Retinopathy of Prematurity and MicroRNAs.

Albanese, Giuseppe Maria; Visioli, Giacomo; Alisi, Ludovico; Armentano, Marta; Giovannetti, Francesca; Lucchino, Luca; Marenco, Marco; Pontecorvi, Paola; Gharbiya, Magda

Retinopathy of Prematurity (ROP), a leading cause of blindness in preterm infants, arises from dysregulated angiogenesis and inflammation. Without timely intervention, ROP can progress to severe outcomes, including dense fibrovascular plaques and retinal detachment. MicroRNAs (miRNAs) regulate key pathways such as hypoxia response, VEGF signaling, and vascular remodeling. Studies have identified miRNAs (e.g., miR-210, miR-146a, and miR-21) as potential biomarkers and therapeutic targets. Preclinical evidence supports miRNA-based therapies (e.g., miR-18a-5p and miR-181a), targeting HIF-1α and VEGFA to mitigate neovascularization, with nanoparticle delivery systems enhancing stability and specificity. These strategies, combined with anti-VEGF agents, show significant potential for improving ROP management. While promising, miRNA therapies require validation in clinical trials to ensure safety and efficacy. This review discusses the role of miRNAs in ROP, highlighting their relevance as diagnostic and therapeutic tools.

RETROLENTAL fibroplasia; VASCULAR remodeling; PREMATURE infants; RETINAL detachment; NEOVASCULARIZATION

Biomedicines, 2025, Vol 13, Issue 2, p400

2227-9059

Academic Journal

10.3390/biomedicines13020400