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Making hydroxyurea affordable for sickle cell disease in Tanzania is essential (HASTE): How to meet major health needs at a reasonable cost.
Published in:
American Journal of Hematology, 2021, v. 96, n. 1, p. E2, doi. 10.1002/ajh.26007
By:
- Costa, Enrico;
- Tibalinda, Prosper;
- Sterzi, Enrico;
- Leufkens, Hubert M. G.;
- Makani, Julie;
- Kaale, Eliangiringa;
- Luzzatto, Lucio
Publication type:
Article
Uptake of orphan drugs in the WHO essential medicines lists.
Published in:
Bulletin of the World Health Organization, 2024, v. 102, n. 1, p. 22, doi. 10.2471/BLT.23.289731
By:
- Costa, Enrico;
- Moja, Lorenzo;
- Wirtz, Veronika J.;
- van den Ham, Hendrika A.;
- Huttner, Benedikt;
- Magrini, Nicola;
- Leufkens, Hubert G. M.
Publication type:
Article
Effect of the economic recession on pharmaceutical policy and medicine sales in eight European countries.
Published in:
Bulletin of the World Health Organization, 2014, v. 92, n. 9, p. 630, doi. 10.2471/BLT.13.129114
By:
- Leopold, Christine;
- Mantel-Teeuwisse, Aukje K.;
- Vogler, Sabine;
- Valkova, Silvia;
- de Joncheere, Kees;
- Leufkens, Hubert G. M.;
- Wagner, Anita K.;
- Ross-Degnan, Dennis;
- Laing, Richard
Publication type:
Article
Global strategies to reduce the price of antiretroviral medicines: evidence from transactional databases.
Published in:
Bulletin of the World Health Organization, 2009, v. 87, n. 7, p. 520, doi. 10.2471/BLT.08.058925
By:
- Waning, Brenda;
- Kaplan, Warren;
- King, Alexis C.;
- Lawrence, Danielle A.;
- Leufkens, Hubert G.;
- Fox, Matthew P.
Publication type:
Article
Risk of fracture with thiazolidinediones: an individual patient data meta-analysis.
Published in:
Frontiers in Endocrinology, 2013, v. 4, p. 1, doi. 10.3389/fendo.2013.00011
By:
- Bazelier, Marloes T.;
- de Vries, Frank;
- Vestergaard, Peter;
- Herings, Ron M. C.;
- Gallagher, Arlene M.;
- Leufkens, Hubert G. M.;
- van Staa, Tjeerd-Pieter
Publication type:
Article
Non-Publication Is Common among Phase 1, Single-Center, Not Prospectively Registered, or Early Terminated Clinical Drug Trials.
Published in:
PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167709
By:
- van den Bogert, Cornelis A.;
- Souverein, Patrick C.;
- Brekelmans, Cecile T. M.;
- Janssen, Susan W. J.;
- Koëter, Gerard H.;
- Leufkens, Hubert G. M.;
- Bouter, Lex M.
Publication type:
Article
Phase I/II Clinical Trial-Based Early Economic Evaluation of Acalabrutinib for Relapsed Chronic Lymphocytic Leukaemia.
Published in:
Applied Health Economics & Health Policy, 2019, v. 17, n. 6, p. 883, doi. 10.1007/s40258-019-00496-1
By:
- Vreman, Rick A.;
- Geenen, Joost W.;
- Hövels, Anke M.;
- Goettsch, Wim G.;
- Leufkens, Hubert G. M.;
- Al, Maiwenn J.
Publication type:
Article
The Risk of Colorectal Cancer in Patients With Type 2 Diabetes: Associations With Treatment Stage and Obesity.
Published in:
Diabetes Care, 2015, v. 38, n. 3, p. 495, doi. 10.2337/dc14-1175
By:
- Peeters, Paul J. H. L.;
- Bazelier, Marloes T.;
- Leufkens, Hubert G. M.;
- de Vries, Frank;
- De Bruin, Marie L.
Publication type:
Article
Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana.
