Chlorogenic Acid Plays an Important Role in Improving the Growth and Antioxidant Status and Weakening the Inflammatory Response of Largemouth Bass (Micropterus salmoides).

Xia, Zetian; Mi, Haifeng; Ren, Mingchun; Huang, Dongyu; Aboseif, Ahmed Mohamed; Liang, Hualiang; Zhang, Lu

Simple Summary: This study examined the effects of chlorogenic acid (CGA) on largemouth bass's growth, immunity, and antioxidant status. Over eight weeks, fish were fed diets with varying CGA levels. In this study, CGA improved the growth performance and lowered the FCR. In addition, CGA enhanced the antioxidant capacity and regulated the expression of genes related to immune responses, thereby strengthening immunity. Overall, the addition of CGA positively impacted the health and growth of largemouth bass. This experiment evaluated the function of chlorogenic acid (CGA) in the growth, health status, and inflammation of largemouth bass (Micropterus salmoides). Over eight weeks, CGA supplementation was designed at five levels: 0, 60, 120, 180, and 240 mg/kg. The 180 and 240 mg/kg CGA-supplemented groups showed significant improvements in the FBW, SGR, and WGR compared to the control group (0 mg/kg) (p 0.05). Compared to the control group, the 180 mg/kg CGA group exhibited significantly lower TC and TG levels (p 0.05). In terms of antioxidant parameters, CGA supplementation considerably reduced the MDA content (p < 0.05) and increased the GSH levels, while decreasing the CAT, SOD, and GPx activity levels Meanwhile, CGA supplementation resulted in reduced mRNA levels of SOD, CAT, Nrf2, Keap1, and NF-κB compared to the control group. In contrast, the mRNA levels of GPx, IL-8, TLR2, and RelA were elevated in the liver. Our findings indicated that CGA supplementation improved the growth performance and antioxidant status and weakened the inflammatory response of largemouth bass. These findings suggest that CGA could be a valuable dietary supplement for enhancing the health and growth of this species.

CHLOROGENIC acid; OXIDANT status; FEED additives; DIETARY supplements; GENE expression

Animals (2076-2615), 2024, Vol 14, Issue 19, p2871

2076-2615

Academic Journal

10.3390/ani14192871