Growth Hormone as a Potential Mediator of Aerobic Exercise-Induced Reductions in Visceral Adipose Tissue.

Sabag, Angelo; Chang, Dennis; Johnson, Nathan A.

Importantly, not all adult GH deficiency is caused by obesity-inducing behaviors, as adults with hypothalamic or pituitary diseases also exhibit suppressed GH production and increased central adiposity. GH is secreted at the anterior pituitary gland in a pulsatile manner and is primarily regulated by hypothalamic neuropeptides GH-releasing hormone (GHRH) and somatostatin, which stimulate and inhibit GH secretion, respectively (Vijayakumar et al., [52]). Keywords: growth hormone; cardiometabolic health; abdominal adipose tissue; cardiorespiratory fitness; obesity; aging EN growth hormone cardiometabolic health abdominal adipose tissue cardiorespiratory fitness obesity aging N.PAG N.PAG 6 04/29/21 20210426 NES 210426 Introduction Obesity remains one of the leading causes of death worldwide and is a well-known risk factor for a myriad of non-communicable diseases including diabetes, cardiovascular disease, and a variety of cancers (Wolf and Colditz, [54]; Frühbeck et al., [9]). The decreased growth hormone response to growth hormone releasing hormone in obesity is associated to cardiometabolic risk factors.

ADIPOSE tissues; SOMATOTROPIN; TYPE 2 diabetes; PITUITARY dwarfism; SOMATOMEDIN; STEROL regulatory element-binding proteins; GROWTH hormone releasing factor; EXERCISE physiology

Frontiers in Physiology, 2021, Vol 11, pN.PAG

1664-042X

Academic Journal

10.3389/fphys.2021.623570