Works matching DE "DRUG target"

Results: 5000

EZH2 knockout in mice activates STAT3 signalling via STAT3 methylation and modulates ferroptosis in pulpitis‐affected dental pulp vascular endothelial cells: A laboratory investigation.

Published in:

International Endodontic Journal, 2025, v. 58, n. 7, p. 1025, doi. 10.1111/iej.14232

By:

Zhou, Weilin;
Huang, Weili;
You, Hongjing;
Zhang, Minyi;
Ma, Yue;
Liu, Lingjie;
Lin, Mengxuan;
He, Shuqi;
Huang, Yi

Publication type:

Article

Abnormalities of lipid metabolism in the progression and treatment of depression.

Published in:

Frontiers in Psychiatry, 2025, p. 1, doi. 10.3389/fpsyt.2025.1589663

By:

Luan, Xinchi;
Wang, Xuezhe;
Shi, Ying;
Zhang, Xinyi;
Wang, Yilin;
Zhou, Miao;
Wu, Zhaoyi;
Liu, Zijiao;
Li, Xiaoxuan;
Zhang, Lihua;
Shao, Tianyi;
Chen, Ruolan;
Chu, Xianming;
Wei, Hongyun

Publication type:

Article

泛素特异性蛋白酶在肝细胞癌中的作用.

Published in:

Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2025, v. 41, n. 5, p. 968, doi. 10.12449/JCH250525

By:

唐, 怡;
王, 国泰;
蒋, 雨涵

Publication type:

Article

血红素加氧酶在代谢相关脂肪性肝病中的作用及调控机制.

Published in:

Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2025, v. 41, n. 5, p. 948, doi. 10.12449/JCH250522

By:

费, 景兰;
李, 道政;
武, 俊超;
王, 雷

Publication type:

Article

SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02940-2

By:

Wu, Dali;
Zhong, Guanghui;
Liu, Yufeng;
Li, Cuilian;
Yan, Lingfei;
Luo, Yang;
Li, Qing;
Liu, Dawei;
Wang, Tao

Publication type:

Article

IGF1/IGF1R signaling promotes the expansion of liver CSCs and serves as a potential therapeutic target in HCC.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02890-9

By:

Tian, Qiuju;
Zhang, Qun;
Wang, Bin;
Qian, Yanzhi;
Liu, Fengchao

Publication type:

Article

The role of non-coding RNAs in the regulation of cell death pathways in melanoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02888-3

By:

Metanat, Yekta;
Sviridova, Maria;
Al-Nuaimi, Bareq N.;
Janbazi, Fateme;
Jalali, Mahtab;
Ghalamkarpour, Nogol;
Khodabandehloo, Elnaz;
Ahmadi, Ehsan

Publication type:

Article

A Soluble Expression Construct of the Isolated Catalytic Domain of Plasmodium falciparumATP4 Exhibits ATPase Activity Independent of a γ‐Phosphate Receiving Aspartate.

Published in:

Molecular Microbiology, 2025, v. 123, n. 6, p. 479, doi. 10.1111/mmi.15358

By:

Beyer, Timo;
Caliebe, Jesko;
Kähler, Lara;
Beitz, Eric

Publication type:

Article

Root remodeling mechanisms and salt tolerance trade-offs: The roles of HKT1, TMAC2, and TIP2;2 in Arabidopsis.

Published in:

PLoS Genetics, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pgen.1011713

By:

Alshareef, Nouf O.;
Melino, Vanessa J.;
Saber, Noha;
De Rosa, Annamaria;
Rey, Elodie;
Wang, Jian You;
AlBabili, Salim;
Byrt, Caitlin;
Tester, Mark A.;
Julkowska, Magdalena M.

Publication type:

Article

Functional Features of Senescent Cells and Implications for Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5390, doi. 10.3390/ijms26115390

By:

Kirichenko, Tatiana V.;
Markina, Yuliya V.;
Markin, Alexander M.;
Vasilyev, Vyacheslav S.;
Hua, Huiming;
Li, Dahong;
Woo, Anthony Yiu-Ho;
Deev, Roman V.;
Eremin, Ilya I.;
Kotenko, Konstantin V.