Published in:
BMC Public Health, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12889-015-1928-6
By:
- Tetteh, Raymond A.;
- Nartey, Edmund T.;
- Lartey, Margaret;
- Mantel-Teeuwisse, Aukje K.;
- Leufkens, Hubert G. M.;
- Nortey, Priscilla A.;
- Dodoo, Alexander N. O.
Publication type:
Article
Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana.
Published in:
BMC Public Health, 2015, v. 15, n. 1, p. 573, doi. 10.1186/s12889-015-1928-6
By:
- Tetteh, Raymond A.;
- Nartey, Edmund T.;
- Lartey, Margaret;
- Mantel-Teeuwisse, Aukje K.;
- Leufkens, Hubert G. M.;
- Nortey, Priscilla A.;
- Dodoo, Alexander N. O.
Publication type:
Article
Comparing amikacin and kanamycininduced hearing loss in multidrug-resistant tuberculosis treatment under programmatic conditions in a Namibian retrospective cohort.
Published in:
BMC Pharmacology & Toxicology, 2015, v. 16, p. 1, doi. 10.1186/s40360-015-0036-7
By:
- Sagwa, Evans L.;
- Ruswa, Nunurai;
- Mavhunga, Farai;
- Rennie, Timothy;
- Leufkens, Hubert G. M.;
- Mantel-Teeuwisse, Aukje K.
Publication type:
Article
Challenges and Opportunities for Companies to Build HTA/Payer Perspectives Into Drug Development Through the Use of a Dynamic Target Product Profile.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.948161
By:
- Ting Wang;
- McAuslane, Neil;
- Goettsch, Wim G.;
- Leufkens, Hubert G. M.;
- De Bruin, Marie L.
Publication type:
Article
Exploring the Association between Monoclonal Antibodies and Depression and Suicidal Ideation and Behavior: A VigiBase Study.
Published in:
2019
By:
- Minnema, Lotte A.;
- Giezen, Thijs J.;
- Souverein, Patrick C.;
- Egberts, Toine C. G.;
- Leufkens, Hubert G. M.;
- Gardarsdottir, Helga
Publication type:
journal article
Pre-Exposure Prophylaxis for HIV Prevention: Safety Concerns.
Published in:
2017
By:
- Tetteh, Raymond;
- Yankey, Barbara;
- Nartey, Edmund;
- Lartey, Margaret;
- Leufkens, Hubert;
- Dodoo, Alexander;
- Tetteh, Raymond A;
- Yankey, Barbara A;
- Nartey, Edmund T;
- Leufkens, Hubert G M;
- Dodoo, Alexander N O
Publication type:
journal article
Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients.
Published in:
2016
By:
- Tetteh, Raymond;
- Nartey, Edmund;
- Lartey, Margaret;
- Mantel-Teeuwisse, Aukje;
- Leufkens, Hubert;
- Yankey, Barbara;
- Dodoo, Alexander;
- Tetteh, Raymond A;
- Nartey, Edmund T;
- Mantel-Teeuwisse, Aukje K;
- Leufkens, Hubert G M;
- Yankey, Barbara A;
- Dodoo, Alexander N O
Publication type:
journal article
Adverse Drug Reaction Reporting in Africa and a Comparison of Individual Case Safety Report Characteristics Between Africa and the Rest of the World: Analyses of Spontaneous Reports in VigiBase®.
Published in:
2016
By:
- Ampadu, Haggar;
- Hoekman, Jarno;
- Bruin, Marieke;
- Pal, Shanthi;
- Olsson, Sten;
- Sartori, Daniele;
- Leufkens, Hubert;
- Dodoo, Alexander;
- Ampadu, Haggar H;
- de Bruin, Marieke L;
- Pal, Shanthi N;
- Leufkens, Hubert G M;
- Dodoo, Alexander N O
Publication type:
journal article
Incidence of adverse events among healthcare workers following H1N1 Mass immunization in Ghana: a prospective study.
