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In vitro metabolic characterization of orbitazine, a novel derivative of the PAC-1 anticancer agent.
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- Journal of Pharmacy & Pharmacology, 2021, v. 73, n. 11, p. 1199, doi. 10.1111/jphp.13296
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- Article
In vitro metabolic characterization of orbitazine, a novel derivative of the PAC‐1 anticancer agent.
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- Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 9, p. 1199, doi. 10.1111/jphp.13296
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- Article
Protective effects of mefunidone on ischemia-reperfusion injury/Folic acid-induced acute kidney injury.
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- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1043945
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- Article
Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 304, doi. 10.3390/ph16020304
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- Article
A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 244, doi. 10.3390/ph16020244
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- Article
Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as NADPH Oxidase (NOX) Inhibitors.
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- Chemical Biology & Drug Design, 2024, v. 104, n. 2, p. 1, doi. 10.1111/cbdd.14610
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- Article
Imidazo[1,2‐a]pyridine Derivatives as AMPK Activators: Synthesis, Structure–Activity Relationships, and Regulation of Reactive Oxygen Species in Renal Fibroblasts.
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- ChemMedChem, 2023, v. 18, n. 8, p. 1, doi. 10.1002/cmdc.202200696
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- Article
9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non‐small‐cell lung cancer.
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- Journal of Cellular Physiology, 2019, v. 234, n. 11, p. 20728, doi. 10.1002/jcp.28679
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- Article
Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway.
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- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.772031
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- Article
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
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- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.713572
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- Article
Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction.
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- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129283
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- Article
Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways.
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- PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0111242
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- Article
Novel pyrazolo[3,4‐b]pyridine derivatives: Synthesis, structure–activity relationship studies, and regulation of the AMPK/70S6K pathway.
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- Archiv der Pharmazie, 2022, v. 355, n. 7, p. 1, doi. 10.1002/ardp.202100465
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- Article
Design, synthesis, and biological evaluation of 1,2,4‐oxadiazole‐containing pyrazolo[3,4‐b]pyridinones as a new series of AMPKɑ1β1γ1 activators.
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- Archiv der Pharmazie, 2021, v. 354, n. 7, p. 1, doi. 10.1002/ardp.202000458
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- Article
Synthesis and structure–activity relationships of pyrazolo‐[3,4‐b]pyridine derivatives as adenosine 5'‐monophosphate‐activated protein kinase activators.
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- Archiv der Pharmazie, 2019, v. 352, n. 8, p. N.PAG, doi. 10.1002/ardp.201900066
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- Article
Synthesis, Pharmacophores, and Mechanism Study of Pyridin-2(1 H)-one Derivatives as Regulators of Translation Initiation Factor 3A.
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- Archiv der Pharmazie, 2013, v. 346, n. 9, p. 654, doi. 10.1002/ardp.201300138
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Synthesis, Pharmacokinetics, and Pharmacodynamics Studies of Valsartan Peptide Derivatives.
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- Archiv der Pharmazie, 2012, v. 345, n. 5, p. 393, doi. 10.1002/ardp.201100377
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- Article
Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/ IL-1R1/MyD88/ NF-κB pathway.
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- Journal of Cellular & Molecular Medicine, 2016, v. 20, n. 11, p. 2064, doi. 10.1111/jcmm.12898
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- Article
Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice.
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- FASEB Journal, 2021, v. 35, n. 1, p. 1, doi. 10.1096/fj.202001138RR
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- Article
Fluorofenidone protects against acute kidney injury.
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- FASEB Journal, 2019, v. 33, n. 12, p. 14325, doi. 10.1096/fj.201901468RR
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- Article
Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways.
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- Experimental & Therapeutic Medicine, 2019, v. 18, n. 1, p. 41, doi. 10.3892/etm.2019.7548
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- Article
Fluorofenidone attenuates interleukin‐1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction.
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- Nephrology, 2018, v. 23, n. 6, p. 573, doi. 10.1111/nep.13062
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- Article
The Protective Effect of Fluorofenidone against Cyclosporine A-Induced Nephrotoxicity.
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- Kidney & Blood Pressure Research, 2019, v. 44, n. 4, p. 656, doi. 10.1159/000500924
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- Article
Cost-effectiveness Analysis of Pembrolizumab Plus Axitinib Versus Sunitinib in First-line Advanced Renal Cell Carcinoma in China.
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- Clinical Drug Investigation, 2019, v. 39, n. 10, p. 931, doi. 10.1007/s40261-019-00820-6
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- Article
The antihepatic fibrotic effects of fluorofenidone via MAPK signalling pathways.
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- European Journal of Clinical Investigation, 2013, v. 43, n. 4, p. 358, doi. 10.1111/eci.12053
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- Article
Fluorofenidone Attenuates Tubulointerstitial Fibrosis by Inhibiting TGF-β<sub>1</sub>-Induced Fibroblast Activation.
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- American Journal of Nephrology, 2011, v. 34, n. 2, p. 181, doi. 10.1159/000329080
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- Article
Design, Synthesis and Anti-fibrosis Activity Study of N<sub>1</sub>-Substituted Phenylhydroquinolinone Derivatives.
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- Molecules, 2012, v. 17, n. 2, p. 1373, doi. 10.3390/molecules17021373
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- Article
Design, Synthesis and Antifibrotic Activities of Carbohydrate- Modified 1-(Substituted aryl)-5-trifluoromethyl-2(1H) Pyridones.
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- Molecules, 2012, v. 17, n. 1, p. 884, doi. 10.3390/molecules17010884
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- Article
A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1414066
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- Article