakova, Galiya;
Gzella, Andrzej;
Stoika, Rostyslav;
Lesyk, Roman

Publication type:

Article