Results
Title

Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities.

Authors

Veglia Tranchese, Roberta; Battista, Sabrina; Cerchia, Laura; Fedele, Monica

Abstract

Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical pathway in cancer biology. This review delves into the epigenetic mechanisms that modulate ferroptosis in cancer cells, focusing on how DNA methylation, histone modifications, and non-coding RNAs influence the expression and function of essential genes involved in this process. By unraveling the complex interplay between these epigenetic mechanisms and ferroptosis, the article sheds light on novel gene targets and functional insights that could pave the way for innovative cancer treatments to enhance therapeutic efficacy and overcome resistance in cancer therapy.

Subjects

NON-coding RNA; DNA methylation; GENE targeting; CANCER treatment; CELL death; EPIGENOMICS

Publication

Biomolecules (2218-273X), 2024, Vol 14, Issue 11, p1443

ISSN

2218-273X

Publication type

Academic Journal

DOI

10.3390/biom14111443