EBSCO Logo
Connecting you to content on EBSCOhost
Results
Title

Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations.

Authors

Pandey, Pratibha; Lakhanpal, Sorabh; Mahmood, Danish; Kang, Han Na; Kim, Byunggyu; Kang, Sojin; Choi, Jinwon; Moon, Seungjoon; Pandey, Shivam; Ballal, Suhas; Kumar, Sanjay; Khan, Fahad; Kim, Bonglee

Abstract

The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug discovery and development. Bergenin, a naturally occurring secondary metabolite, has been extracted from several plant components. It is a constituent found in herbal and Ayurvedic preparations. It demonstrates antiviral, antifungal, antitussive, antiplasmodial, anti-inflammatory, antihepatotoxic, antiarrhythmic, antitumor, antiulcerogenic, antidiabetic, and wound healing activities. Bergenin efficiently inhibited the proliferation of human cancer cells by stimulating the production of intracellular reactive oxygen species (ROS), causing DNA damage and leading to cell cycle arrest in the G1/G2 phases by blocking cell signaling pathways. More comprehensive reviews are needed on the anticancer properties of bergenin. Therefore, our review aimed to update the multifaceted benefits of bergenin to the future scientists and researchers, which can be leveraged to formulate safer and novel cancer therapies, while also establishing a robust framework for future investigations into bergenin in cancer treatment. More preclinical and clinical investigations are needed to validate the candidature of bergenin as a potent anticancer agent.

Subjects

DRUG discovery; CANCER cell proliferation; REACTIVE oxygen species; CELL cycle; CELL communication

Publication

Frontiers in Pharmacology, 2025, p1

ISSN

1663-9812

Publication type

Academic Journal

DOI

10.3389/fphar.2024.1481587

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved