Works matching DE "LIVER microsomes"

Results: 701

Genotoxic Herbicide Exposures in Golden Retrievers With and Without Multicentric Lymphoma.

Published in:

Veterinary & Comparative Oncology, 2025, v. 23, n. 2, p. 246, doi. 10.1111/vco.13051

By:

Tindle, Ashleigh N.;
Krueger, Lauren M.;
Swafford, Brenna;
Mani, Erin;
Danielson, Camille;
Labadie, Julia;
Trepanier, Lauren A.

Publication type:

Article

Metabolic activation and cytotoxicity of ibudilast mediated by CYP3A4.

Published in:

Archives of Toxicology, 2025, v. 99, n. 5, p. 2023, doi. 10.1007/s00204-025-03995-4

By:

Dong, Lingwen;
Hao, Xialing;
Liu, Minglu;
Zhai, Yanjie;
Wang, Xu;
Tian, Xiaobao;
Li, Weiwei;
Peng, Ying;
Zheng, Jiang

Publication type:

Article

Stereoselectivity of In Vivo Processes and Bioactivity of Farrerol Enantiomers.

Published in:

Molecules, 2025, v. 30, n. 9, p. 2038, doi. 10.3390/molecules30092038

By:

Chen, Lirong;
Yan, Tang;
Huang, Dongting;
Xu, Wei;
Liu, Yongjing;
Wang, Xiaoying;
Li, Hua

Publication type:

Article

Impact of CYP3A4 functional variability on ziprasidone metabolism.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1585040

By:

Zhou, Qi;
Wu, Yameng;
Ye, Zhize;
Zhang, Zheyan;
Zheng, Kai;
Qian, Jianchang;
Xiao, Zhongxiang;
Lu, Yang

Publication type:

Article

An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts.

Published in:

Journal of Environmental Science & Health. Part C. Toxicology & Carcinogenesis, 2025, v. 43, n. 2, p. 117, doi. 10.1080/26896583.2024.2424091

By:

He, Xiaobo;
Xia, Qingsu;
Bryant, Matthew S.;
Fu, Peter P.

Publication type:

Article

Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women.

Published in:

Analytical & Bioanalytical Chemistry, 2025, v. 417, n. 13, p. 2823, doi. 10.1007/s00216-024-05430-6

By:

Li, Wei;
Gong, Xingcheng;
Niu, Xiaoya;
Zhou, Yuxuan;
Ren, Luyao;
Man, Zhuo;
Tu, Pengfei;
Xiong, Xin;
Liu, Wenjing;
Song, Yuelin

Publication type:

Article

Inhibitory effect of carvedilol on bedaquiline metabolism in vitro and in vivo.

Published in:

PeerJ, 2025, p. 1, doi. 10.7717/peerj.19313

By:

Li, Qingqing;
Li, Wanshu;
Chen, Jie;
Lin, Hangjuan;
Zhou, Cixia

Publication type:

Article

Does ketamine show tolerance?

Published in:

2023

By:

Bharadwaj, Abhishek

Publication type:

Case Study

Metabolism‑mediated interaction potential of standardized extract of Tinospora cordifolia through rat and human liver microsomes.

Published in:

Indian Journal of Pharmacology, 2016, v. 48, n. 5, p. 576, doi. 10.4103/0253-7613.190758

By:

Bahadur, Shiv;
Mukherjee, Pulok K.;
Ahmmed, S. K. Milan;
Kar, Amit;
Harwansh, Ranjit K.;
Pandit, Subrata

Publication type:

Article

Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones.

Published in:

Bulletin of Experimental Biology & Medicine, 2021, v. 172, n. 2, p. 133, doi. 10.1007/s10517-021-05349-3

By:

Tursunova, N. V.;
Syrov, V. N.;
Khushbaktova, Z. A.;
Tornuev, Yu. V.;
Klinnikova, M. G.

Publication type:

Article

Metabolism of a New Antiaggregant, Indolinone Derivative.

Published in:

Bulletin of Experimental Biology & Medicine, 2020, v. 168, n. 6, p. 739, doi. 10.1007/s10517-020-04792-y

By:

Bykov, V. V.;
Leonov, K. A.;
Serebrov, V. Yu.;
Chernysheva, G. A.;
Smol'yakova, V. I.;
Solov'ev, M. A.;
Udut, E. V.;
Fisenko, V. P.;
Udut, V. V.