Published in:
2013
By:
- Ankrah, Daniel N A;
- Mantel-Teeuwisse, Aukje K;
- De Bruin, Marie L;
- Amoo, Philip K;
- Ofei-Palm, Charles N;
- Agyepong, Irene;
- Leufkens, Hubert G M
Publication type:
journal article
Reasons for and time to discontinuation of rimonabant therapy: a modified prescription-event monitoring study.
Published in:
2012
By:
- Willemen MJ;
- Mantel-Teeuwisse AK;
- Buggy Y;
- Layton D;
- Straus SM;
- Leufkens HG;
- Egberts TC;
- Willemen, Marjolein J C;
- Mantel-Teeuwisse, Aukje K;
- Buggy, Yvonne;
- Layton, Deborah;
- Straus, Sabine M J M;
- Leufkens, Hubert G M;
- Egberts, Toine C G
Publication type:
journal article
Reasons for and Time to Discontinuation of Rimonabant Therapy A Modified Prescription-Event Monitoring Study.
Published in:
Drug Safety, 2012, v. 35, n. 12, p. 1147, doi. 10.2165/11631330-000000000-00000
By:
- Willemen, Marjolein J. C.;
- Mantel-Teeuwisse, Aukje K.;
- Buggy, Yvonne;
- Layton, Deborah;
- Straus, Sabine M. J. M;
- Leufkens, Hubert G. M.;
- Egberts, Tome C. G.
Publication type:
Article
A cohort study exploring determinants of safety-related regulatory actions for biopharmaceuticals.
Published in:
2012
By:
- Ebbers HC;
- Mantel-Teeuwisse AK;
- Moors EH;
- Sayed Tabatabaei FA;
- Schellekens H;
- Leufkens HG;
- Ebbers, Hans C;
- Mantel-Teeuwisse, Aukje K;
- Moors, Ellen H M;
- Sayed Tabatabaei, Fakhredin A;
- Schellekens, Huub;
- Leufkens, Hubert G M
Publication type:
journal article
Randomized controlled trials of COX-2 inhibitors: an analysis of doses used and trends over time to investigate implications for comparative safety.
Published in:
2011
By:
- Stefansdottir G;
- De Bruin ML;
- Knol MJ;
- Grobbee DE;
- Leufkens HG;
- Stefansdottir, Gudrun;
- De Bruin, Marie L;
- Knol, Mirjam J;
- Grobbee, Diederick E;
- Leufkens, Hubert G M
Publication type:
journal article
Today's challenges in pharmacovigilance: what can we learn from epoetins?
Published in:
2011
By:
- Ebbers HC;
- Mantel-Teeuwisse AK;
- Moors EH;
- Schellekens H;
- Leufkens HG;
- Ebbers, Hans C;
- Mantel-Teeuwisse, Aukje K;
- Moors, Ellen H M;
- Schellekens, Huub;
- Leufkens, Hubert G
Publication type:
journal article
Mapping the safety profile of biologicals: a disproportionality analysis using the WHO adverse drug reaction database, VigiBase.
Published in:
2010
By:
- Giezen TJ;
- Mantel-Teeuwisse AK;
- Meyboom RH;
- Straus SM;
- Leufkens HG;
- Egberts TC;
- Giezen, Thijs J;
- Mantel-Teeuwisse, Aukje K;
- Meyboom, Ronald H B;
- Straus, Sabine M J M;
- Leufkens, Hubert G M;
- Egberts, Toine C G
Publication type:
journal article
Safety-related regulatory actions for orphan drugs in the US and EU: a cohort study.
Published in:
2010
By:
- Heemstra HE;
- Giezen TJ;
- Mantel-Teeuwisse AK;
- de Vrueh RL;
- Leufkens HG;
- Heemstra, Harald E;
- Giezen, Thijs J;
- Mantel-Teeuwisse, Aukje K;
- de Vrueh, Remco L A;
- Leufkens, Hubert G M
Publication type:
journal article
Evaluation of post-authorization safety studies in the first cohort of EU Risk Management Plans at time of regulatory approval.
