Works matching DE "KINASE inhibitors"

Results: 3161

Notch is a direct negative regulator of the DNA-damage response.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 417, doi. 10.1038/nsmb.3013

By:

Vermezovic, Jelena;
Adamowicz, Marek;
Santarpia, Libero;
Rustighi, Alessandra;
Forcato, Mattia;
Lucano, Caterina;
Massimiliano, Lucia;
Costanzo, Vincenzo;
Bicciato, Silvio;
Del Sal, Giannino;
d'Adda di Fagagna, Fabrizio

Publication type:

Article

Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma<sup>*</sup> Elevated serum thymidine kinase activity in canine splenic hemangiosarcoma.

Published in:

Veterinary & Comparative Oncology, 2012, v. 10, n. 4, p. 292, doi. 10.1111/j.1476-5829.2011.00298.x

By:

Thamm, D. H.;
Kamstock, D. A.;
Sharp, C. R.;
Johnson, S. I.;
Mazzaferro, E.;
Herold, L. V.;
Barnes, S. M.;
Winkler, K.;
Selting, K. A.

Publication type:

Article

A Phosphoramidate Prodrug Platform: One‐Pot Amine Functionalization of Kinase Inhibitors with Oligoethylene Glycol for Improved Water‐Solubility.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 49, p. 1, doi. 10.1002/chem.202401781

By:

Spiewok, Sarah;
Lamla, Markus;
Schaefer, Maximilian;
Kuehne, Alexander J. C.

Publication type:

Article

Cover Feature: Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor (Chem. Eur. J. 23/2023).

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 23, p. 1, doi. 10.1002/chem.202300918

By:

Tröster, Alix;
DiPrima, Michael;
Jores, Nathalie;
Kudlinzki, Denis;
Sreeramulu, Sridhar;
Gande, Santosh L.;
Linhard, Verena;
Ludig, Damian;
Schug, Alexander;
Saxena, Krishna;
Reinecke, Maria;
Heinzlmeir, Stephanie;
Leisegang, Matthias S.;
Wollenhaupt, Jan;
Lennartz, Frank;
Weiss, Manfred S.;
Kuster, Bernhard;
Tosato, Giovanna;
Schwalbe, Harald

Publication type:

Article

Elucidating the potential effects of point mutations on FGFR3 inhibitor resistance via combined molecular dynamics simulation and community network analysis.

Published in:

Journal of Computer-Aided Molecular Design, 2023, v. 37, n. 7, p. 325, doi. 10.1007/s10822-023-00510-8

By:

Liu, Bo;
Ding, Juntao;
Liu, Yugang;
Wu, Jianzhang;
Wu, Xiaoping;
Chen, Qian;
Li, Wulan

Publication type:

Article

Target identification for repurposed drugs active against SARS-CoV-2 via high-throughput inverse docking.

Published in:

Journal of Computer-Aided Molecular Design, 2022, v. 36, n. 1, p. 25, doi. 10.1007/s10822-021-00432-3

By:

Ribone, Sergio R.;
Paz, S. Alexis;
Abrams, Cameron F.;
Villarreal, Marcos A.

Publication type:

Article

A new method for estimating the relative binding free energy, derived from a free energy variational principle for the Pim-1-kinase–ligand and FKBP–ligand systems.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 6, p. 647, doi. 10.1007/s10822-020-00302-4

By:

Ashida, Takeshi;
Kikuchi, Takeshi

Publication type:

Article

Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 6, p. 671, doi. 10.1007/s10822-020-00297-y

By:

Rajan, Ravi Kumar;
Ramanathan, M.

Publication type:

Article

Predicting octanol/water partition coefficients for the SAMPL6 challenge using the SM12, SM8, and SMD solvation models.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 5, p. 575, doi. 10.1007/s10822-020-00293-2

By:

Ouimet, Jonathan A.;
Paluch, Andrew S.

Publication type:

Article

Octanol–water partition coefficient measurements for the SAMPL6 blind prediction challenge.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 4, p. 405, doi. 10.1007/s10822-019-00271-3

By:

Işık, Mehtap;
Levorse, Dorothy;
Mobley, David L.;
Rhodes, Timothy;
Chodera, John D.

Publication type:

Article

Data structures for computational compound promiscuity analysis and exemplary applications to inhibitors of the human kinome.

Published in:

Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 1, p. 1, doi. 10.1007/s10822-019-00266-0

By:

Miljković, Filip;
Bajorath, Jürgen

Publication type:

Article

Systematic computational identification of promiscuity cliff pathways formed by inhibitors of the human kinome.