Publication type:

Article

In vitro metabolic characterization of orbitazine, a novel derivative of the PAC-1 anticancer agent.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 11, p. 1199, doi. 10.1111/jphp.13296

By:

Fang Li;
Xuhua Han;
Yanfen Chen;
Shanshan Wang;
Zeneng Cheng;
Gaoyun Hu;
Wenjie Liu;
Qubo Zhu

Publication type:

Article

Chronotoxicity of Semen Strychni is associated with circadian metabolism and transport in mice.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 3, p. 398, doi. 10.1093/jpp/rgaa007

By:

Lu Gao;
Yanke Lin;
Shuai Wang;
Luomin Lin;
Danyi Lu;
Yue Zhao;
Huijie Xing;
Baojian Wu

Publication type:

Article

Identification of human uridine diphosphateglucuronosyltransferase isoforms responsible for the glucuronidation of 10,11-dihydro-10-hydroxy-carbazepine.

Published in:

Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 3, p. 388, doi. 10.1093/jpp/rgaa059

By:

Kai Huang;
Linling Que;
Ying Ding;
Nannan Chu;
Zhenzhong Qian;
Wei Qin;
Yuanxing Chen;
Jisheng Zhang;
Qing He

Publication type:

Article

Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu‐gu‐zhi) and its potential inhibition against human cytochrome P450s and UDP‐glucuronosyltransferases.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 12, p. 1865, doi. 10.1111/jphp.13337

By:

Xing, Han;
Yang, Jing;
Ren, Kaidi;
Qin, Zifei;
Wang, Peile;
Zhang, Xiaojian;
Yao, Zhihong;
Gonzalez, Frank J.;
Yao, Xinsheng

Publication type:

Article

Characterization of metabolic activity, isozyme contribution and species differences of bavachin, and identification of efflux transporters for bavachin‐O‐glucuronide in HeLa1A1 cells.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 12, p. 1771, doi. 10.1111/jphp.13324

By:

Li, Yang;
Xu, Chunxia;
Xu, Jinjin;
Qin, Zifei;
Li, Shishi;
Hu, Liufang;
Yao, Zhihong;
Gonzalez, Frank J.;
Yao, Xinsheng

Publication type:

Article

The effect of apatinib on pharmacokinetic profile of buspirone both in vivo and in vitro.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 10, p. 1405, doi. 10.1111/jphp.13320

By:

Zhang, Xiao‐dan;
Li, Ying‐hui;
Chen, Dao‐xing;
You, Wei‐wei;
Hu, Xiao‐xia;
Chen, Bing‐bing;
Hu, Guo‐xin;
Qian, Jian‐chang

Publication type:

Article

In vitro metabolic characterization of orbitazine, a novel derivative of the PAC‐1 anticancer agent.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 9, p. 1199, doi. 10.1111/jphp.13296

By:

Li, Fang;
Han, Xuhua;
Chen, Yanfen;
Wang, Shanshan;
Cheng, Zeneng;
Hu, Gaoyun;
Liu, Wenjie;
Zhu, Qubo

Publication type:

Article

Pharmacokinetic interaction between a Chinese herbal formula Huosu Yangwei oral liquid and apatinib in vitro and in vivo.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 7, p. 979, doi. 10.1111/jphp.13268

By:

Fang, Sheng‐Quan;
Huang, Jian;
Zhang, Feng;
Ni, Hong‐Mei;
Chen, Qi‐Long;
Zhu, Jun‐Ran;
Fu, Zhi‐Chao;
Zhu, Liang;
Hao, Wei‐Wei;
Ge, Guang‐Bo

Publication type:

Article

Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 12, p. 1673, doi. 10.1111/jphp.12483

By:

Xin, Hong;
Xia, Yang‐Liu;
Hou, Jie;
Wang, Ping;
He, Wei;
Yang, Ling;
Ge, Guang‐Bo;
Xu, Wei

Publication type:

Article

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1 A9 and UGT2 B7.