Published in:
2009
By:
- Giezen TJ;
- Mantel-Teeuwisse AK;
- Straus SM;
- Egberts TC;
- Blackburn S;
- Persson I;
- Leufkens HG;
- Giezen, Thijs J;
- Mantel-Teeuwisse, Aukje K;
- Straus, Sabine M J M;
- Egberts, Toine C G;
- Blackburn, Stella;
- Persson, Ingemar;
- Leufkens, Hubert G M
Publication type:
journal article
Pharmacovigilance of biopharmaceuticals: challenges remain.
Published in:
2009
By:
- Giezen TJ;
- Mantel-Teeuwisse AK;
- Leufkens HG;
- Giezen, Thijs J;
- Mantel-Teeuwisse, Aukje K;
- Leufkens, Hubert G M
Publication type:
journal article
Drug-related nephrotoxic and ototoxic reactions : a link through a predictive mechanistic commonality.
Published in:
2008
By:
- Verdel BM;
- van Puijenbroek EP;
- Souverein PC;
- Leufkens HG;
- Egberts AC;
- Verdel, Bertha Maria;
- van Puijenbroek, Eugène P;
- Souverein, Patrick C;
- Leufkens, Hubert G M;
- Egberts, Antoine C G
Publication type:
journal article
Determinants of headache in lansoprazole users in The Netherlands: results from a nested case-control study.
Published in:
2002
By:
- Claessens, A.A.M.C.;
- Heerdink, E.R.;
- van Eijk, J.T.H.M.;
- Lamers, C.B.H.W.;
- Leufkens, H.G.M.;
- Claessens, Angela A M C;
- Heerdink, Eibert R;
- van Eijk, Jacques T H M;
- Lamers, Cornelis B H W;
- Leufkens, Hubert G M
Publication type:
journal article
Differences Between Post-Authorization Adverse Drug Reactions of Biopharmaceuticals and Small Molecules.
Published in:
BioDrugs, 2013, v. 27, n. 2, p. 167, doi. 10.1007/s40259-013-0012-y
By:
- Ebbers, Hans C.;
- Al-Temimi, Esraa;
- Moors, Ellen H. M.;
- Mantel-Teeuwisse, Aukje K.;
- Schellekens, Huub;
- Leufkens, Hubert G. M.
Publication type:
Article
Associations between uncertainties identified by the European Medicines Agency and national decision making on reimbursement by HTA agencies.
Published in:
CTS: Clinical & Translational Science, 2021, v. 14, n. 4, p. 1566, doi. 10.1111/cts.13027
By:
- Bloem, Lourens T.;
- Vreman, Rick A.;
- Peeters, Niels W. L.;
- Hoekman, Jarno;
- Elst, Menno E.;
- Leufkens, Hubert G. M.;
- Klungel, Olaf H.;
- Goettsch, Wim G.;
- Mantel‐Teeuwisse, Aukje K.
Publication type:
Article
Psychiatric and Cardiovascular Comorbidities in Patients With Diabetes Mellitus Starting Antiobesity Drugs.
Published in:
Obesity (19307381), 2008, v. 16, n. 10, p. 2331, doi. 10.1038/oby.2008.362
By:
- Willemen, Marjolein J.;
- Mantel-Teeuwisse, Aukje K.;
- Straus, Sabine M.;
- Leufkens, Hubert G.;
- Egberts, Antoine C.
Publication type:
Article
Relationship between Age and the Ability to Break Scored Tablets.
Published in:
Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00222
By:
- Notenboom, Kim;
- Vromans, Herman;
- Schipper, Maarten;
- Leufkens, Hubert G. M.;
- Bouvy, Marcel L.
Publication type:
Article
Change in parental knowledge, attitudes and practice of antibiotic use after a national intervention programme.
Published in:
European Journal of Public Health, 2018, v. 28, n. 4, p. 724, doi. 10.1093/eurpub/ckx240
By:
- Ivanovska, Verica;
- Angelovska, Bistra;
- Dijk, Liset van;
- Zdravkovska, Milka;
- Leufkens, Hubert G;
- Mantel-Teeuwisse, Aukje K
Publication type:
Article
Rituximab-induced thrombocytopenia: a cohort study.