Published in:

Journal of Computer-Aided Molecular Design, 2019, v. 33, n. 6, p. 559, doi. 10.1007/s10822-019-00198-9

By:

Miljković, Filip;
Vogt, Martin;
Bajorath, Jürgen

Publication type:

Article

pK<sub>a</sub> measurements for the SAMPL6 prediction challenge for a set of kinase inhibitor-like fragments.

Published in:

Journal of Computer-Aided Molecular Design, 2018, v. 32, n. 10, p. 1117, doi. 10.1007/s10822-018-0168-0

By:

Işık, Mehtap;
Levorse, Dorothy;
Rustenburg, Ariën S.;
Ndukwe, Ikenna E.;
Wang, Heather;
Wang, Xiao;
Reibarkh, Mikhail;
Martin, Gary E.;
Makarov, Alexey A.;
Mobley, David L.;
Rhodes, Timothy;
Chodera, John D.

Publication type:

Article

Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.

Published in:

Journal of Computer-Aided Molecular Design, 2016, v. 30, n. 1, p. 39, doi. 10.1007/s10822-015-9887-7

By:

Shahin, Rand;
Swellmeen, Lubna;
Shaheen, Omar;
Aboalhaija, Nour;
Habash, Maha

Publication type:

Article

Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2015, v. 29, n. 6, p. 561, doi. 10.1007/s10822-015-9848-1

By:

Jaradat, Nour;
Khanfar, Mohammad;
Habash, Maha;
Taha, Mutasem

Publication type:

Article

Gastrointestinal stromal tumor: a review of current and emerging therapies.

Published in:

Cancer & Metastasis Reviews, 2021, v. 40, n. 2, p. 625, doi. 10.1007/s10555-021-09961-7

By:

Al-Share, Bayan;
Alloghbi, Abdulrahman;
Al Hallak, Mohammed Najeeb;
Uddin, Hafiz;
Azmi, Asfar;
Mohammad, Ramzi M.;
Kim, Steve H;
Shields, Anthony F.;
Philip, Philip A

Publication type:

Article

Pre-transplant utilization of sorafenib is not associated with increased complications after liver transplantation.

Published in:

Transplant International, 2013, v. 26, n. 7, p. 734, doi. 10.1111/tri.12117

By:

Frenette, Catherine T.;
Boktour, Maha;
Burroughs, Sherilyn G.;
Kaseb, Ahmed;
Aloia, Thomas A.;
Galati, Joseph;
Gaber, Ahmed O.;
Monsour, Howard;
Ghobrial, Rafik M.

Publication type:

Article

Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology.

Published in:

Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 6, p. 1101, doi. 10.1007/s00417-019-04283-5

By:

Moura-Coelho, Nuno;
Tavares Ferreira, Joana;
Bruxelas, Carolina Pereira;
Dutra-Medeiros, Marco;
Cunha, João Paulo;
Pinto Proença, Rita

Publication type:

Article

Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats.

Published in:

Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 2, p. 303, doi. 10.1007/s00417-018-4191-6

By:

Wada, Yasushi;
Higashide, Tomomi;
Nagata, Atsushi;
Sugiyama, Kazuhisa

Publication type:

Article

RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.

Published in:

Graefe's Archive of Clinical & Experimental Ophthalmology, 2019, v. 257, n. 1, p. 101, doi. 10.1007/s00417-018-4175-6

By:

Dang, Yalong;
Wang, Chao;
Shah, Priyal;
Waxman, Susannah;
Loewen, Ralitsa T.;
Loewen, Nils A.

Publication type:

Article

Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS-126 in models of ovarian cancer.

Published in:

Archives of Gynecology & Obstetrics, 2015, v. 291, n. 1, p. 131, doi. 10.1007/s00404-014-3389-z

By:

Hahne, Jens;
Kurz, Antje;
Meyer, Susanne;
Dietl, Johannes;
Engel, Jörg;
Honig, Arnd

Publication type:

Article

Sequential combination of flavopiridol with Taxol synergistically suppresses human ovarian carcinoma growth.

Published in:

Archives of Gynecology & Obstetrics, 2015, v. 291, n. 1, p. 143, doi. 10.1007/s00404-014-3408-0

By:

Song, Yue;
Xin, Xing;
Zhai, Xingyue;
Xia, Zhijun;
Shen, Keng

Publication type:

Article

Aurora kinase inhibitor AZD1152 has an additional effect of platinum on a sequential application at the human ovarian cancer cell line SKOV3.