Published in:

Journal of Pharmacy & Pharmacology, 2015, v. 67, n. 4, p. 583, doi. 10.1111/jphp.12351

By:

Wu, Zhufeng;
Liu, Hongming;
Wu, Baojian

Publication type:

Article

In Vitro and In Vivo Effect of Xylopic Acid on Cytochrome P450 Enzymes.

Published in:

Advances in Pharmacological & Pharmaceutical Sciences, 2022, p. 1, doi. 10.1155/2022/4524877

By:

Agbenyeku, Mary A.;
Appiah-Opong, Regina;
Obese, Ernest;
Biney, Robert P.;
Adakudugu, Emmanuel A.;
Forkuo, Arnold D.;
Osei, Silas A.;
Abeka, Mustapha K.;
Ameyaw, Elvis O.

Publication type:

Article

Identification and Characterization of in vitro Metabolites of Belinostat by Rat Liver Microsomes using Ultra Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry.

Published in:

Indian Journal of Pharmaceutical Education & Research, 2022, v. 56, p. 58, doi. 10.5530/ijper.56.1s.43

By:

Grover, Parul;
Mehta, Lovekesh;
Naved, Tanveer;
Kumar, Sandeep;
Monga, Gorav

Publication type:

Article

QUANTITATIVE STRUCTURE-HEPATOTOXICITY ASSESSMENT OF SERIES ARYLPIPERAZINE-N¹-SUBSTITUTED THEOBROMINE DERIVATIVES.

Published in:

Farmacia, 2020, v. 68, n. 1, p. 56, doi. 10.31925/farmacia.2020.1.9

By:

KONDEVA-BURDINA, MAGDALENA;
VALKOVA, IVA;
ANDONOVA, LILY;
GEORGIEVA, MAYA;
TZANKOVA, VIRGINIA;
ZLATKOV, ALEXANDER

Publication type:

Article

Partial purification of somatotropin receptors from pig liver: they arise from a single somatotropin receptor messenger RNA transcript.

Published in:: Journal of Animal Science, 1992, v. 70, n. 11, p. 3421, doi. 10.2527/1992.70113421x
Publication type:: Article

氯丙嗪在不同种属肝微粒体中代谢差异研究.

Published in:

Journal of Chinese Mass Spectrometry Society, 2022, v. 43, n. 3, p. 357, doi. 10.7538/zpxb.2021.0142

By:

董凡;
谭叙;
何欣;
谢晴;
谭峰

Publication type:

Article

4′-氯地西泮和二氯西泮的大鼠肝微粒体体外代谢研究.

Published in:

Journal of Chinese Mass Spectrometry Society, 2022, v. 43, n. 1, p. 34, doi. 10.7538/zpxb.2020.0134

By:

李乐;
赵君博;
严慧;
邓虹霄;
范先煜;
刘万卉;
向平

Publication type:

Article

The Systematic Assessment of the Membrane-Stabilizing and Antioxidant Activities of Several Kazakhstani Plants in the Asteraceae Family.

Published in:

Plants (2223-7747), 2024, v. 13, n. 1, p. 96, doi. 10.3390/plants13010096

By:

Ydyrys, Alibek;
Zhamanbayeva, Gulzhan;
Zhaparkulova, Nazgul;
Aralbaeva, Arailym;
Askerbay, Gulnaz;
Kenzheyeva, Zhanar;
Tussupbekova, Gulmira;
Syraiyl, Sayagul;
Kaparbay, Raushan;
Murzakhmetova, Maira

Publication type:

Article

Inhibition of the CYP Enzymatic System Responsible of Heterocyclic Amines Bioactivation by an Asclepias subulata Extract.

Published in:

Plants (2223-7747), 2023, v. 12, n. 12, p. 2354, doi. 10.3390/plants12122354

By:

Gutiérrez-Pacheco, Samaria Lisdeth;
Peña-Ramos, Etna Aida;
Santes-Palacios, Rebeca;
Valenzuela-Melendres, Martin;
Hernández-Mendoza, Adrián;
Burgos-Hernández, Armando;
Robles-Zepeda, Ramón Enrique;
Espinosa-Aguirre, Jesús Javier

Publication type:

Article

Successful xenotransplantation with re-aggregated and encapsulated neonatal pig liver cells for treatment of mice with acute liver failure.