Published in:
European Journal of Haematology, 2012, v. 89, n. 3, p. 256, doi. 10.1111/j.1600-0609.2012.01808.x
By:
- Giezen, Thijs J.;
- Mantel-Teeuwisse, Aukje K.;
- ten Berg, Maarten J.;
- Straus, Sabine M. J. M.;
- Leufkens, Hubert G. M.;
- Solinge, Wouter W.;
- Egberts, Toine C. G.
Publication type:
Article
Prescription Medications Associated with a Decreased Risk of Non-Hodgkin’s Lymphoma.
Published in:
American Journal of Epidemiology, 2003, v. 157, n. 6, p. 510, doi. 10.1093/aje/kwg004
By:
- Beiderbeck, Annette B.;
- Holly, Elizabeth A.;
- Sturkenboom, Miriam C. J. M.;
- Coebergh, Jan W. W.;
- Stricker, Bruno H. Ch.;
- Leufkens, Hubert G. M.
Publication type:
Article
Trends in access to anti‐malarial treatment in the formal private sector in Uganda: an assessment of availability and affordability of first‐line anti‐malarials and diagnostics between 2007 and 2018.
Published in:
Malaria Journal, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12936-021-03680-8
By:
- Kibira, Denis;
- Ssebagereka, Anthony;
- van den Ham, Hendrika A.;
- Opigo, Jimmy;
- Katamba, Henry;
- Seru, Morries;
- Reed, Tim;
- Leufkens, Hubert G.;
- Mantel-Teeuwisse, Aukje K.
Publication type:
Article
Impact of medicine shortages on patients - a framework and application in the Netherlands.
Published in:
2022
By:
- Postma, Doerine J.;
- De Smet, Peter A. G. M.;
- Notenboom, Kim;
- Leufkens, Hubert G. M.;
- Mantel-Teeuwisse, Aukje K.
Publication type:
journal article
Impact of medicine shortages on patients - a framework and application in the Netherlands.
Published in:
BMC Health Services Research, 2022, v. 22, n. 1, p. 1, doi. 10.1186/s12913-022-08765-x
By:
- Postma, Doerine J.;
- De Smet, Peter A. G. M.;
- Notenboom, Kim;
- Leufkens, Hubert G. M.;
- Mantel-Teeuwisse, Aukje K.
Publication type:
Article
In reply to: Knowledge of developmental pharmacology and modeling approaches should be used to avoid useless trials in children.
Published in:
2009
By:
- Tafuri, Giovanni;
- Trotta, Francesco;
- Leufkens, Hubert G. M.;
- Martini, Nello;
- Sagliocca, Luciano;
- Traversa, Giuseppe
Publication type:
Letter
Predictors of orphan drug approval in the European Union.
Published in:
European Journal of Clinical Pharmacology, 2008, v. 64, n. 5, p. 545, doi. 10.1007/s00228-007-0454-6
By:
- Heemstra, Harald E.;
- de Vrueh, Remco L.;
- van Weely, Sonja;
- Büller, Hans A.;
- Leufkens, Hubert G. M.
Publication type:
Article
Prior outpatient antibiotic use as predictor for microbial aetiology of community-acquired pneumonia: hospital-based study.
Published in:
European Journal of Clinical Pharmacology, 2008, v. 64, n. 4, p. 405, doi. 10.1007/s00228-007-0407-0
By:
- van de Garde, Ewoudt M. W.;
- Endeman, Henrik;
- van Hemert, Remco N.;
- Voorn, G Paul;
- Deneer, Vera H. M/;
- Leufkens, Hubert G. M.;
- van den Bosch, Jules M. M.;
- Biesma, Douwe H.
Publication type:
Article
Incidence and determinants of long-term use of antidepressants.
