Role and Merits of Green Based Nanocarriers in Cancer Treatment.

Elbagory, Abdulrahman M.; Marima, Rahaba Makgotso; Dlamini, Zodwa

Simple Summary: The use of chemotherapy drugs against tumours is associated with various drawbacks such as poor solubility, low stability, high toxicity, lack of selectivity and rapid clearance. Nanocarriers can improve the safety and efficiency of drugs by increasing their solubility, enhance their circulation time and improve their uptake into cancer cells. Natural materials can be incorporated in the fabrication of nanocarriers as a substitute to synthetic ingredients. Several studies developed different types of green based nanocarriers using materials obtained from plant or microbial sources such as polysaccharides and polyphenols without the need of toxic chemicals in the synthesis. The green components can have many roles for example as mechanical support, trigger pH response for drug release, or act as a targeting ligand. The inclusion of these green components will support the cost effective and feasible large-scale production of nanocarriers with minimum negative impact on the environment. The use of nanocarriers for biomedical applications has been gaining interests from researchers worldwide for the delivery of therapeutics in a controlled manner. These "smart" vehicles enhance the dissolution and the bioavailability of drugs and enable their delivery to the target site. Taking the potential toxicity into consideration, the incorporation of natural "green" materials, derived from plants or microbial sources, in the nanocarriers fabrication, improve their safety and biocompatibility. These green components can be used as a mechanical platform or as targeting ligand for the payload or can play a role in the synthesis of nanoparticles. Several studies reported the use of green based nanocarriers for the treatment of diseases such as cancer. This review article provides a critical analysis of the different types of green nanocarriers and their synthesis mechanisms, characterization, and their role in improving drug delivery of anticancer drugs to achieve precision cancer treatment. Current evidence suggests that green-based nanocarriers can constitute an effective treatment against cancer.

DRUG delivery systems; DRUG efficacy; ANTINEOPLASTIC agents; BIOMEDICAL materials; NANOTECHNOLOGY; TUMORS; PLANT extracts; NANOPARTICLES; PATIENT safety

Cancers, 2021, Vol 13, Issue 22, p5686

2072-6694

Academic Journal

10.3390/cancers13225686