Published in:

Xenotransplantation, 2015, v. 22, n. 4, p. 249, doi. 10.1111/xen.12177

By:

Ham, Dong‐Sik;
Song, Min‐Sang;
Park, Heon‐Seok;
Rhee, Marie;
Yang, Hae Kyung;
Lee, Seung‐Hwan;
Kim, Ji‐Won;
Jung, Eun‐Sun;
Yoon, Kun‐Ho

Publication type:

Article

Anti-methicillin-resistant Staphylococcus aureus activity and safety evaluation of 14-O-[(5-ethoxycarbonyl-4,6-dimethylpyrimidine-2-yl) thioacetyl] mutilin (EDT).

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-42621-0

By:

Zhou, Yuhang;
Yi, Yunpeng;
Yang, Jing;
Zhang, Hongjuan;
Liu, Qinqin;
Wang, Shengyi;
Pu, Wanxia;
Shang, Ruofeng

Publication type:

Article

Effect of P. corylifolia on the pharmacokinetic profile of tofacitinib and the underlying mechanism.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1351882

By:

Yu Wang;
Quan Zhou;
Huihui Wang;
Wei Song;
Jianfeng Wang;
Al Mamun, Abdullah;
Peiwu Geng;
Yunfang Zhou;
Shuanghu Wang

Publication type:

Article

Inhibitory effect of napabucasin on arbidol metabolism and its mechanism research.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1292354

By:

Jingjing Nie;
Hailun Xia;
Ya-Nan Liu;
Yige Yu;
Ren-Ai Xu

Publication type:

Article

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1199548

By:

Yunyun Zhan;
Anzhou Wang;
Yige Yu;
Jie Chen;
Xinhao Xu;
Jingjing Nie;
Jingjing Lin

Publication type:

Article

Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1204649

By:

Jia Xu;
Quan Zhou;
Pengjiao Hou;
Yu Wang;
Peiwu Geng;
Zebei Lu;
Yunfang Zhou;
Dapeng Dai;
Shuanghu Wang

Publication type:

Article

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1207928

By:

Hanxue Wang;
Min Xuan;
Juanjuan Diao;
Nan Xu;
Manlin Li;
Cheng Huang;
Changhong Wang

Publication type:

Article

The impact of CYP2C19 genotype on phenoconversion by concomitant medication.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1201906

By:

de Jong, Laura M.;
Boussallami, Soukayna;
Sánchez-López, Elena;
Giera, Martin;
Tushuizen, Maarten E.;
Hoekstra, Menno;
Hawinkels, Lukas J. A. C.;
Rissmann, Robert;
Swen, Jesse J.;
Manson, Martijn L.

Publication type:

Article

Studies on the inhibitory effect of isavuconazole on flumatinib metabolism in vitro and in vivo.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1168852

By:

Ya-nan Liu;
Xinhao Xu;
Jingjing Nie;
Yingying Hu;
Xuegu Xu;
Ren-ai Xu;
Xiaoxiang Du

Publication type:

Article

Study on the liver Drug's dominant metabolic enzymes for six effective components of the Huang qi Liuyi decoction.

Published in:

Frontiers in Pharmacology, 2023, p. 01, doi. 10.3389/fphar.2023.1175896

By:

Qun Wang;
Tiantian Tang;
Zengguang Wu;
Hong Yang;
Yuan Gao;
Shiyu Zhang;
Xinli Song;
Xiaolan Chen

Publication type:

Article

Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00479

By:

Xiangmeng Wu;
Qinghao Zhang;
Jiamei Guo;
Yufei Jia;
Ziqian Zhang;
Manman Zhao;
Yakun Yang;
Baolian Wang;
Jinping Hu;
Li Sheng;
Yan Li

Publication type:

Article

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00376

By:

Jie Li;
Xin Li;
Yu-Shan Ren;
Yuan-Yuan Lv;
Jun-Sheng Zhang;
Xiao-Li Xu;
Xian-Zhen Wang;
Jing-Chun Yao;
Gui-Min Zhang;
Zhong Liu

Publication type:

Article

In vitro metabolism and inhibitory effects of atractylenolide II on various hepatic CYPs in HLMs.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2021, v. 30, n. 8, p. 645, doi. 10.5246/jcps.2021.08.052

By:

Xulong Chen;
Zhenggen Liao;
Cheng Li;
Guoyong Huang;
Yunyan Song;
Wei Dong;
Abid Naeem;
Xinli Liang

Publication type:

Article

Inhibitory effect of the combination of notoginseng total saponins and safflower total flavonoids on UDP-glucuronosyltransferases 1A1, 1A4, and 2B7 in human liver microsomes.

