Works matching AU Kobuchi, Shinji

Results: 28

A validated LC-MS/MS method for the determination of canagliflozin, a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, in a lower volume of rat plasma: application to pharmacokinetic studies in rats.

Published in:

Biomedical Chromatography, 2016, v. 30, n. 10, p. 1549, doi. 10.1002/bmc.3720

By:

Kobuchi, Shinji;
Yano, Kyoka;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

Pharmacokinetics of clomipramine, an antidepressant, in poloxamer 407-induced hyperlipidaemic model rats.

Published in:

Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 4, p. 515, doi. 10.1111/j.2042-7158.2010.01245.x

By:

Kobuchi, Shinji;
Fukushima, Keizo;
Shibata, Masakazu;
Ito, Yukako;
Sugioka, Nobuyuki;
Takada, Kanji

Publication type:

Article

Pharmacokinetics and distribution of fluvoxamine to the brain in rats under oxidative stress.

Published in:

Free Radical Research, 2012, v. 46, n. 7, p. 831, doi. 10.3109/10715762.2012.683430

By:

Kobuchi, Shinji;
Fukushima, Keizo;
Ito, Yukako;
Sugioka, Nobuyuki;
Takada, Kanji

Publication type:

Article

Mobilization of Circulating Tumor Cells after Short- and Long-Term FOLFIRINOX and GEM/nab-PTX Chemotherapy in Xenograft Mouse Models of Human Pancreatic Cancer.

Published in:

Cancers, 2023, v. 15, n. 22, p. 5482, doi. 10.3390/cancers15225482

By:

Ito, Yukako;
Kobuchi, Shinji;
Kawakita, Amiri;
Tosaka, Kazuki;
Matsunaga, Yume;
Yoshioka, Shoma;
Jonan, Shizuka;
Amagase, Kikuko;
Hashimoto, Katsunori;
Kanda, Mitsuro;
Saito, Takuya;
Nakanishi, Hayao

Publication type:

Article

Population Pharmacokinetic Model-Based Evaluation of Intact Oxaliplatin in Rats with Acute Kidney Injury.

Published in:

Cancers, 2021, v. 13, n. 24, p. 6382, doi. 10.3390/cancers13246382

By:

Kobuchi, Shinji;
Kai, Miyu;
Ito, Yukako

Publication type:

Article

Decrease in Brain Distribution of Fluvoxamine in Experimental Hyperlipidemic Rats.

Published in:

Journal of Pharmacy & Pharmaceutical Sciences, 2011, v. 14, n. 3, p. 414, doi. 10.18433/j3vg6t

By:

Fukushima, Keizo;
Kobuchi, Shinji;
Shibata, Masakazu;
Takada, Kanji;
Sugioka, Nobuyuki

Publication type:

Article

Decrease in brain distribution of fluvoxamine in experimental hyperlipidemic rats.

Published in:

2011

By:

Fukushima, Keizo;
Kobuchi, Shinji;
Shibata, Masakazu;
Takada, Kanji;
Sugioka, Nobuyuki

Publication type:

journal article

Association between circadian and chemotherapeutic cycle effects on plasma concentration of 5-fluorouracil and the clinical outcome following definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in patients with esophageal squamous cell carcinoma.

Published in:

Oncology Letters, 2019, v. 17, n. 1, p. 668

By:

Kuwahara, Akiko;
Kobuchi, Shinji;
Tamura, Takao

Publication type:

Article

Translational PK-PD/TD modeling of antitumor effects and peripheral neuropathy in gemcitabine and nab-paclitaxel chemotherapy from xenograft mice to patients for optimal dose and schedule.

Published in:

Cancer Chemotherapy & Pharmacology, 2024, v. 93, n. 4, p. 365, doi. 10.1007/s00280-023-04625-5

By:

Kobuchi, Shinji;
Morita, Atsuko;
Jonan, Shizuka;
Amagase, Kikuko;
Ito, Yukako

Publication type:

Article

Assessment of pharmacokinetic variations of capecitabine after multiple administration in rats: a physiologically based pharmacokinetic model.

Published in:

2020

By:

Sakai, Shuhei;
Kobuchi, Shinji;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

journal article

Pharmacokinetic and toxicodynamic evaluation of oxaliplatin-induced neuropathy and hematological toxicity in rats.

Published in:

2018

By:

Ito, Yukako;
Kobuchi, Shinji;
Shimizu, Risa;
Katsuyama, Yosuke

Publication type:

journal article

Effects of a bolus injection of 5-fluorouracil on dihydropyrimidine dehydrogenase activity in rats receiving continuous infusion of 5-fluorouracil.

Published in:

2016

By:

Kobuchi, Shinji;
Hayashi, Asuka;
Taniguchi, Mayu;
Ito, Yukako;
Tamura, Takao;
Sakaeda, Toshiyuki

Publication type:

journal article

Population pharmacokinetics of afatinib and exposure-safety relationships in Japanese patients with EGFR mutation-positive non-small cell lung cancer.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-54804-9

By:

Nakao, Keiko;
Kobuchi, Shinji;
Marutani, Shuhei;
Iwazaki, Ayano;
Tamiya, Akihiro;
Isa, Shunichi;
Okishio, Kyoichi;
Kanazu, Masaki;
Tamiya, Motohiro;
Hirashima, Tomonori;
Imai, Kimie;
Sakaeda, Toshiyuki;
Atagi, Shinji

Publication type:

Article

Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity.

Published in:

Biopharmaceutics & Drug Disposition, 2019, v. 40, n. 1, p. 44, doi. 10.1002/bdd.2168

By:

Kobuchi, Shinji;
Akutagawa, Mako;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer.

