Results
Title

Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment.

Authors

A. Mumuni, Momoh; E. Calister, Ugwu; Aminu, Nafiu; C. Franklin, Kenechukwu; Musiliu Oluseun, Adedokun; Usman, Mohammed; Abdulmumuni, Barikisu; Y. James, Oyeniyi; C. Ofokansi, Kenneth; A. Anthony, Attama; C. Ibezim, Emmanuel; Díaz Díaz, David

Abstract

In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.

Subjects

INSULIN; BLOOD sugar; PEOPLE with diabetes

Publication

Applied Sciences (2076-3417), 2020, Vol 10, Issue 8, p2649

ISSN

2076-3417

Publication type

Academic Journal

DOI

10.3390/app10082649