Published in:

Archives of Gynecology & Obstetrics, 2013, v. 288, n. 1, p. 173, doi. 10.1007/s00404-013-2719-x

By:

Ma, Yaxi;
Weimer, Jörg;
Fredrik, Regina;
Adam-Klages, Sabine;
Sebens, Susanne;
Caliebe, Amke;
Hilpert, Felix;
Eckmann-Scholz, Christel;
Arnold, Norbert;
Schem, Christian

Publication type:

Article

Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 6, p. 1071, doi. 10.1007/s00401-020-02155-5

By:

Mondal, Gourish;
Lee, Julieann C.;
Ravindranathan, Ajay;
Villanueva-Meyer, Javier E.;
Tran, Quynh T.;
Allen, Sariah J.;
Barreto, Jairo;
Gupta, Rohit;
Doo, Pamela;
Van Ziffle, Jessica;
Onodera, Courtney;
Devine, Patrick;
Grenert, James P.;
Samuel, David;
Li, Rong;
Metrock, Laura K.;
Jin, Lee-way;
Antony, Reuben;
Alashari, Mouied;
Cheshier, Samuel

Publication type:

Article

Mediator kinase inhibition further activates super-enhancer-associated genes in AML.

Published in:

Nature, 2015, v. 526, n. 7572, p. 273, doi. 10.1038/nature14904

By:

Pelish, Henry E.;
Liau, Brian B.;
Nitulescu, Ioana I.;
Tangpeerachaikul, Anupong;
Poss, Zachary C.;
Da Silva, Diogo H.;
Caruso, Brittany T.;
Arefolov, Alexander;
Fadeyi, Olugbeminiyi;
Christie, Amanda L.;
Du, Karrie;
Banka, Deepti;
Schneider, Elisabeth V.;
Jestel, Anja;
Zou, Ge;
Si, Chong;
Ebmeier, Christopher C.;
Bronson, Roderick T.;
Krivtsov, Andrei V.;
Myers, Andrew G.

Publication type:

Article

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Published in:

Nature, 2015, v. 521, n. 7553, p. 541, doi. 10.1038/nature14328

By:

Xu, Guotai;
Chapman, J. Ross;
Brandsma, Inger;
Yuan, Jingsong;
Mistrik, Martin;
Bouwman, Peter;
Bartkova, Jirina;
Gogola, Ewa;
Warmerdam, Daniël;
Barazas, Marco;
Jaspers, Janneke E.;
Watanabe, Kenji;
Pieterse, Mark;
Kersbergen, Ariena;
Sol, Wendy;
Celie, Patrick H. N.;
Schouten, Philip C.;
van den Broek, Bram;
Salman, Ahmed;
Nieuwland, Marja

Publication type:

Article

Drug development: Mix and match.

Published in:

Nature, 2015, v. 521, n. 7551, p. S12, doi. 10.1038/521S12a

By:

Scudellari, Megan

Publication type:

Article

Therapy-induced tumour secretomes promote resistance and tumour progression.

Published in:

Nature, 2015, v. 520, n. 7547, p. 368, doi. 10.1038/nature14336

By:

Obenauf, Anna C.;
Zou, Yilong;
Ji, Andrew L.;
Vanharanta, Sakari;
Shu, Weiping;
Shi, Hubing;
Kong, Xiangju;
Bosenberg, Marcus C.;
Wiesner, Thomas;
Rosen, Neal;
Lo, Roger S.;
Massagué, Joan

Publication type:

Article

Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Published in:

Nature, 2014, v. 513, n. 7519, p. 512, doi. 10.1038/nature13495

By:

Dail, Monique;
Wong, Jason;
Lawrence, Jessica;
O'Connor, Daniel;
Xu, Jin;
Shannon, Kevin;
Nakitandwe, Joy;
Chen, Shann-Ching;
Downing, James R.;
Lee, Leslie B.;
Sampath, Deepak;
Akagi, Keiko;
Li, Qing;
Aster, Jon C.;
Pear, Warren S.

Publication type:

Article

Upadacitinib therapy as a successful treatment of severe atopic dermatitis in a patient with a previous dupilumab-induced exanthematous drug reaction.

Published in:

2024

By:

Kucharczyk, Monika;
Cudzik-Dziurzyńska, Joanna;
Błaszczyk, Aleksandra;
Lewitowicz, Piotr;
Kręcisz, Beata

Publication type:

Case Study

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition.