Published in:
European Journal of Clinical Pharmacology, 2004, v. 60, n. 1, p. 57, doi. 10.1007/s00228-004-0726-3
By:
- Meijer, Welmoed E. E.;
- Heerdink, E. R.;
- Leufkens, Hubert G. M.;
- Herings, Ron M. C.;
- Egberts, Antoine C. G.;
- Nolen, Willem A.
Publication type:
Article
Short-acting parenteral antipsychotics drive choice for classical versus atypical agents.
Published in:
European Journal of Clinical Pharmacology, 2003, v. 58, n. 11, p. 757, doi. 10.1007/s00228-002-0545-3
By:
- Hugenholtz, Gerard W. K.;
- Stolker, Joost J.;
- Heerdink, Eibert R.;
- Nolen, Willem A.;
- Leufkens, Hubert G. M.
Publication type:
Article
Initial 3-month usage characteristics predict long-term use of benzodiazepines: an 8-year follow-up.
Published in:
European Journal of Clinical Pharmacology, 2003, v. 58, n. 10, p. 689, doi. 10.1007/s00228-002-0548-0
By:
- van Hulten, Rolf;
- Teeuw, K. Bart;
- Bakker, Albert;
- Leufkens, Hubert G.
Publication type:
Article
The Role of Regulator-Imposed Post-Approval Studies in Health Technology Assessments for Conditionally Approved Drugs.
Published in:
International Journal of Health Policy & Management, 2022, v. 11, n. 5, p. 642, doi. 10.34172/ijhpm.2020.198
By:
- Vreman, Rick A.;
- Bloem, Lourens T.;
- van Oirschot, Stijn;
- Hoekman, Jarno;
- van der Elst, Menno E.;
- Leufkens, Hubert G. M.;
- Klungel, Olaf H.;
- Goettsch, Wim G.;
- Mantel-Teeuwisse, Aukje K.
Publication type:
Article
Regulatory, health technology assessment and company interactions: the current landscape and future ecosystem for drug development, review and reimbursement.
Published in:
International Journal of Technology Assessment in Health Care, 2023, v. 39, n. 1, p. 1, doi. 10.1017/S0266462323000144
By:
- Ting Wang;
- McAuslane, Neil;
- Goettsch, Wim G.;
- Leufkens, Hubert G. M.;
- De Bruin, Marie L.
Publication type:
Article
Addressing uncertainty in relative effectiveness assessments by HTA organizations.
Published in:
International Journal of Technology Assessment in Health Care, 2022, v. 38, n. 1, p. 1, doi. 10.1017/S026646232100177X
By:
- Vreman, Rick A.;
- Strigkos, George;
- Leufkens, Hubert G. M.;
- Schünemann, Holger J.;
- Mantel-Teeuwisse, Aukje K.;
- Goettsch, Wim G.
Publication type:
Article
Addressing uncertainty in relative effectiveness assessments by HTA organizations.
Published in:
International Journal of Technology Assessment in Health Care, 2021, v. 38, n. 1, p. 1, doi. 10.1017/S026646232100177X
By:
- Vreman, Rick A.;
- Strigkos, George;
- Leufkens, Hubert G. M.;
- Schünemann, Holger J.;
- Mantel-Teeuwisse, Aukje K.;
- Goettsch, Wim G.
Publication type:
Article
Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom.
Published in:
2015
By:
- Yska, Jan Peter;
- van Roon, Eric N.;
- de Boer, Anthonius;
- Leufkens, Hubert G. M.;
- Wilffert, Bob;
- de Heide, Loek J. M.;
- de Vries, Frank;
- Lalmohamed, Arief
Publication type:
journal article
Precision medicine in diabetes and diabetic kidney disease: Regulatory considerations.
Published in:
Diabetes, Obesity & Metabolism, 2018, v. 20, p. 19, doi. 10.1111/dom.13453
By:
- Mol, Peter G. M.;
- Thompson, Aliza;
- Heerspink, Hiddo J. L.;
- Leufkens, Hubert G. M.
Publication type:
Article

Found: 155