Publication type:

Article

Design, Synthesis, Anti-Tumor Activity and Molecular Docking Studies of Novel Triphenylphosphine-Containing Formononetin Derivatives.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5280, doi. 10.3390/ijms26115280

By:

Cui, Hongjuan;
Zhao, Yan;
Li, Wei;
Cui, Huanjie;
Han, Jiahong;
Cai, Enbo

Publication type:

Article

Sinhyotaklisan as a Potential Therapeutic for Psoriasis: Network Pharmacology and Experimental Validation.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5082, doi. 10.3390/ijms26115082

By:

Ahn, Jung-Yun;
Lim, Dong-Woo;
Kim, Jin-Hee;
Park, Sung-Yun;
Park, Sun-Dong;
Lee, Ju-Hee

Publication type:

Article

Protein Kinase A Regulates the Cell Cycle to Affect the Induction Rate in the Parthenogenetic Reproduction of the Silkworm, Bombyx mori.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 793, doi. 10.3390/cells14110793

By:

Xu, Fang;
Yu, Wei;
Ma, Chenkai;
Hu, Chengjie;
Cui, Chunguang;
Du, Xin;
Chen, Jine;
Zhu, Linbao;
Yu, Shaofang;
He, Xingjian;
Wang, Yongqiang;
Xu, Xia

Publication type:

Article

The cGAS/STING Pathway: Friend or Foe in Regulating Cardiomyopathy.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 778, doi. 10.3390/cells14110778

By:

Wang, Weiyue;
Gao, Yuanxu;
Lee, Hyun Kyoung;
Yu, Albert Cheung-Hoi;
Kipp, Markus;
Kaddatz, Hannes;
Zhan, Jiangshan

Publication type:

Article

Progranulin's Protective Mechanisms and Therapeutic Potential in Cardiovascular Disease.

Published in:

Cells (2073-4409), 2025, v. 14, n. 11, p. 762, doi. 10.3390/cells14110762

By:

Qiao, Gan;
Lu, Yongxiang;
Wu, Jianping;
Ren, Chunyang;
Lin, Roudian;
Zhang, Chunxiang

Publication type:

Article

Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02814-7

By:

Chen, Tianping;
Wei, Nan;
Lv, Wenxiu;
Qu, Lijun;
Qu, Qian;
Wu, Chaohong;
Ling, Yuan;
Liu, Haipeng;
Liu, Hongjun

Publication type:

Article

From Function to Mechanism: Unveiling the Role of Small Nucleolar Ribonucleic Acids in Digestive Tumours.

Published in:

Clinical Genetics, 2025, v. 107, n. 6, p. 587, doi. 10.1111/cge.14739

By:

Xi, Dongxin;
Sanbai, Guli Shayila Dui;
Jiang, Min;
Zhang, Zhihao;
Sun, Taoran;
Wang, Weijia;
Guo, Yu

Publication type:

Article

Application of Biologics in the Treatment of Asthma in the Past Two Decades: A Bibliometric Analysis and Beyond.

Published in:

Journal of Asthma & Allergy, 2025, v. 18, p. 779, doi. 10.2147/JAA.S514250

By:

Zhou, Zicong;
Chen, Xiaoying;
Liang, Shixiu;
Li, Jing;
Zhong, Nanshan;
Chen, Ruchong

Publication type:

Article

Evolving role of deubiquitinating enzymes in oral cancer (Review).

Published in:

Oncology Letters, 2025, v. 30, n. 1, p. N.PAG, doi. 10.3892/ol.2025.15100

By:

Wang, Zidi;
Cheng, Siyuan;
Wei, Jianhui;
Hu, Jiandong;
Li, Fenge;
Yang, Wenhua

Publication type:

Article

NETosis in myocardial ischemia-reperfusion injury: From mechanisms to therapies (Review).

Published in:

Biomedical Reports, 2025, v. 23, n. 1, p. N.PAG, doi. 10.3892/br.2025.1991

By:

Zhang, Ziyang;
Wang, Yanxin;
Li, Tie;
Wang, Hongfeng

Publication type:

Article

Unveiling the Therapeutic Potential of Targeting RRM2 in Hepatocellular Carcinoma: An Integrated In Silico and In Vitro Study.

Published in:

Functional & Integrative Genomics, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10142-025-01630-0

By:

Ibrahim, Lobna;
Mohamed, Rania Hassan;
Tolba, Mahmoud M.;
Radwan, Sara M.;
Hamdy, Nadia M.;
Elhefnawi, Mahmoud

Publication type:

Article

TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1583235

By:

Zhou, Ting;
Zhang, Ziyao;
Zhan, Yawen;
Wang, Meiying;
Wu, Mi;
Weng, Xiufang;
Xu, Younian

Publication type:

Article

MultiV_Nm: a prediction method for 2′-O-methylation sites based on multi-view features.

Published in:

Frontiers in Genetics, 2025, p. 1, doi. 10.3389/fgene.2025.1608490

By:

Bai, Lei;
Liu, Fei;
Wang, Yile;
Su, Junle;
Liu, Lian

Publication type:

Article

GAS6/AXL signaling promotes M2 microglia efferocytosis to alleviate neuroinflammation in sepsis-associated encephalopathy.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02507-8

By:

Tang, Yuedong;
Hu, Hanbing;
Xie, Qiliang;
Shen, Jie

Publication type:

Article

Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.104859

By:

Yu-Chia Chen;
Mamoru Takada;
Aerica Nagornyuk;
Muhan Yu;
Hideyuki Yamada;
Takeshi Nagashima;
Masayuki Ohtsuka;
DeLuca, Jennifer G.;
Markus, Steven M.;
Motoki Takaku;
Aussie Suzuki

Publication type:

Article

Endometriosis is not the endometrium: Reviewing the over-representation of eutopic endometrium in endometriosis research.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.103825

By:

Gunther, Kate;
Fisher, Teagan;
Liu, Dongli;
Abbott, Jason;
Ford, Caroline Elizabeth

Publication type:

Article

Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications.