Published in:

Journal of Chinese Pharmaceutical Sciences, 2019, v. 28, n. 4, p. 229, doi. 10.5246/jcps.2019.04.023

By:

Yan Li;
Yuqing Meng;
Yingyuan Lu;
Kun Chang;
Peng Gao;
Yong Jiang;
Pengfei Tu;
Xiaoyu Guo

Publication type:

Article

Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug–drug interaction potentials.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2021, v. 84, n. 20, p. 821, doi. 10.1080/15287394.2021.1944942

By:

Park, Ria;
Choi, Won-Gu;
Lee, Min Seo;
Cho, Yong-Yeon;
Lee, Joo Young;
Kang, Han Chang;
Sohn, Chang Hwan;
Song, Im-Sook;
Lee, Hye Suk

Publication type:

Article

Comprehensive characterization of narirutin metabolites in vitro and in vivo based on Analogous-Core recursion analysis strategy using UHPLC-Q-Exactive Orbitrap MS/MS.

Published in:

Arabian Journal of Chemistry, 2023, v. 16, n. 8, p. N.PAG, doi. 10.1016/j.arabjc.2023.104949

By:

Song, Shuyi;
Zhou, Hongyan;
Lan, Xianming;
Yuan, Xiaoqing;
Li, Yanan;
Huang, Shuteng;
Wang, Zhibin;
Zhang, Jiayu

Publication type:

Article

Inhibitory effect of propafenone on vortioxetine metabolism in vitro and in vivo.

Published in:

Arabian Journal of Chemistry, 2021, v. 14, n. 5, p. N.PAG, doi. 10.1016/j.arabjc.2021.103136

By:

Xu, Ren-ai;
Luo, Shunbin;
Lin, Qianmeng;
Shao, Yuanyuan;
Chen, Chaojie;
Ye, Xuemei

Publication type:

Article

Comprehensive Profiling And Quantification Of Novel Antidiabetic Pharmaceuticals (Dapagliflozin And Saxagliptin): An Integrated Approach Utilizing Liquid Chromatography-Mass Spectrometry (LC-MS) For Structural Elucidation, Metabolic Pathway Identification, And Bioavailability Assessment.

Published in:

Eurasian Journal of Analytical Chemistry, 2024, v. 19, n. 1, p. 267

By:

Navale, Sampat Dnyaneshwar;
Borkar, Sudarshan Nandkumar;
Sopanrao, Dengale Santosh;
Dhambore, Bhagyashree R.;
Baban, Datir Mahendra;
Rajaram, Nehe Ashwini

Publication type:

Article

An Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation.

Published in:

Medicina (1010660X), 2024, v. 60, n. 12, p. 1914, doi. 10.3390/medicina60121914

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

An Ultra-Fast Green UHPLC-MS/MS Method for Assessing the In Vitro Metabolic Stability of Dovitinib: In Silico Study for Absorption, Distribution, Metabolism, Excretion, Metabolic Lability, and DEREK Alerts.

Published in:

Medicina (1010660X), 2024, v. 60, n. 10, p. 1626, doi. 10.3390/medicina60101626

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.

Published in:

Biological Chemistry, 2023, v. 404, n. 4, p. 255, doi. 10.1515/hsz-2022-0229

By:

Bechthold, Elena;
Grey, Lucie;
Diamant, Emil;
Schmidt, Judith;
Steigerwald, Ruben;
Zhao, Fabao;
Hansen, Kasper B.;
Bunch, Lennart;
Clausen, Rasmus P.;
Wünsch, Bernhard

Publication type:

Article