Title: The role of MEK inhibition in pediatric low-grade gliomas.
Authors: Sheikh, Shehryar R.; Klesse, Laura J.; Mangum, Ross; Bui, Ashley; Siegel, Benjamin I.; Abdelbaki, Mohamed S.; Patel, Neha J.
Abstract: Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in children. Many patients with unresectable tumors experience recurrence or long-term sequelae from standard chemotherapeutics. This mini-review explores the emerging role of MEK inhibitors in the management of pLGGs, highlighting their potential to transform current treatment paradigms. We review the molecular basis for therapeutic MEK inhibition in the context of pLGG, provide an evidence base for the use of the major MEK inhibitors currently available in the market for pLGG, and review the challenges in the use of MEKi inhibitors in this population.
Subjects: TUMORS in children; BRAIN tumors; GLIOMAS; DISEASE relapse; MITOGEN-activated protein kinases
Publication: Frontiers in Oncology, 2025, p1
ISSN: 2234-943X
Publication type: Academic Journal
DOI: 10.3389/fonc.2024.1503894

The role of MEK inhibition in pediatric low-grade gliomas.

Sheikh, Shehryar R.; Klesse, Laura J.; Mangum, Ross; Bui, Ashley; Siegel, Benjamin I.; Abdelbaki, Mohamed S.; Patel, Neha J.