Published in:

Brain Pathology, 2025, v. 35, n. 4, p. 1, doi. 10.1111/bpa.13328

By:

Fabbrizio, Paola;
Baindoor, Sharada;
Margotta, Cassandra;
Su, Junyi;
Morrissey, Elena P.;
Woods, Ina;
Hogg, Marion C.;
Vianello, Sara;
Venø, Morten T.;
Kjems, Jørgen;
Sorarù, Gianni;
Bendotti, Caterina;
Prehn, Jochen H. M.;
Nardo, Giovanni

Publication type:

Article

Identification of therapeutic targets in lung adenocarcinoma using Mendelian randomization and multi-omics.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02835-2

By:

Li, Yue;
Ma, Keru;
Wang, Hao;
Liu, Zongying;
Li, Zhuying

Publication type:

Article

Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02783-x

By:

Nandan, Parmar Keshri;
Sivaraman, Jayanthi

Publication type:

Article

Current developments on antimalarial drugs and mechanisms of resistance to antimalarials.

Published in:

Microbes & Infectious Diseases, 2025, v. 6, n. 2, p. 929, doi. 10.21608/MID.2024.263234.1763

By:

Benjamin, Gideon Yakusak

Publication type:

Article

赤芝酸 B 抗结直肠癌作用的网络药理学及分子生物学机制研究.

Published in:

Progress in Modern Biomedicine, 2025, v. 25, n. 8, p. 1307, doi. 10.13241/j.cnki.pmb.2025.08.004

By:

涛;
陈小娟;
张伍林;
许丽;
潘勇;
李顺祥

Publication type:

Article

Current cutting-edge omics techniques on musculoskeletal tissues and diseases.

Published in:

Bone Research, 2025, v. 13, n. 1, p. 1, doi. 10.1038/s41413-025-00442-z

By:

Li, Xiaofei;
Fang, Liang;
Zhou, Renpeng;
Yao, Lutian;
Clayton, Sade W.;
Muscat, Samantha;
Kamm, Dakota R.;
Wang, Cuicui;
Liu, Chuan-Ju;
Qin, Ling;
Tower, Robert J.;
Karner, Courtney M.;
Guilak, Farshid;
Tang, Simon Y.;
Loiselle, Alayna E.;
Meyer, Gretchen A.;
Shen, Jie

Publication type:

Article

A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis.

Published in:

Graefe's Archive of Clinical & Experimental Ophthalmology, 2025, v. 263, n. 5, p. 1307, doi. 10.1007/s00417-024-06723-3

By:

Zhang, Kaiyun;
Chen, Li;
Qu, Laiqiang;
Yan, Hong

Publication type:

Article

Integrated bioinformatics and functional studies identify CDK9 as a potential prognostic biomarker and therapeutic target in AML.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02841-4

By:

Xie, Zhibin;
Xia, Yang;
Li, Zhongyu;
Zhang, Mengmeng;
Tan, Yuanyuan;
Han, Yuqing;
Wang, Meng;
Zhang, Pingping;
Li, Jiajia

Publication type:

Article

Mir-509-3p targets SLC25A13 to regulate ferroptosis and protect retinal endothelial cells in diabetic retinopathy.

Published in:

Acta Diabetologica, 2025, v. 62, n. 6, p. 831, doi. 10.1007/s00592-024-02400-3

By:

Ren, Meiqing;
Xu, Qian;
Luan, Jie;
Ni, Yan;
Xie, Bo

Publication type:

Article

Lactate metabolism-related genes serve as potential biomarkers for predicting gastric cancer progression and immunotherapy.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02782-y

By:

Yuan, Mingjie;
Li, Xuekai;
Song, Xuanli;
Chen, Xiaowei;
Wang, Yunshan;
Han, Shuyi;
Ni, Yang;
Liu, Duanrui

Publication type:

Article

Gut Microbiota in Lactose Intolerance: A Mendelian Randomization Study on Microbial Mechanisms and Potential Links to Tumor Inflammatory Microenvironments.

Published in:

Mediators of Inflammation, 2025, v. 2025, p. 1, doi. 10.1155/mi/8181816

By:

Xie, Ya;
Cao, Qiongjiao;
Huang, Zhen;
Zou, Xin;
Liu, Hengrui

Publication type:

Article

Study on DNA Damage Gene in Spermatogonial Stem Cells from Idiopathic Nonobstructive Azoospermia: A Bioinformatics Investigation Based on scRNA-seq Data.

