Cheese production generates a large amount of liquid waste called cheese whey (CW). The management of CW is not optimized in Ecuador since a large proportion of it is discharged into the soil or effluents, causing significant environmental impacts. For this reason, the co-composting of whey with solid organic wastes can be a suitable method for its treatment for small companies generating this liquid waste due to its effectiveness and low cost. In this study, we analyzed 10 CW samples from different small companies in the Mocha canton (Tungurahua, Ecuador) to determine specific physicochemical and chemical parameters. Subsequently, a waste pile was formed with crop residues (corn and beans) and cow manure, which was composted using the turned pile composting system. Throughout the composting process, the temperature of the pile was controlled, its moisture was maintained between 40 and 60% by adding whey, and several physicochemical, chemical, and biological properties were determined. The results showed that the CW presented a high organic load, notable macronutrient content, and low heavy metal concentrations, all of which are beneficial for its co-composting with other organic solid wastes. The only limiting factors involved in using large amounts of whey in the composting process were the low pH values of the acid CW and the high concentrations of salts. It was also observed that co-composting CW with agro-livestock wastes was a viable strategy to treat these wastes and produce compost with stabilized and humified organic matter and remarkable agricultural value.