Published in:

BioDiscovery, 2017, p. 1, doi. 10.7750/BioDiscovery.2013.9.4

By:

Idowu, Michael A.;
Khalil, Hilal S.;
Bown, James L.;
Zhelev, Nikolai

Publication type:

Article

Phosphorylase Kinase Inhibition Therapy in Burns and Scalds.

Published in:

BioDiscovery, 2017, p. 1, doi. 10.3897/biodiscovery.20.e11207

By:

Heng, Madalene

Publication type:

Article

Comparable Outcomes of Pre-Versus Post-Tyrosine Kinase Inhibitor Era Treatment in Chronic Myeloid Leukemia: A Retrospective Cohort Study With Long-term Follow-up.

Published in:

Cell Transplantation, 2023, v. 32, p. 1, doi. 10.1177/09636897231163212

By:

Tavakoli, Sahar;
Khalaj, Fattaneh;
Kasaeian, Amir;
Mousavi, Seyed Ali;
Mousavian, Amir-Hossein;
Arabi, Fatemeh;
Rad, Soroush;
Rostami, Shahrbano;
Barkhordar, Maryam;
Biglari, Mohammad;
Mardani-Fard, Heydar Ali;
Alemi, Hediyeh;
Khavandgar, Naghmeh;
Kamranzadeh Fumani, Hossein;
Janbabai, Ghasem;
Mousavi, Seied Asadollah;
Ghavamzadeh, Ardeshir;
Vaezi, Mohammad

Publication type:

Article

TCR signaling: the barrier within.

Published in:

Nature Immunology, 2014, v. 15, n. 2, p. 136, doi. 10.1038/ni.2811

By:

Dustin, Michael L;
Davis, Simon J

Publication type:

Article

Virus-induced autophagy.

Published in:

Nature Immunology, 2014, v. 15, n. 2, p. 142, doi. 10.1038/ni.2817

By:

Dempsey, Laurie A

Publication type:

Article

Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.

Published in:

Nature Immunology, 2014, v. 15, n. 2, p. 186, doi. 10.1038/ni.2772

By:

Tan, Ying Xim;
Manz, Boryana N;
Freedman, Tanya S;
Zhang, Chao;
Shokat, Kevan M;
Weiss, Arthur

Publication type:

Article

RKIP expression of liver and kidney after arsenic exposure.

Published in:

Environmental Toxicology, 2017, v. 32, n. 3, p. 1079, doi. 10.1002/tox.22291

By:

Tsao, Der‐An;
Tseng, Wei‐Chang;
Chang, Huoy‐Rou

Publication type:

Article

Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma.

Published in:

NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0075-y

By:

Del Mistro, Greta;
Lucarelli, Philippe;
Müller, Ines;
De Landtsheer, Sébastien;
Zinoveva, Anna;
Hutt, Meike;
Siegemund, Martin;
Kontermann, Roland E.;
Beissert, Stefan;
Sauter, Thomas;
Kulms, Dagmar

Publication type:

Article

Large-scale computational drug repositioning to find treatments for rare diseases.

Published in:

NPJ Systems Biology & Applications, 2018, v. 4, n. 1, p. N.PAG, doi. 10.1038/s41540-018-0050-7

By:

Govindaraj, Rajiv Gandhi;
Naderi, Misagh;
Singha, Manali;
Lemoine, Jeffrey;
Brylinski, Michal

Publication type:

Article

Analysis of the pharmacoeconomic effectiveness of the tyrosine kinase inhibitors therapy in patients with chronic myeloid leukemia in a Single Hematology Center in Plovdiv, Bulgaria.

Published in:

Pharmacia (0428-0296), 2024, v. 71, n. 1, p. 1, doi. 10.3897/pharmacia.71.e126016

By:

Goranova-Marinova, Veselina;
Grekova-Kafalova, Daniela;
Andreevska, Kalina;
Georgieva, Vania;
Gvozdeva, Yana;
Kassarova, Margarita;
Grudeva-Popova, Zhanet;
Gavazova, Evelina;
Petkova, Valentina

Publication type:

Article

Application of biological medicinal products and tyrosine kinase inhibitors in rheumatoid arthritis and COVID-19: A systematic review of scientific literature.

Published in:

Pharmacia (0428-0296), 2024, v. 71, n. 1, p. 1, doi. 10.3897/pharmacia.71.e124471

By:

Parvova, Iva;
Yordanov, Emanuil;
Hristov, Emil;
Petkova, Valentina

Publication type:

Article

Analysis of the pharmacotherapeutic effectiveness of the tyrosine kinase inhibitors therapy in patients with Chronic Myeloid Leukemia in a single hematology center in Plovdiv, Bulgaria.