Published in:

Cytogenetic & Genome Research, 2025, v. 165, n. 1, p. 9, doi. 10.1159/000545275

By:

Wang, Yi;
Weng, Yiming;
Wang, Yanqiu;
Xiang, Jun;
Le, Wei

Publication type:

Article

Metabotropic glutamate receptors 2 and 3 as targets for treating schizophrenia.

Published in:

European Journal of Clinical & Experimental Medicine, 2025, v. 23, p. 67

By:

Niemiec, Hubert;
Zawodnik, Zuzanna;
Pańczyszyn-Trzewik, Patrycja;
Sowa-Kućma, Magdalena

Publication type:

Article

A retrospective comparative study: Novel diagnostical markers of inflammation and cardiovascular risk of bipolar disorder and manic episode.

Published in:

Annals of Medical of Research, 2025, v. 32, n. 5, p. 199, doi. 10.5455/annalsmedres.2025.01.019

By:

Tozoglu, Elif Ozcan

Publication type:

Article

RETRACTION: Identification of Potential Therapeutic Targets for Breast Cancer Using Mendelian Randomization Analysis and Drug Target Prediction.

Published in:: 2025
Publication type:: Correction Notice

RETRACTED: RSPO2‐associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer.

Published in:

Environmental Toxicology, 2025, v. 40, n. 7, p. E124, doi. 10.1002/tox.24209

By:

Peng, Quanzhou;
Cao, Tianfeng;
Yang, Xue;
Ye, Zhujia;
Wang, Jun;
Chen, Shang;
Yu, Yanqi;
Yu, Yingdian;
Xue, Wenyuan;
Chen, Zhiwei;
Fan, Jianbing

Publication type:

Article

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202408158

By:

Pemberton, Joshua G.;
Barlow-Busch, Isobel;
Jenkins, Meredith L.;
Parson, Matthew A. H.;
Sarnyai, Farkas;
Bektas, Seyma Nur;
Yeun Ju Kim;
Heuser, John E.;
Burke, John E.;
Balla, Tamas

Publication type:

Article

The Abelson kinase and the Nedd4 family E3 ligases co-regulate Notch trafficking to limit signaling.

Published in:

Journal of Cell Biology, 2025, v. 224, n. 6, p. 1, doi. 10.1083/jcb.202407066

By:

Miranda-Alban, Julio;
Sanchez-Luege, Nicelio;
Valbuena, Fernando M.;
Rangel, Chyan;
Rebay, Ilaria

Publication type:

Article

Neutrophil extracellular traps in central nervous system disorders: mechanisms, implications, and emerging perspective.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1602336

By:

Qiao, Shan;
Yuan, Jing;
Zhang, Shan-chao;
Lu, Ying-ying;
Zhou, Peng;
Xin, Tao

Publication type:

Article

PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate–Induced Colitis and Modulate Gut Microbiota.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1536, doi. 10.1111/jgh.16929

By:

Li, Jian‐Hong;
Xu, Jing;
Hu, Jin‐Xia;
Xu, Hao‐Ming;
Guo, Xue;
Zhang, Yan;
Xu, Jing‐Kui;
Huang, Chen;
Nie, Yu‐Qiang;
Zhou, You‐Lian

Publication type:

Article

Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics.

Published in:

Journal of Gastroenterology & Hepatology, 2025, v. 40, n. 6, p. 1602, doi. 10.1111/jgh.16897

By:

Guo, Xiaoyan;
Wu, Lili;
Lai, Jing;
Wu, Yuankai;
Chen, Dianke

Publication type:

Article

"A REVIEW ON MICROEMULSION AND MICROSPHERE : A PROMISING OPTIMIZING TECHNIQUE FOR ADVANCED DRUG DELIVERY SYSTEM".

Published in:

Bulletin of Pure & Applied Sciences-Zoology, 2024, v. 43, p. 641

By:

Avinash, Chavan;
Kulkarni, A. S.;
Phalake, R. A.;
Sawant, Prachi;
Bade, Omkesh;
Kandurkar, Prafull;
Patil, Prajakta;
Sawant, Pramod

Publication type:

Article

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti.

Published in:

PLoS Pathogens, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.ppat.1013221

By:

Guarnaschelli, Inés;
Koziol, Uriel

Publication type:

Article

KMT2A重排急性髓系白血病的研究进展.

Published in:

Journal of Nanjing Medical University: Natural Sciences, 2025, v. 45, n. 5, p. 718, doi. 10.7655/NYDXBNSN241470

By:

李佳欣;
陶善东;
于亮

Publication type:

Article