Title: Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts.
Authors: Park, Hyun-Jung; Yoon, Sun-Young; Park, Jung-Nam; Suh, Jae-Hee; Choi, Hye-Seon
Abstract: To investigate the mechanism of doxorubicin (DOX)-induced bone loss, µCT scans of femurs from mice injected 3-MA or vehicle after treatment with DOX were analyzed. Recent work has suggested an involvement of autophagy in DOX resistance [[20]] and DOX-induced cardiotoxicity [[21]], suggesting that the effect of DOX on bone density may be mediated by autophagy. DOX-treated breast cancer patients exhibit low bone mineral density [[13]] and DOX-treated children also undergo long-term bone damage [[15]], suggesting that there is a strong association between DOX treatment and bone loss.
Subjects: OSTEOCLASTS; TRP channels; AUTOPHAGY; DOXORUBICIN; MITOCHONDRIA; OSTEITIS deformans; TRANSFORMING growth factors
Publication: Antioxidants, 2022, Vol 11, Issue 8, pN.PAG
ISSN: 2076-3921
Publication type: Academic Journal
DOI: 10.3390/antiox11081476

Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts.

Park, Hyun-Jung; Yoon, Sun-Young; Park, Jung-Nam; Suh, Jae-Hee; Choi, Hye-Seon