Published in:

Pharmacia (0428-0296), 2023, v. 70, n. 4, p. 1355, doi. 10.3897/pharmacia.70.e111923

By:

Goranova-Marinova, Veselina;
Grekova, Daniela;
Georgieva, Vania;
Andreevska, Kalina;
Gvozdeva, Yana;
Kassarova, Margarita;
Grudeva-Popova, Zhanet

Publication type:

Article

Early-stage breast cancer: Update on management.

Published in:

Medicine Today, 2024, v. 25, n. 3, p. 45

By:

OFRI, ADAM;
REBECCA CUI;
ELSTNER, KRISTEN;
KUMAR, SANJEEV;
WARRIER, SANJAY

Publication type:

Article

Bacterial Histidine Kinase and the Development of Its Inhibitors in the 21st Century.

Published in:

Antibiotics (2079-6382), 2024, v. 13, n. 7, p. 576, doi. 10.3390/antibiotics13070576

By:

Ahsan, Ragib;
Kifayat, Sumaiya;
Pooniya, Krishan Kumar;
Kularia, Sunita;
Adimalla, Bhavani Sailu;
Sanapalli, Bharat Kumar Reddy;
Sanapalli, Vidyasrilekha;
Sigalapalli, Dilep Kumar

Publication type:

Article

Utilization of Existing Human Kinase Inhibitors as Scaffolds in the Development of New Antimicrobials.

Published in:

Antibiotics (2079-6382), 2023, v. 12, n. 9, p. 1418, doi. 10.3390/antibiotics12091418

By:

Konaklieva, Monika I.;
Plotkin, Balbina J.

Publication type:

Article

Quercetin Is a Novel Inhibitor of the Choline Kinase of Streptococcus pneumoniae.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 9, p. 1272, doi. 10.3390/antibiotics11091272

By:

Zimmerman, Tahl;
Ibrahim, Salam A.

Publication type:

Article

Computational Design of Inhibitors Targeting the Catalytic β Subunit of Escherichia coli F O F 1 -ATP Synthase.

Published in:

Antibiotics (2079-6382), 2022, v. 11, n. 5, p. 557, doi. 10.3390/antibiotics11050557

By:

Avila-Barrientos, Luis Pablo;
Cofas-Vargas, Luis Fernando;
Agüero-Chapin, Guillermin;
Hernández-García, Enrique;
Ruiz-Carmona, Sergio;
Valdez-Cruz, Norma A.;
Trujillo-Roldán, Mauricio;
Weber, Joachim;
Ruiz-Blanco, Yasser B.;
Barril, Xavier;
García-Hernández, Enrique

Publication type:

Article

Kinase Inhibitor Library Screening Identifies the Cancer Therapeutic Sorafenib and Structurally Similar Compounds as Strong Inhibitors of the Fungal Pathogen Histoplasma capsulatum.

Published in:

Antibiotics (2079-6382), 2021, v. 10, n. 10, p. 1223, doi. 10.3390/antibiotics10101223

By:

Berkes, Charlotte;
Franco, Jimmy;
Lawson, Maxx;
Brann, Katelynn;
Mermelstein, Jessica;
Laverty, Daniel;
Connors, Allison

Publication type:

Article

New Antimicrobial Bioactivity against Multidrug-Resistant Gram-Positive Bacteria of Kinase Inhibitor IMD0354.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 10, p. 665, doi. 10.3390/antibiotics9100665

By:

Escobar, Iliana E;
White, Alexis;
Kim, Wooseong;
Mylonakis, Eleftherios

Publication type:

Article

The Real-World Study of Immunogenicity and Safety of the Adjuvant Recombinant Vaccine against Varicella Zoster Virus in Patients with Immune-Mediated Inflammatory Diseases Treated with Janus Kinase Inhibitors.

Published in:

Vaccines, 2023, v. 11, n. 10, p. 1610, doi. 10.3390/vaccines11101610

By:

Esteban-Vazquez, Ana;
Steiner, Martina;
Castañeda, Elisabet;
Andreu-Vazquez, Cristina;
Thiussard, Israel J.;
Somodevilla, Angela;
Gracia-Martínez, Moisés;
Sánchez-Diaz, Rosa;
García-Yubero, Cristina;
Paredes-Romero, Maria Beatriz;
Munoz-Fernández, Santiago

Publication type:

Article