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Title

Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils.

Authors

Li, Yurong; Li, Wenji; Ye, Zimao; Ji, Chen; Zhou, Zhiqin

Abstract

Citrus peel essential oil (CPEO) is favored by people for its aromatic scent, while also possessing numerous bioactive compounds that are advantageous to human health. This study evaluated the antioxidant, anti-inflammatory, and anticancer activities of CPEOs through cell experiments. The results showed that CPEOs could increase the activity of the antioxidant enzyme system and nonenzymatic defence system in H2O2-treated RAW 264.7 cells by reducing cellular lipid peroxidation. CPEOs also reduced the nitric oxide production induced by lipopolysaccharide treatment in RAW 264.7 cells while decreasing proinflammatory cytokines expression and increasing anti-inflammatory cytokine expression. Wound healing assays, flow cytometry, and quantitative real-time fluorescent quantitative PCR (qRT-PCR) revealed that CPEOs could induce apoptosis in U87 cells through the mitochondrial apoptotic pathway. These findings indicate that CPEOs possess excellent antioxidant, anti-inflammatory, and anticancer activity potential, making them suitable for use in functional antioxidant and anti-inflammatory foods and nutritional health products.

Subjects

ESSENTIAL oils; BIOACTIVE compounds; ANTINEOPLASTIC agents; WOUND healing; FLOW cytometry

Publication

Antioxidants, 2024, Vol 13, Issue 12, p1562

ISSN

2076-3921

Publication type

Academic Journal

DOI

10.3390/antiox13121562

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