Published in:

Biopharmaceutics & Drug Disposition, 2013, v. 34, n. 7, p. 365, doi. 10.1002/bdd.1851

By:

Kobuchi, Shinji;
Kuwano, Shota;
Imoto, Kazuki;
Okada, Kae;
Nishimura, Asako;
Ito, Yukako;
Shibata, Nobuhito;
Takada, Kanji

Publication type:

Article

Semi-Mechanism-Based Pharmacokinetic-Toxicodynamic Model of Oxaliplatin-Induced Acute and Chronic Neuropathy.

Published in:

Pharmaceutics, 2020, v. 12, n. 2, p. 125, doi. 10.3390/pharmaceutics12020125

By:

Kobuchi, Shinji;
Shimizu, Risa;
Ito, Yukako

Publication type:

Article

Associations of Plasma Concentration Profiles of Dapagliflozin, a Selective Inhibitor of Sodium–Glucose Co-Transporter Type 2, with Its Effects in Japanese Patients with Type 2 Diabetes Mellitus.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 2, p. 203, doi. 10.3390/ph15020203

By:

Hayakawa, Tetsuo;
Kato, Ken-Ichiro;
Kobuchi, Shinji;
Kataoka, Kaede;
Sakaeda, Toshiyuki

Publication type:

Article

Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue.

Published in:

Journal of Drug Targeting, 2017, v. 25, n. 5, p. 420, doi. 10.1080/1061186X.2016.1266650

By:

Ito, Yukako;
Kobuchi, Shinji;
Inoue, Genta;
Kakumu, Eisaku;
Aoki, Miki;
Sakaeda, Toshiyuki;
Takada, Kanji

Publication type:

Article

Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin.

Published in:

Antibiotics (2079-6382), 2020, v. 9, n. 4, p. 199, doi. 10.3390/antibiotics9040199

By:

Kobuchi, Shinji;
Kabata, Teruhiko;
Maeda, Koki;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

Data Mining of the FDA Adverse Event Reporting System and Animal Experiments for Assessment of Rhabdomyolysis Risk Associated with Lipid-lowering Drugs.

Published in:

International Journal of Medical Sciences, 2025, v. 22, n. 7, p. 1485, doi. 10.7150/ijms.109034

By:

Shinji Kobuchi;
Daisuke Sugiyama;
Anna Iima;
Ami Obuchi;
Ayumi Osaka;
Ayana Doi;
Hikaru Ueta;
Satoshi Yokoyama;
Kouichi Hosomi;
Mitsutaka Takada;
Toshiyuki Sakaeda

Publication type:

Article

Pharmacokinetic evaluation of oxaliplatin combined with S-1 (SOX) chemotherapy in a rat model of colorectal cancer with acute kidney injury: predictive renal biomarkers for dose optimisation.

Published in:

Xenobiotica, 2023, v. 53, n. 10/11, p. 613, doi. 10.1080/00498254.2023.2283736

By:

Tanaka, Takumi;
Kobuchi, Shinji;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats.

Published in:

Xenobiotica, 2022, v. 52, n. 7, p. 697, doi. 10.1080/00498254.2022.2142696

By:

Kobuchi, Shinji;
Matsui, Megumi;
Ito, Yukako

Publication type:

Article

Comparing the pharmacokinetics and organ/tissue distribution of anti-methicillin-resistant Staphylococcus aureus agents using a rat model of sepsis.

Published in:

Xenobiotica, 2022, v. 52, n. 6, p. 583, doi. 10.1080/00498254.2022.2098201

By:

Kobuchi, Shinji;
Kanda, Naoya;
Okumi, Taichi;
Kano, Yuma;
Tachi, Himawari;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats.

Published in:

Xenobiotica, 2020, v. 50, n. 5, p. 552, doi. 10.1080/00498254.2019.1654633

By:

Kobuchi, Shinji;
Fujita, Akihiro;
Kato, Akihito;
Kobayashi, Hiromu;
Ito, Yukako;
Sakaeda, Toshiyuki

Publication type:

Article

Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats.

Published in:

Xenobiotica, 2020, v. 50, n. 2, p. 223, doi. 10.1080/00498254.2019.1601790

By:

Kobuchi, Shinji;
Katsuyama, Yosuke;
Ito, Yukako

Publication type:

Article

Population pharmacokinetic modelling and simulation of 5-fluorouracil incorporating a circadian rhythm in rats.

Published in:

Xenobiotica, 2016, v. 46, n. 7, p. 597, doi. 10.3109/00498254.2015.1100767

By:

Kobuchi, Shinji;
Ito, Yukako;
Nakano, Yuya;
Sakaeda, Toshiyuki

Publication type:

Article

Semi-physiological pharmacokinetic-pharmacodynamic (PK-PD) modeling and simulation of 5-fluorouracil for thrombocytopenia in rats.

Published in:

Xenobiotica, 2015, v. 45, n. 1, p. 19, doi. 10.3109/00498254.2014.943335

By:

Kobuchi, Shinji;
Ito, Yukako;
Hayakawa, Taro;
Nishimura, Asako;
Shibata, Nobuhito;
Takada, Kanji;
Sakaeda, Toshiyuki

Publication type:

Article

Semi-physiological pharmacokinetic-pharmacodynamic modeling and simulation of 5-fluorouracil for the whole time course of alterations in leukocyte, neutrophil and lymphocyte counts in rats.

Published in:

Xenobiotica, 2014, v. 44, n. 9, p. 804, doi. 10.3109/00498254.2014.900588

By:

Kobuchi, Shinji;
Ito, Yukako;
Hayakawa, Taro;
Kuwano, Shota;
Baba, Akiko;
Shinohara, Kota;
Nishimura, Asako;
Shibata, Nobuhito;
Takada, Kanji

Publication type:

Article